“Extreme temperature events are becoming more frequent, longer and more intense, and their adverse health effects have drawn growing concern. Another environmental issue worldwide is the presence of fine particulate matter in the air, which may interact synergistically with extreme temperatures to adversely affect cardiovascular health,” said senior author Yuewei Liu, M.D., Ph.D., an associate professor of epidemiology in the School of Public Health at Sun Yat-sen University in Guangzhou, China. “However, it remains unknown if and how co-exposure to extreme temperatures and fine particulate pollution might interact to trigger a greater risk of death from heart attack, which is an acute response potentially brought on by an acute scenario and a great public health challenge due to its substantial disease burden worldwide.”

To examine the impact of extreme temperatures with and without high levels of fine particulate pollution, the researchers analyzed 202,678 heart attack deaths between 2015-2020 that occurred in Jiangsu province, a region with four distinct seasons and a wide range of temperatures and fine particulate pollution levels. The deaths were among older adults with an average age of 77.6 years; 52% were older than age 80; and 52% were male. Particulate exposure on the day of each death and one day before death were included in the analysis.

Extreme temperatures were gauged according to the daily heat index (also referred to as apparent temperature) for an area, which captures the combined effect of both heat and humidity. Both the length and extremeness of heat waves and cold snaps were evaluated. Heart attack deaths, or case days, during these periods were compared with control days on the same day of the week in the same month — meaning that if a death occurred on a Wednesday, all other Wednesdays in the same month would be considered control days. Particulate levels were considered high on any day with an average level of fine particulate matter above 37.5 micrograms per cubic meter.

“Our findings provide evidence that reducing exposure to both extreme temperatures and fine particulate pollution may be useful to prevent premature deaths from heart attack, especially for women and older adults,” Liu said.

Compared with control days, the risk of a fatal heart attack was observed at the following levels:

• 18% higher during 2-day heat waves with heat indexes at or above the 90^th percentile (ranging from 82.6 to 97.9 degrees Fahrenheit), increasing with temperature and duration, and was 74% higher during 4-day heat waves with heat indexes at or above the 97.5^th percentile (ranging from 94.8 to 109.4 degrees Fahrenheit). For context, 6,417 (3.2%) of the 202,678 observed deaths from heart attack happened during heat waves with heat indexes at or above the 95^th percentile (ranging from 91.2 to 104.7 degrees Fahrenheit) for three or more days.
• 4% higher during 2-day cold snaps with temperatures at or below the 10^th percentile (ranging from 33.3 to 40.5 degrees Fahrenheit), increasing with lower temperatures and duration, and was 12% higher during 3-day cold snaps with temperatures at or below the 2.5^th percentile (ranging from 27.0 to 37.2 degrees Fahrenheit). For context, 6,331 (3.1%) of the 202,678 observed deaths from heart attack happened during cold spells with temperatures at or below the 5^th percentile (ranging from 30.0 to 38.5 degrees Fahrenheit) for 3 or more days.
• Twice as high during 4-day heat waves that had fine particulate pollution above 37.5 micrograms per cubic meter. Days with high levels of fine particulate pollution during cold snaps did not have an equivalent increase in the risk of heart attack death.
• Generally higher among women than men during heat waves.
• Higher among people ages 80 and older than in younger adults during heat waves, cold snaps or days with high levels of fine particulate pollution.
• The mean age of all individuals who died from a heart attack in Jiangsu from 2015-2020, including during non-extreme temperature events, was 77.6 years old; 52.1% of these individuals were over 80 years old.

The researchers estimated that up to 2.8% of heart attack deaths may be attributed to the combination of extreme temperatures and high levels of fine particulate pollution (> 37.5 micrograms per cubic meter), according to WHO targets.

“Strategies for individuals to avoid negative health effects from extreme temperatures include following weather forecasts, staying inside when temperatures are extreme, using fans and air conditioners during hot weather, dressing appropriately for the weather, proper hydration and installing window blinds to reduce indoor temperatures,” said Liu. “Using an air purifier in the house, wearing a mask outdoors, staying clear of busy highways when walking and choosing less-strenuous outdoor activities may also help to reduce exposure to air pollution on days with high levels of fine particulate pollution. To improve public health, it is important to take fine particulate pollution into consideration when providing extreme temperature warnings to the public.”

