The Substance has undeniably become one of the most talked-about movies of the past year thanks to its grisly gore and violence, scenes of full nudity and career-best performances from leads Demi Moore and Margaret Qualley.
But there’s one other thing that plenty of viewers picked up when watching the graphic body horror.
Yes, we’re talking about all of those arses.
Coralie Fargeat’s film is littered with close-ups of bums, whether it’s Demi Moore’s Elisabeth Sparkle in the shower, Margaret Qualley clad in lycra for her energetic aerobics routine or just the man that Sue sleeps with the night before her big New Year’s Eve show standing in the buff in the hallway.
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(Also so many butts. Half the time it felt like the camera was stuck at butt level. I did not mind. But it was an interesting artistic choice: butts)
— R \"Nearest\" Nabors (they/them) (@rachelnabors) February 4, 2025
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","type":"rich","meta":{"author":"kes 🇵🇸","author_url":"https://twitter.com/joesnicky","cache_age":86400,"description":"watching the substance. i think this director just really likes asses— kes 🇵🇸 (@joesnicky) October 16, 2024\n\n\n","options":{"_maxwidth":{"label":"Adjust width","placeholder":"220-550, in px","value":""},"_theme":{"value":"","values":{"dark":"Use dark theme"}}},"provider_name":"Twitter","title":"kes 🇵🇸 on Twitter / X","type":"rich","url":"https://twitter.com/joesnicky/status/1846354786125599178","version":"1.0"},"flags":[],"enhancements":{},"fullBleed":false,"options":{"theme":"news","device":"desktop","editionInfo":{"id":"uk","name":"U.K.","link":"https://www.huffingtonpost.co.uk","locale":"en_GB"},"originalEdition":"uk","isMapi":false,"isAmp":false,"isAdsFree":false,"isVideoEntry":false,"isEntry":true,"isMt":false,"entryId":"67b5d41ae4b04083cc9994da","entryPermalink":"https://www.huffingtonpost.co.uk/entry/the-substance-director-talks-butt-shots_uk_67b5d41ae4b04083cc9994da","entryTagsList":"ukfilm,the-substance,coralie-fargeat","sectionSlug":"entertainment","deptSlug":null,"sectionRedirectUrl":null,"subcategories":"","isWide":false,"headerOverride":null,"noVideoAds":false,"disableFloat":false,"isNative":false,"commercialVideo":{"provider":"custom","site_and_category":"uk.entertainment","package":null},"isHighline":false,"vidibleConfigValues":{"cid":"60afc140cf94592c45d7390c","disabledWithMapiEntries":false,"overrides":{"all":"60b8e525cdd90620331baaf4"},"whitelisted":["56c5f12ee4b03a39c93c9439","56c6056ee4b01f2b7e1b5f35","59bfee7f9e451049f87f550b","5acccbaac269d609ef44c529","570278d2e4b070ff77b98217","57027b4be4b070ff77b98d5c","56fe95c4e4b0041c4242016b","570279cfe4b06d08e3629954","5ba9e8821c2e65639162ccf1","5bcd9904821576674bc55ced","5d076ca127f25f504327c72e","5b35266b158f855373e28256","5ebac2e8abddfb04f877dff2","60b8e525cdd90620331baaf4","60b64354b171b7444beaff4d","60d0d8e09340d7032ad0fb1a","60d0d90f9340d7032ad0fbeb","60d0d9949340d7032ad0fed3","60d0d9f99340d7032ad10113","60d0daa69340d7032ad104cf","60d0de02b627221e9d819408"],"playlists":{"default":"57bc306888d2ff1a7f6b5579","news":"56c6dbcee4b04edee8beb49c","politics":"56c6dbcee4b04edee8beb49c","entertainment":"56c6e7f2e4b0983aa64c60fc","tech":"56c6f70ae4b043c5bdcaebf9","parents":"56cc65c2e4b0239099455b42","lifestyle":"56cc66a9e4b01f81ef94e98c"},"playerUpdates":{"56c6056ee4b01f2b7e1b5f35":"60b8e525cdd90620331baaf4","56c5f12ee4b03a39c93c9439":"60d0d8e09340d7032ad0fb1a","59bfee7f9e451049f87f550b":"60d0d90f9340d7032ad0fbeb","5acccbaac269d609ef44c529":"60d0d9949340d7032ad0fed3","5bcd9904821576674bc55ced":"60d0d9f99340d7032ad10113","5d076ca127f25f504327c72e":"60d0daa69340d7032ad104cf","5ebac2e8abddfb04f877dff2":"60d0de02b627221e9d819408"}},"connatixConfigValues":{"defaultPlayer":"8b034f64-513c-4987-b16f-42d6008f7feb","clickToPlayPlayer":"5a777b9b-81fe-41a6-8302-59e9953ee8a2","videoPagePlayer":"19654b65-409c-4b38-90db-80cbdea02cf4"},"topConnatixThumnbailSrc":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR42mNkYAAAAAYAAjCB0C8AAAAASUVORK5CYII=","customAmpComponents":[],"ampAssetsUrl":"https://amp.assets.huffpost.com","videoTraits":null,"positionInUnitCounts":{"buzz_head":{"count":0},"buzz_body":{"count":0},"buzz_bottom":{"count":0}},"positionInSubUnitCounts":{"article_body":{"count":8},"blog_summary":{"count":0},"before_you_go_content":{"count":0}},"connatixCountsHelper":{"count":0},"buzzfeedTracking":{"context_page_id":"67b5d41ae4b04083cc9994da","context_page_type":"buzz","destination":"huffpost","mode":"desktop","page_edition":"en-uk"},"tags":[{"name":"ukfilm","slug":"ukfilm","links":{"relativeLink":"news/ukfilm","permalink":"https://www.huffingtonpost.co.uk/news/ukfilm","mobileWebLink":"https://www.huffingtonpost.co.uk/news/ukfilm"},"section":{"title":"Entertainment","slug":"entertainment"},"topic":{"title":"Film","slug":"ukfilm","overridesSectionLabel":false},"url":"https://www.huffingtonpost.co.uk/news/ukfilm/"},{"name":"the substance","slug":"the-substance","links":{"relativeLink":"news/the-substance","permalink":"https://www.huffingtonpost.co.uk/news/the-substance","mobileWebLink":"https://www.huffingtonpost.co.uk/news/the-substance"},"url":"https://www.huffingtonpost.co.uk/news/the-substance/"},{"name":"coralie fargeat","slug":"coralie-fargeat","links":{"relativeLink":"news/coralie-fargeat","permalink":"https://www.huffingtonpost.co.uk/news/coralie-fargeat","mobileWebLink":"https://www.huffingtonpost.co.uk/news/coralie-fargeat"},"url":"https://www.huffingtonpost.co.uk/news/coralie-fargeat/"}],"isLiveblogLive":null,"isLiveblog":false,"cetUnit":"buzz_body","bodyAds":["
Well, Coralie has finally shared her take on why her work focusses so heavily on people’s posteriors (it’s been noted that her first film, Revenge, uses similar framing techniques).
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The Oscar nominee told Letterboxd: “The ass is a very strong symbol of how [a woman’s body] is not neutral in the public space. How our body is constantly scrutinised, has been shaped to please the man’s eyes, has been seen as a body part that was objectified, that was detached from the person who was simply bearing it.”
Margaret Qualley, Coralie Fargeat and Demi Moore at the premiere of The Substance last year
via Associated Press
She went on to say that The Substance uses so many bum close-ups as a way of inviting viewers to think about “how much it is the focus of so many different gazes that we have to live with, that we have to take into account, that we have to endure”.
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“That’s something that has defined the way we can inhabit the public space,” she explained. ”[That] shapes a lot of our behaviour.”
Coralie added: “It represents the way a woman should be totally free and entitled to use her body the way she wants, to show it if she wants, to be as sexy as she wants, to be totally at ease and happy, to be whoever, however, whatever she wants.
“To get to this place with real freedom without it being an injunction, without it being something that you reproduce because you feel that it’s your only way to exist… That’s what those shots represent to me.”
As well as specific nominations for Demi Moore and its director, The Substance is also in the running for Best Picture – a rare feat for a horror flick – as well as Best Original Screenplay and Best Makeup And Hairstyling.
Boris Johnson is charging people more than £120 for a meet and greet in Scotland this September.
The former Conservative prime minister is already charging between £53.90 and £159.50 for tickets just for the public to attend “An Evening with Boris Johnson”, a live show at Edinburgh’s Usher Hall on September 2.
According to the event page, Johnson is known for “enacting the will of the British people” over Brexit and unleashing a “visionary agenda of domestic policy reform”.
Johnson also helped to “protect the union of England, Wales, Scotland and Northern Ireland,” the advert on Usher Hall’s website says – although the Brexit vote actually helped to elevate the cause of Scottish independence.
Johnson, now a columnist for the Daily Mail, is then described as a “pre-eminent global leader in the effort to support Ukraine in its fight against Russian invasion”, and “considered by the Kremlin as enemy number one”.
