Newly published research from the University of Houston College of Pharmacy identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise. It’s a finding that opens the door to the development of targeted therapies for various muscle disorders, like Muscular Dystrophy, which affect millions of people worldwide.
When it comes to muscles and muscle disorders, the importance of a discovery like this cannot be overstated.
The muscle of muscles
The very core function of life — breathing — is controlled by your skeletal muscles, as is regulation of whole-body metabolism and every movement you make:
And even blinking
In context
Skeletal muscles are formed during embryonic development by the fusion of hundreds of specialized cells called myoblasts. Adult skeletal muscles maintain regenerative capacity, which is attributed to the presence of muscle stem cells, named satellite cells.
After injury, satellite cells undergo several rounds of proliferation followed by their differentiation into myoblasts. These myoblasts once again fuse with each other and to injured myofibers to accomplish muscle regeneration.
In many muscular disorders, this intrinsic capacity of muscles to regenerate is diminished resulting in the loss of muscle mass and function.
The science
UH researchers found that Inositol-requiring enzyme 1, a key signaling protein, is essential for myoblast fusion during muscle formation and growth.
“During muscle regeneration, IRE1 augments the activity of X-box binding protein 1 which in turn stimulates the gene expression of multiple transmembrane proteins required for myoblast fusion,” reports Ashok Kumar, Else and Philip Hargrove Endowed Professor of pharmacy in the Department of Pharmacological and Pharmaceutical Sciences at the UH College of Pharmacy, in EMBO Reports.
According to researchers, increasing the levels of IRE1 or XBP1 in muscle stem cells outside the body, followed by their injection in patients’ muscle tissues will improve muscle repair and reduce the severity of disease.
“We also found that augmenting the levels of IRE1α or XBP1 in myoblasts leads to the formation of myotubes (muscle cells) having an increased diameter,” said Kumar.
That increase in diameter can be significant.
“Size is very important for muscle. Muscle grows only in size, not in number,” said Aniket Joshi, a graduate student in Kumar’s lab and first author on the article. “Muscular people have larger muscle cells. Larger muscles generally work better- can lift more weight, run and walk faster, and improve overall metabolism of the body and prevent various diseases, such as type II diabetes.”
Flexing their muscles
This new research is not the first flex for Kumar’s team. In 2021, research from Kumar’s lab published in the ELife journal described the role of the IRE1α/XBP1 signaling axis in regeneration of healthy skeletal muscle after acute injury and in models of Duchenne Muscular Dystrophy. In this study, they found that IRE1α/XBP1 signaling axis also plays an important cell autonomous role in satellite cells.
Along with Kumar and Joshi, post-doctoral fellow Meiricris Tomaz da Silva and research assistant professor, Anirban Roy conducted the research in Kumar’s lab. Other authors on the article from the University of Houston include Micah Castillo, Preethi Gunaratne, Mingfu Wu, Yu Liu, and a former post-doctoral fellow in Kumar’s lab Tatiana E. Koike along with Takao Iwawaki of Kanazawa Medical University, Japan.
While promoting the single, Jade has said her song is intended to represent the highs and lows she’s experienced during her 13 years in the public eye.
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One lyric in particular, “sold my soul to a psycho”, has been interpreted by many as a jab at Simon Cowell, whose now-defunct record label, Syco, she and her bandmates were signed to for almost a decade after winning The X Factor in 2011.
Responding to the lyric, a representative for Simon Cowell’s entertainment company told the Daily Mail: “The entire team who worked incredibly hard behind the scenes with Little Mix to help make the group a success would, I’m sure, always continue to wish them solo success.”
Little Mix performing in front of Simon Cowell on The X Factor in 2017
Summers/Thames/Syco/Shutterstock
Jade previously said: “[Angel Of My Dreams] is about how obsessed I am with the industry – so there are lyrics like ‘love when you call me a star’ – but also there’s the dark side that comes with that. It’s not as glam as it seems.”
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The track opens with a sample of Sandie Shaw’s Eurovision-winning Puppet On A String, of which Jade said: “In the beginning of our career you do think you are this puppet, but at the same time it isn’t true – we wrote a lot of our songs, and we were behind a lot of what we put out there. I resented that as a statement.
“So, it felt natural to take that and show that it can be true and untrue at the same time.”
Jade Thirlwall launched her solo career last week with her debut single Angel Of My Dreams
The Official Charts Company announced on Sunday that Angel Of My Dreams is currently on track to chart at number two in this weeks UK singles chart.
The home secretary has claimed the Tories intended on spending £10 billion on the now-scrapped Rwanda deportation scheme.
In the Commons on Monday, Yvette Cooper said the full expense of the plan to send asylum seekers who arrive to the UK in small boats to Rwanda was not fully disclosed to parliament.