In a 2020 scientific statement and a 2020 policy statement, the American Heart Association details the latest science about air pollution exposure and the individual, industrial and policy measures to reduce the negative impact of poor air quality on cardiovascular health. Reducing exposure to air pollution and reversing the negative impact of poor air quality on cardiovascular health, including heart disease and stroke, is essential to reducing health inequities in Black and Hispanic communities, those that have been historically marginalized and under-resourced, and communities that have the highest levels of exposure to air pollution.

The investigators recommended additional research about the possible interactive effects of extreme weather events and fine particulate pollution on heart attack deaths in areas with different temperature and pollution ranges to confirm their findings. The study did not include adjustments for any adaptive behaviors taken by individuals, such as using air conditioning and staying indoors, when temperatures are extreme or pollution levels are high, which could cause misclassification of individuals’ exposure to weather and alter their risk patterns. These results also may not be generalizable to other regions in China or other countries due to potential variations of adaption capacity and temperature distribution.

Background:

• Fine particulates are less than 2.5 microns in size and may be inhaled deep into the lungs, where they can irritate the lungs and blood vessels around the heart. Most are associated with fuel combustion, such as particles from car exhaust, factory emissions or wildfires.
• Previous research has confirmed that exposure to particulate matter including fine particulates is linked to heart disease, stroke and other health issues.
• For context, the World Health Organization’s target for average annual exposure to fine particulate pollution level is no more than 5 micrograms per cubic meter and no more than 15 micrograms per cubic meter for more than 3-4 days per year.
• In this study, heat waves were defined as periods at or above the 90^th, 92.5^th, 95^th and 97.5^th percentiles of daily heat indexes (ranging from 82.6 to 109.4 degrees Fahrenheit across Jiangsu province, China) for at least 2, 3 or 4 consecutive days.
• Cold spells were defined as periods at or below the 10^th, 7.5^th, 5^th, 2.5^th percentiles of daily heat indexes (ranging from 27 to 40.5 degrees Fahrenheit) for at least 2, 3 or 4 consecutive days.

According to the law of conservation of energy, energy is never created or destroyed but only changes form from one to another depending on the interaction between the entities involved. All energy eventually ends up as heat. For us that can be a useful thing, for example, when we want to heat our homes in winter; or detrimental, when we want to cool something down, or get the most out of a battery-driven application. In any case, the better we can manage the thermal behavior of a device, the better we can engineer around this inevitable effect and improve the efficiency of the device in question. However, this is easier said than done, as knowing how heat flows inside some complex, miniature or hazardous device is something ranging from the difficult to the impossible, depending on the application.

Inspired by this problem, Project Associate Professor Tomoya Higo and Professor Satoru Nakatsuji from the Department of Physics at the University of Tokyo, and their team, which included a corporate partnership, set out to find a solution. “The amount of heat conducted through a material is known as its heat flux. Finding new ways to measure this could not only help improve device efficiency, but also safety, as batteries with poor thermal management can be unsafe, and even health, as various health or lifestyle issues can relate to body heat,” said Higo. “But finding a sensor technology to measure heat flux, while also satisfying a number of other conditions, such as robustness, cost efficiency, ease of manufacture and so on, is not easy. Typical thermal diode devices are relatively large and only give a value for temperature in a specific area, rather than an image, of the heat flux across an entire surface.”

The team explored the way a heat flux sensor consisting of certain special magnetic materials and electrodes behaves when there are complex patterns of heat flow. The magnetic material based on iron and gallium exhibits a phenomenon known as the anomalous Nernst effect (ANE), which is where heat energy is unusually converted to an electrical signal. This is not the only magnetic effect that can turn heat into power, though. There is also the Seebeck effect, which can actually create more electrical power, but it requires a large bulk of material, and the materials are brittle so hard to work with. ANE, on the other hand, allowed the team to engineer their device on an incredibly thin and malleable sheet of plastic.