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He is also praised for leading the UK “through the darkest days of the pandemic” on the event page.
The former prime minister was ousted from office halfway through his term when ministers from his own government started to resign en masse over his leadership.
Johnson was ejected in July 2022 for a number of scandals, including being fined for breaching his own government’s social distancing rules during the Covid lockdown.
He resigned as the Uxbridge and South Ruislip MP the following year, shortly before an investigation into the partygate scandal found he had deliberately misled MPs by alleging Covid rules were followed at all times in Downing Street.
Among them have been a religion-obsessed recluse in the horror film Heretic, an eccentric thespian in Paddington 2 and, infamously, an Oompa Loompa in the movie musical Wonka.
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Throughout it all, though, Hugh says he’s been choosy about the roles that he selects, turning down anything he thinks has been “insufficient in quality or independence allowed to the filmmakers”.
And that’s why he was so bemused when one of his more recent movies underperformed at the box office.
Speaking to Vanity Fair last year to promote Heretic, Hugh was asked about Dungeons & Dragons: Honor Among Thieves, in which he played the conniving scam artist Forge Fitzwilliam.
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Hugh Grant in 2023’s Dungeons & Dragons: Honor Among Thieves
PARAMOUNT PICTURES/Moviestore/Shutterstock
Despite largely glowing reviews (including from Hugh himself, who maintains it is “such a good film”), the adventure movie was described by some critics as a “box office bomb”, which the Bafta winner admitted he’s still perplexed by.
“It’s the biggest mystery to me,” the British star admitted, questioning: “Why didn’t anyone do market research before?”
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Hugh continued: “I think that’s what went wrong: Basically, people just thought, I don’t want to see a film about this game. Why had no one asked the public?”
The Love Actually star can currently be seen in the new Bridget Jones sequel Mad About The Boy, reprising the role of Daniel Cleaver from the first two films.
Meeting the minimum requirement for vitamin B12, needed to make DNA, red blood cells and nerve tissue, may not actually be enough — particularly if you are older. It may even put you at risk for cognitive impairment.
A new study, led by UC San Francisco researchers, found that older, healthy volunteers, with lower concentrations of B12, but still in the normal range, showed signs of neurological and cognitive deficiency. These levels were associated with more damage to the brain’s white matter — the nerve fibers that enable communication between areas of the brain — and test scores associated with slower cognitive and visual processing speeds, compared to those with higher B12.
The study published in Annals of Neurology on Feb. 10.
The researchers led by senior author Ari J. Green, MD, of the UCSF Departments of Neurology and Ophthalmology and the Weill Institute for Neurosciences, said that the results raise questions about current B12 requirements and suggest the recommendations need updating.
“Previous studies that defined healthy amounts of B12 may have missed subtle functional manifestations of high or low levels that can affect people without causing overt symptoms,” said Green, noting that clear deficiencies of the vitamin are commonly associated with a type of anemia. “Revisiting the definition of B12 deficiency to incorporate functional biomarkers could lead to earlier intervention and prevention of cognitive decline.”
Lower B12 correlates with slower processing speeds, brain lesions
In the study, researchers enrolled 231 healthy participants without dementia or mild cognitive impairment, whose average age was 71. They were recruited through the Brain Aging Network for Cognitive Health (BrANCH) study at UCSF.
Their blood B12 amounts averaged 414.8 pmol/L, well above the U.S. minimum of 148 pmol/L. Adjusted for factors like age, sex, education and cardiovascular risks, researchers looked at the biologically active component of B12, which provides a more accurate measure of the amount of the vitamin that the body can utilize. In cognitive testing, participants with lower active B12 were found to have slower processing speed, relating to subtle cognitive decline. Its impact was amplified by older age. They also showed significant delays responding to visual stimuli, indicating slower visual processing speeds and general slower brain conductivity.
MRIs revealed a higher volume of lesions in the participants’ white matter, which may be associated with cognitive decline, dementia or stroke.
While the study volunteers were older adults, who may have a specific vulnerability to lower levels of B12, co-first author Alexandra Beaudry-Richard, MSc, said that these lower levels could “impact cognition to a greater extent than what we previously thought, and may affect a much larger proportion of the population than we realize.” Beaudry-Richard is currently completing her doctorate in research and medicine at the UCSF Department of Neurology and the Department of Microbiology and Immunology at the University of Ottawa.
“In addition to redefining B12 deficiency, clinicians should consider supplementation in older patients with neurological symptoms even if their levels are within normal limits,” she said. “Ultimately, we need to invest in more research about the underlying biology of B12 insufficiency, since it may be a preventable cause of cognitive decline.”