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The policy, which Labour dropped when it got into power earlier this month, has already cost the British taxpayer £700m over the last two and a half years, according to Cooper.
Cooper continued: “Those costs include £290m payments to Rwanda, chartering flights that never took off, detaining hundreds of people and then releasing them, and paying for more 1,000 civil servants to work on the scheme.
Cooper also said if the scheme had ever “got going” it would only cover a “minority” of arrivals and the taxpayer would still have to pay out “no matter how many people were relocated”.
The cabinet minister added: “Over the six years of the migration and economic development partnership forecast, the previous government had planned to spend over £10bn of taxpayers money on the scheme – they did not tell parliament that.”
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Cooper dubbed it a “costly con” which has been paid for by the taxpayer.
Keir Starmer: \"Let me be clear, there is no need to withdraw from the European Convention on Human Rights… not now, not ever… Britain belongs on the world stage.\" pic.twitter.com/58lWXA6Pmr
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Keir Starmer: “Let me be clear, there is no need to withdraw from the European Convention on Human Rights… not now, not ever… Britain belongs on the world stage.” pic.twitter.com/58lWXA6Pmr
One of the writers behind Sandie Shaw’s Puppet On A String has given the thumbs up to former Little Mix star Jade Thirlwall’s use of the song on her debut solo single.
Phil Coulter co-wrote the hit with Bill Martin, eventually scoring the UK its first of five wins at the Eurovision Song Contest back in 1967.
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Last week, Jade debuted her new song Angel Of My Dreams, which opens with a distorted version of Puppet On A String, which is then sampled throughout the song.
Reacting to the news, Phil told BBC News NI he was “thrilled” at his song’s inclusion on Jade’s single.
Sandie Shaw performing Puppet On A String in 1967
ullstein bild Dtl. via ullstein bild via Getty Images
“I would love to tell you that I’m on speed dial with Little Mix and all of those hot producers, but in fact I was completely unaware until one of my kids and grandkids told me,” he joked, revealing his family assured him Jade’s song was getting “[good] reviews left, right and centre” and is “going to be the song of the summer”.
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Phil continued: “I made a point of listening to the song. I am delighted and very flattered and flabbergasted and surprised that I am part of this whole operation.”
“It’s very unusual. I have six kids – it didn’t happen too often that they would bask in the glory of their dad having music in the charts, in fact they would have been embarrassed, they would have preferred if I was an accountant,” he admitted.
“At this stage, if this does become the big hit of the summer, I am in grave danger of becoming cool. Secretly they might have been pleased but they didn’t express that too often, so I suppose now at this advanced stage for me to be seen to be trendy and cool, is something that I embrace.”
Puppet On A String was previously sampled by Lily Allen on her hit Alfie.
Puppet On A String co-writers Bill Martin and Phil Coulter
Bob Baker/Redferns
Jade revealed to Audacy last week: “Originally, the chorus [of Angel Of My Dreams] was me singing [Puppet On A String]. And then we re-wrote a chorus to go on top of it.
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“It probably did sound quite different initially, but the kind of chaos of it was always there. We knew that’s what we wanted to do… I wanted it to feel like there was a lot going on.”
She previously claimed she’d been trying to sample Puppet On A String on a track “for years”, and revealed: “In the beginning of our career you do think you are this puppet, but at the same time it isn’t true – we wrote a lot of our songs, and we were behind a lot of what we put out there I resented that as a statement.
“So it felt natural to take that and show that it can be true and untrue at the same time.”
The Official Charts Company revealed on Sunday that Angel Of My Dreams is currently on track to chart at number two in this weeks UK singles chart.
Check out the song for yourself in the video below:
Conservative mayor Lord Houchen called for “civility” in the upcoming Tory leadership contest, shortly after Suella Braverman’s made some eyebrow-raising comments about the party’s direction.
The former home secretary and current backbencher – who is expected to run as Conservative leader – criticised people who lean further to centre over the weekend.
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She told The Telegraph: “If we don’t recover the votes we deliberately, and arrogantly, spurned, we will turn the Conservative Party into the 21st Century version of the 20th Century Liberal Party.
“We can do better than being a collection of fanatical, irrelevant, centrist cranks, who make it our business to insult our should-be voters for not being as smug and self-righteous as we are.”
Asked what he made of these comments on Sky News on Sunday, Houchen said the Tory party leadership should not be based on the past, but the future.
He also there should not be any “blue-on-blue attacks”.
Houchen added: “If we want to spend the next two, three, four, five months fighting with each other that goes to the cause of the election defeat just two weeks ago.
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“And I would implore Suella, as well as every other leadership contender, to conduct this leadership contest with civility. Let’s come together and let’s offer a positive option to the country.”