“By finding the right magnetic and electrode materials and then applying them in a special repeating pattern, we created microscopic electronic circuits that are flexible, robust, cheap and easy to produce, and most of all are very good at outputting heat flux data in real time,” said Higo. “Our method involves rolling a thin sheet of clear, strong and lightweight PET plastic as a base layer, with magnetic and electrode materials sputtered onto it in thin and consistent layers. We then etch our desired patterns into the resultant film, similar to how electronic circuits are made.”

The team designed the circuits in a particular kind of way to boost ANE whilst also suppressing the Seebeck effect, as this actually interferes with the data-gathering potential of ANE. Previous attempts to do this were unsuccessful in any way that could be easily scaled up and potentially commercialized, making this sensor the first of its kind.

“I envisage seeing downstream applications such as power generation or data centers, where heat impedes efficiency. But as the world becomes more automated, we might see these kinds of sensors in automated manufacturing environments where they could improve our ability to predict machine failures, certain safety issues, and more,” said Nakatsuji. “With further developments, we might even see internal medical applications to help doctors produce internal heat maps of specific areas of the body, or organs, to aid in imaging and diagnosis.”

New measurements by NASA’s James Webb Space Telescope’s MIRI (Mid-Infrared Instrument) have detected water vapor in the system’s inner disk, at distances of less than 100 million miles (160 million kilometers) from the star — the region where rocky, terrestrial planets may be forming. (The Earth orbits 93 million miles from our Sun.) This is the first detection of water in the terrestrial region of a disk already known to host two or more protoplanets.

“We’ve seen water in other disks, but not so close in and in a system where planets are currently assembling. We couldn’t make this type of measurement before Webb,” said lead author Giulia Perotti of the Max Planck Institute for Astronomy (MPIA) in Heidelberg, Germany.

“This discovery is extremely exciting, as it probes the region where rocky planets similar to Earth typically form,” added MPIA director Thomas Henning, a co-author on the paper. Henning is co-principal investigator of Webb’s MIRI (Mid-Infrared Instrument), which made the detection, and the principal investigator of the MINDS (MIRI Mid-Infrared Disk Survey) program that took the data.

A Steamy Environment for Forming Planets

PDS 70 is a K-type star, cooler than our Sun, and is estimated to be 5.4 million years old. This is relatively old in terms of stars with planet-forming disks, which made the discovery of water vapor surprising.

Over time, the gas and dust content of planet-forming disks declines. Either the central star’s radiation and winds blow out such material, or the dust grows into larger objects that eventually form planets. As previous studies failed to detect water in the central regions of similarly aged disks, astronomers suspected it might not survive the harsh stellar radiation, leading to a dry environment for the formation of any rocky planets.

Astronomers haven’t yet detected any planets forming within the inner disk of PDS 70. However, they do see the raw materials for building rocky worlds in the form of silicates. The detection of water vapor implies that if rocky planets are forming there, they will have water available to them from the beginning.

“We find a relatively high amount of small dust grains. Combined with our detection of water vapor, the inner disk is a very exciting place,” said co-author Rens Waters of Radboud University in The Netherlands.

What is the Water’s Origin?

The discovery raises the question of where the water came from. The MINDS team considered two different scenarios to explain their finding.

One possibility is that water molecules are forming in place, where we detect them, as hydrogen and oxygen atoms combine. A second possibility is that ice-coated dust particles are being transported from the cool outer disk to the hot inner disk, where the water ice sublimates and turns into vapor. Such a transport system would be surprising, since the dust would have to cross the large gap carved out by the two giant planets.

Another question raised by the discovery is how water could survive so close to the star, when the star’s ultraviolet light should break apart any water molecules. Most likely, surrounding material such as dust and other water molecules serves as a protective shield. As a result, the water detected in the inner disk of PDS 70 could survive destruction.

Ultimately, the team will use two more of Webb’s instruments, NIRCam (Near-Infrared Camera) and NIRSpec (Near-Infrared Spectrograph) to study the PDS 70 system in an effort to glean an even greater understanding.

These observations were taken as part of Guaranteed Time Observation program 1282. This finding has been published in the journal Nature.