For years, scientific divers at a research station in the Mediterranean Sea had a problem: at some point in every field season, local fish would follow them and steal food intended as experimental rewards. Intriguingly these wild fish appeared to recognize the specific diver who had previously carried food, choosing to follow only them while ignoring other divers. To find out if that was true, a team from the Max Planck Institute of Animal Behavior (MPI-AB) in Germany conducted a series of experiments while wearing a range of diving gear, finding that fish in the wild can discriminate among humans based on external visual cues.
The experiments were designed to answer a question never before asked of wild fish: are they capable of telling people apart? Overall, little scientific evidence exists to show that fish can recognize humans at all. One captive-bred species, archerfish, was able to recognize computer-generated images of human faces in laboratory experiments. “But nobody has ever asked whether wild fish have the capacity, or indeed motivation, to recognize us when we enter their underwater world,” says Maëlan Tomasek, a doctoral student at MPI-AB and the University of Clermont Auvergne, France.
Now, a team from MPI-AB have asked; and the fish have responded. Wild fish can recognize individual humans. And, more than that, they follow specific divers they know will reward them. This finding, published in Biology Letters, lends credence to the possibility that fish can have differentiated relationships with specific humans.
The fish who volunteered
The research team conducted the study eight meters underwater at a research site in the Mediterranean Sea where populations of wild fish have become habituated to the presence of scientists. Their experiments took place in open water and fish participated in trials as “willing volunteers who could come and go as they pleased,” explains Katinka Soller, a bachelor student from MPI-AB who was co-first author on the study with Tomasek.
The first experimental phase — the training — tested if fish could learn to follow an individual diver. The training diver, Soller, started by trying to attract the attention of local fish; she wore a bright red vest and fed fish while swimming a length of 50 meters. Over time, Soller removed the conspicuous cues until she wore plain dive gear, kept the food hidden, and fed fish only after they had followed her the full 50 meters.
Of dozens of fish species inhabiting the marine station, two species of seabream in particular willingly engaged in the training sessions. Sea bream are best known to us as fish that we buy to eat, yet they surprised the scientists by their curiosity and willingness to learn.
“Once I entered the water, it was a matter of seconds before I would see them swimming towards me, seemingly coming out of nowhere,” says Soller. Not only were bream learning to follow her, but the same individuals were showing up day after day to join the lessons. Soller even took to giving them names: “There was Bernie with two shiny silver scales on the back and Alfie who had a nip out of the tail fin,” she says.
After 12 days of training, roughly 20 fish were reliably following Soller on training swims and she could recognize several of them from physical traits. By identifying individual fish participating in the experiment, the stage was set for the next experimental phase: testing if these same fish could tell Soller apart from another diver.
The two-diver test
This time Soller dived with Tomasek whose dive gear differed slightly from hers, notably in some colorful parts of the wetsuit and fins. Both divers started at the same point and then swam in different directions. On the first day, the fish followed both divers equally. “You could see them struggling to decide who to chase,” says Soller.
But Tomasek never fed the fish who followed him, so from the second day, the number of fish following Soller increased significantly. To confirm that fish were learning to recognize the correct diver, the researchers focused on six fish out of the large group to study individually, finding that four of these showed strong positive learning curves over the experiment. “This is a cool result because it shows that fish were not simply following Katinka out of habit or because other fish were there,” says Tomasek. “They were conscious of both divers, testing each one and learning that Katinka produced the reward at the end of the swim.”
But when Soller and Tomasek repeated the trials, this time wearing identical diving gear, the fish were unable to discriminate them. For the scientists, this was strong evidence that fish had associated the differences in the dive gear, most likely the colors, with each diver. “Almost all fish have color vision, so it is not surprising that the sea bream learned to associate the correct diver based on patches of color on the body,” says Tomasek.
Fish know how we look
Underwater, we do the same. “Faces are distorted by diving masks, so we usually rely on differences between wetsuits, fins, or other parts of the gear to recognize each other,” says Soller. With more time, the authors say, fish might have learned to pay attention to subtler human features, like hair or hands, to distinguish divers. “We already observed them approaching our faces and scrutinizing our bodies,” adds Soller. “It was like they were studying us, not the other way around.”
This study corroborates many anecdotal reports of animals, including fish, recognizing humans; but it goes further by performing dedicated experiments in completely natural contexts. Finding that wild fish can quickly learn to use specific cues to recognize individual human divers, it stands to reason that many other fish species, our pets included, can recognize certain patterns to identify us, the scientists say. This mechanism is the foundation for special interactions between individuals, even across species.