He said voters “want a party that isn’t going to fight like cats in a sack”, adding that the electorate thought the Tories cared more about “in-fighting and positioning within the Conservative Party and within the government than caring about our country”.
The mayor suggested any future Tory leader needs to rule out working with Reform too, as they are a “symptom not a cause” of the problem.
But Braverman called for a deal with the populist party only a few weeks ago.
Speaking to GB Newsearlier this month, she said there was “only room for one Conservative Party on the right of British politics”.
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The backbencher said: “There’s very little I disagree with when it comes to Nigel Farage and I met thousands of people throughout this campaign, and many, many people said to me, I’m a lifelong Tory voter, but I’m going to vote Reform.”
“They are feeling betrayed. They feel let down. They feel politically homeless because of our failures,” she added.
“So we have to address the issue of Reform. I’m not really interested in the form of what that takes, but we need to find an accommodation with Reform, with Nigel Farage, so that we can take the fight to Labour and win the next election.”
Before the exchequer’s secretary James Murray was elected to parliament, he was the deputy mayor of London under Sadiq Khan.
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He held this role from 2016 to 2019 – meaning he was in office when his boss Khan allowed a six-metre high cartoon baby blimp of the then-US president to float across the capital.
It was part of a wider protest against the divisive politician’s first formal visit to the UK in 2018.
Phillips recalled the famous blimp on his programme this morning, asking Murray: “Do you now wish you hadn’t chosen to insult him in this way?”
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The minister replied: “Look there’s been a lot of history between the mayor and President Trump but what’s important for me is being a minister in the government is that we have a relationship with the US, which is an incredibly strong one, and one that’s in our national interests and good for our national security.”
Phillips hit back: “It’s quite tricky to have a good relationship with somebody when one of your colleague has described him as a neo-Nazi and your former boss called him literally a few weeks, a racist, a sexist and a homophobe.”
“Is that the way diplomacy these days under Labour?” Phillip asked.
Murray said: “In the past there have been comments on all sides of this relationship, but what it’s important for me is the strength of a relationship –”
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Phillips cut him off, saying: “The strength of a relationship with someone who called you a neo-Nazi is not going to be very strong, is it?”
He said the UK-US “transcends any individuals”, and “it’s in our interests in terms of national security and economy” to get along well.
Phillips pushed: “You understand why this is an issue, don’t you?”
He noted that Lammy is now calling Trump’s running mate JD Vance is his friend and that chancellor Rachel Reeves is talking about a trade deal with the US.
He said: “You’re all going to have change your tune aren’t you?”
Murray said Labour have “never” changed their tune in their approach to the US, and that it is up to American voters to choose their president.
A top Tory has been called out for interrupting a cabinet minister and heckling jim from the dispatch box.
Shadow health secretary Victoria Atkins, who is expected to run for the party leadership, had to be rebuked by the deputy speaker for her “abominable” behaviour in the Commons.
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On Friday afternoon, the new environment, food and rural affairs secretary Steve Reed began his first speech as a member of government by talking about the Labour’s plan to “get Britain building again”.
It was part of the parliamentary debate on the King’s Speech.
But, he was interrupted repeatedly by Tories – first by Tory backbencher and former party chair Richard Holden, who stood up to indicate he wanted to speak.
But Reed refused to give way, saying there was not enough time for Holden’s speech and that other “members should have spoken for less time” earlier in the three-hour debate.
Reed then attacked the Conservatives for neglected parts of the country.
The shadow housing, communities and local government secretary, Kemi Badenoch, who is also expected to try out for Tory leader, then attempted to cut in.
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But Reed said: “I am very sorry but there are only three minutes left and I need to cover the points that have been raised. They had their time.”
He resumed by talking about how Labour plans to increase the number of mental health professionals.
Atkins then jumped up and leant across the despatch box while shouting at Reed, seemingly irate.
The deputy speaker Sir Christopher Chope had to shout: “Order. The right honourable member for Louth and Horncastle [Atkins] has behaved abominably.”
According to The Guardian, a spokesperson for Atkins’ office said: “Conservative MPs were trying to get answers about their budgets for farming, flood defences and food security, which the minister ignored.
“She will always stand up fearlessly for farmers and our rural area in Westminster, even if that means a rare admonishment from the Chair.”
Reed wrapped up his speech by reeling off the “Tories’ failure”, calling his opponents “the party of broken dreams”.
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Closing the debate, Reed said: “After 14 years of chaos, there is once again hope for our environment, hope for our countryside and hope for our rural communities. I welcome the king’s speech, I recommend it to this house.”
Over the weekend, clips of this exchange were picked up by other MPs….
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