In a study led by researchers at NYU Grossman School of Medicine, in cooperation with 25 mostly US and British hospitals, some survivors of cardiac arrest described lucid death experiences that occurred while they were seemingly unconscious. Despite immediate treatment, fewer than 10% of the 567 patients studied, who received CPR in the hospital, recovered sufficiently to be discharged. Four in 10 of patients who survived, however, recalled some degree of consciousness during CPR not captured by standard measures.

The study also found that in a subset of these patients, who received brain monitoring, nearly 40% had brain activity that returned to normal, or nearly normal, from a “flatline” state, at points even an hour into CPR. As captured by EEG, a technology that records brain activity with electrodes, the patients saw spikes in the gamma, delta, theta, alpha, and beta waves associated with higher mental function.

Survivors have long reported having heightened awareness and powerful, lucid experiences, say the study authors. These have included a perception of separation from the body, observing events without pain or distress, and a meaningful evaluation of their actions and relationships. This new work found these experiences of death to be different from hallucinations, delusions, illusions, dreams, or CPR-induced consciousness.

The study authors hypothesize that the “flatlined,” dying brain removes natural inhibitory (braking) systems. These processes, known collectively as disinhibition, may open access to “new dimensions of reality,” they say, including lucid recall of all stored memories from early childhood to death, evaluated from the perspective of morality. While no one knows the evolutionary purpose of this phenomenon, it “opens the door to a systematic exploration of what happens when a person dies.”

Senior study author Sam Parnia, MD, PhD, associate professor in the Department of Medicine at NYU Langone Health and director of critical care and resuscitation research at NYU Langone, says, “Although doctors have long thought that the brain suffers permanent damage about 10 minutes after the heart stops supplying it with oxygen, our work found that the brain can show signs of electrical recovery long into ongoing CPR. This is the first large study to show that these recollections and brain wave changes may be signs of universal, shared elements of so-called near-death experiences.”

Dr. Parnia adds, “These experiences provide a glimpse into a real, yet little understood dimension of human consciousness that becomes uncovered with death. The findings may also guide the design of new ways to restart the heart or prevent brain injuries and hold implications for transplantation.”

Called the AWAreness during REsuscitation (AWARE)-II study — it followed 567 men and women who suffered cardiac arrest during hospital stays between May 2017 and March 2020 in the United States and United Kingdom. Only hospitalized patients were enrolled to standardize the CPR and resuscitation methods used, as well as recording methods for brain activity. A subset of 85 patients received brain monitoring during CPR. Additional testimony from 126 community survivors of cardiac arrest with self-reported memories was also examined to provide greater understanding of the themes related to the recalled experience of death.

The study authors conclude that research to date has neither proved nor disproved the reality or meaning of patients’ experiences and claims of awareness in relation to death. They say the recalled experience surrounding death merits further empirical investigation and plan to conduct studies that more precisely define biomarkers of clinical consciousness and that monitor the long-term psychological effects of resuscitation after cardiac arrest.

Infrared imaging is powerful in studying newborn stars and their outflows, because such stars are invariably still embedded within the gas from the molecular cloud in which they formed. The infrared emission of the star’s outflows penetrates the obscuring gas and dust, making a Herbig-Haro object like HH 211 ideal for observation with Webb’s sensitive infrared instruments. Molecules excited by the turbulent conditions, including molecular hydrogen, carbon monoxide, and silicon monoxide, emit infrared light that Webb can collect to map out the structure of the outflows.

The image showcases a series of bow shocks to the southeast (lower-left) and northwest (upper-right) as well as the narrow bipolar jet that powers them. Webb reveals this scene in unprecedented detail — roughly 5 to 10 times higher spatial resolution than any previous images of HH 211. The inner jet is seen to “wiggle” with mirror symmetry on either side of the central protostar. This is in agreement with observations on smaller scales and suggests that the protostar may in fact be an unresolved binary star.

Earlier observations of HH 211 with ground-based telescopes revealed giant bow shocks moving away from us (northwest) and moving towards us (southeast) and cavity-like structures in shocked hydrogen and carbon monoxide respectively, as well as a knotty and wiggling bipolar jet in silicon monoxide. Researchers have used Webb’s new observations to determine that the object’s outflow is relatively slow in comparison to more evolved protostars with similar types of outflows.

The team measured the velocities of the innermost outflow structures to be roughly 48-60 miles per second (80 to 100 kilometers per second). However, the difference in velocity between these sections of the outflow and the leading material they’re colliding with — the shockwave — is much smaller. The researchers concluded that outflows from the youngest stars, like that in the center of HH 211, are mostly made up of molecules, because the comparatively low shock wave velocities are not energetic enough to break the molecules apart into simpler atoms and ions.

Uncovering the organic (carbon-based) chemistry in interstellar space is central to understanding the chemistry of the universe in addition to the origin of life on Earth and the possibilities for life elsewhere.

The list of organic molecules detected in space and understanding how they could be interacting is steadily expanding due to ever-improving direct observations. But laboratory experiments unraveling the complex processes can also offer significant clues. Researchers at Hokkaido University, with colleagues at The University of Tokyo, Japan, report new lab-based insights into the central role of carbon atoms on interstellar ice grains in the journal Nature Astronomy.

Some of the most complex organic molecules in space are thought to be produced on the surface of interstellar ice gains at very low temperatures. Ice grains that are suitable for this purpose are known to be abundant throughout the universe.

All organic molecules are based on a skeleton of bonded carbon atoms. Most carbon atoms originally formed through nuclear fusion reactions in stars, eventually getting dispersed into interstellar space when the stars died in supernovae explosions. But to form complex organic molecules, the carbon atoms need a mechanism to come together on the surface of the ice grains to encounter partner atoms and form chemical bonds with them. The new research suggests a feasible mechanism.

“In our studies, recreating feasible interstellar conditions in the laboratory, we were able to detect weakly-bound carbon atoms diffusing on the surface of ice grains to react and produce C₂ molecules,” says chemist Masashi Tsuge of Hokkaido University’s Institute of Low Temperature Science. C₂ is also known as diatomic carbon, a molecule in which two carbon atoms bond together; its formation is concrete evidence for the presence of diffusing carbon atoms on interstellar ice grains.

The research revealed that the diffusion could occur at temperatures above 30 Kelvin (minus 243 °C/minus 405.4 °F), while, in space, the diffusion of carbon atoms could be activated at just 22 Kelvin (minus 251 °C/minus 419.8 °F).

Tsuge says that the findings bring a previously overlooked chemical process into the frame for explaining how more complex organic molecules could be built by the steady addition of carbon atoms. He suggests these processes could occur in the protoplanetary disks around stars, from which planets are formed. The conditions required can also form in so-called translucent clouds, which would eventually evolve into a star forming region. This may also explain the origin of the chemicals that might have seeded life on Earth.

Besides the question of the origin of life, the work adds a fundamental new process to the variety of chemical reactions that could have built, and could still be building, carbon-based chemistry throughout the universe.

The authors also summarize the more general current understanding of the formation of complex organic chemicals in space, and consider how reactions driven by diffusing carbon atoms might modify the current picture.