Senior author Alex Jordan, who leads a group at MPI-AB, says: “It doesn’t come a shock to me that these animals, which navigate a complex world and interact with myriad different species every minute, can recognize humans based on visual cues. I suppose the most surprising thing is that we would be surprised they can. It suggests we might underestimate the capacities of our underwater cousins.”
Adds Tomasek: “It might be strange to think about humans sharing a bond with an animal like a fish that sits so far from us on the evolutionary tree, that we don’t intuitively understand. But human-animal relationships can overcome millions of years of evolutionary distance if we bother to pay attention. Now we know that they see us, it’s time for us to see them.”
All humans need clean water to live. However, purifying water can be energy-intensive, so there is great interest in improving this process. Researchers at Tohoku University have reported a strategy using data-driven predictions coupled with precise synthesis to accelerate the development of single-atom catalysts (SACs) for more robust and efficient water purification.
SACs are one of the most crucial catalysts. They play a pivotal role in enhancing efficiency in diverse applications including chemical industries, energy conversion, and environmental processes. For water purification in particular, SACs can overcome the limitations of traditional heterogeneous catalysts such as the kinetics, catalytic selectivity, and stability — paving a promising way for the advancement of efficient and sustainable water purification technologies.
However, the development of SACs frequently employs time-consuming trial-and-error methods, and the typical synthesis methods often lack a high level of control. To avoid a process that essentially involves taking shots in the dark, researchers took a data-driven approach where they rapidly and accurately predicted which SACs would have the best performance before even starting to make them. They compared 43 metals-N4 structures comprising transition and main group metal elements using a hard-template method.
Following this strategy, they determined that the best candidate was a well-designed Fe-SAC with a high loading of Fe-pyridine-N4 sites (~3.83 wt%) and highly mesoporous structure. It successfully exhibited ultra-high decontamination performance (rate constant of 100.97 min-1 g-2).
“The optimized Fe-SAC can also continuously operate for 100 hours,” remarks Associate Professor Hao Li of WPI-AIMR, “To our knowledge, this represents one of the best performances of wastewater purification on Fenton-like catalysts — which are reagents used for water purification — reported so far.”
Density functional theory calculations revealed that the underlying mechanism was that the SAC reduced the energy barrier of the rate-determining step, which is intermediate O* formation. This resulted in the highly selective generation of singlet oxygen, which has been shown to break down pollutants to help purify water.
To make sure the data-driven prediction had accurately selected this “best” candidate, the research team looked at five other metals-N4 structures (i.e., Fe, Co, Ni, Cu, and Mn) with different theoretical activities. They confirmed that Fe-SAC truly exhibited the most excellent Fenton-like performance among the five selected SACs, agreeing well with the data-driven prediction.
The close integration of a data-driven method with a precise synthesis strategy provides a novel paradigm for the rapid development of high-performance catalysts for environmental fields, and other fields that involve sustainable energy and catalysis. Moving forward, they aim to develop an efficient and user-friendly workflow for the rapid and effective design of catalysts.
Those interested in incorporating the method into their own work can view the experimental data and computational structures in the Digital Catalysis Platform (DigCat): the largest experimental catalysis database reported to date, developed by the Hao Li Lab. The findings were also published in Angewandte Chemie International Edition on January 31, 2025.
The article processing charge (APC) was supported by the Tohoku University Support Program.
With a week to go until the new series gets underway, David has shared some of the stars he’ll be speaking to – including one guest that’ll be music to the ears of Doctor Who fans.
Russell was showrunner of Doctor Who during David’s first stint in the Tardis, and oversaw the anniversary specials that brought him back as the Fourteenth Doctor.
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He also wrote shows like Queer As Folk, Years And Years and It’s A Sin.
Russell T Davies at Comic-Con last year
via Associated Press
David quipped: “Yes, I know, just what the world needs… more podcast episodes. But with a line-up this good, I couldn’t resist coming back for season three.
“These guests are top-notch and you won’t want to miss a single one. And as for the finale…we don’t talk about the finale. Let’s just say it’s a series first.”
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David originally launched his podcast in 2019, interviewing the likes of Olivia Colman, Dame Judi Dench, James Corden and Doctor Who co-stars Billie Piper and Catherine Tate across its two seasons.
Other guests have included Tina Fey, Sir Brian Cox, Jennifer Garner, Schitt’s Creek star Dan Levy, Star Trek icon George Takei and former prime minister Gordon Brown.
