Mosquito-borne diseases becoming increasing risk in Europe

Experts say the insects, which carry viruses, have moved into new parts of the continent.

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Glastonbury, Leeds and Reading will have drug safety testing

The bosses of some large UK festivals say they will be checking drugs, but smaller events aren’t sure.

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Liver disease: ‘Poo transplant’ treatment trial launched

Participants will consume capsules of dried faeces to see if they can improve gut health.

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‘Infected blood killed my dad – I want compensation now’

Justine Gordon-Smith says her family were “abandoned” without support before her father’s death.

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UK Covid deaths among worst of big European economies

Death rates since March 2020 are up by 3% in France, 5% in the UK and 17% in the US.

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Rishi Sunak Says He’s ‘Completely Confident’ Of Beating Inflation

Rishi Sunak has said there is a “deep moral responsibility” to get inflation under control as the cost-of-living remains stubbornly high.

The prime minister’s characterisation came as official data on Wednesday showed inflation defied expectations that it would slow and held at 8.7% in May – making the rate of price growth in Britain the highest of any major economy once again.

It means the Bank of England is likely to hike interest rates again on Thursday in a desperate attempt to cool the economy down, spelling bad news for homeowners who face further increases in mortgage repayments. The central bank’s over-arching aim is to keep inflation at 2%.

Sunak vowed in January that the government would halve the rate at which prices are rising by the end of the year. At the time, the inflation rate was around 10%.

Speaking at an event on Thursday, Sunak will put an added emphasis on the goal.

He is expected to say: “I feel a deep moral responsibility to make sure the money you earn holds its value.

“That’s why our number one priority is to halve inflation this year and get back to the target of 2%.

“And I’m completely confident that if we hold our nerve, we can do so.”

His comments suggest lowering inflation now trumps economic growth – one of Sunak’s other promises – which could have other negative economic impacts.

Acknowledging that this is a difficult time for families and businesses, the prime minister will add: “Beating inflation has to be the priority … because if we don’t get a grip on inflation now, the damage will be worse and longer lasting.”

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Jon Hamm Opens Up About Engagement To Anna Osceola

Jon Hamm, who got engaged in February, is finally in “a pretty good place”.

While the 52-year-old Mad Men star met Anna Osceola while shooting the show’s finale in 2015, they were only first linked romantically in 2020. Hamm said finding the right partner wasn’t easy, but that his 35-year-old fiancée is one he can finally “lean on”.

“I think when you’re figuring out relationships, there’s a reason that that’s a genre unto itself in television and film,” he told People in an interview published Wednesday. “It’s a bumpy road towards relationships, but we do get better at it, I suppose.”

Osceola, a fellow actor, most recently starred opposite Hamm in the 2022 detective comedy, Confess, Fletch. Hamm previously dated Jennifer Westfeldt, but notably split with her after 18 years in 2015 — the year he met Osceola.

“I feel like I’ve figured out some things over the course of my half a century on the planet,” he said. “So I’m in a pretty good place now. Hopefully I’m learning.”

Hamm, whose parents divorced when he was two years old, didn’t have it easy. He lost his mother to colon cancer when he was 10, and later his father died when he was 20. Hamm found solace in acting at college, and revealed in 2017 he finally started going to therapy.

Jon Hamm and Anna Osceola first met while shooting the “Mad Men” series finale in 2015.
Jon Hamm and Anna Osceola first met while shooting the “Mad Men” series finale in 2015.

Evan Agostini/Invision/Associated Press

“It’s only been in the last couple of years, me kind of sitting down and really thinking about all that stuff, that’s made the relationship that I’m in now even more meaningful,” he told Howard Stern in 2022, adding he was open to “being married, having kids…happiness”.

While still challenging, Hamm finds life easier and more rewarding with Osceola by his side.

“You’re in it, it’s your life, and so you wake up and you deal with what comes at you,” he told People. “That’s certainly the case with us. The funny thing about this career is that there’s no rule book. You really have to lean on one another for…support and…any kind of advice.”

The trauma of losing one parent as a child and the other soon after oddly made Hamm the best candidate for his fractured Mad Men character of Don Draper. Hamm, who previously revealed he regularly abused alcohol in the past, is fortunately much happier today.

Living with another actor, meanwhile, has shown to be uniquely challenging on its own. Hamm said that he and Osceola handle those hurdles “day to day”, specially when the lines between work and home life appear too blurry to distinguish.

They currently star together in Maggie Moore(s) directed by Mad Men alum John Slattery.

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Isolating sooner might have avoided first lockdown, Hunt says

The UK should have prepared to test and isolate more, the ex-health secretary tells the Covid inquiry.

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So, Why Exactly Is Inflation Higher In Britain Than In The US And Europe?

The UK has an inflation problem. Officials had hoped the rising cost of goods and services would have been brought to heel by now, as soaring energy costs fuelled by the war in Ukraine have cooled.

But, on Wednesday, its downward trajectory stalled and alarm bells started ringing.

The Office for National Statistics said inflation, as measured by the consumer price index, held steady at 8.7 per cent in the year to May. Expectations were that the rate would fall a to 8.4 per cent.

And there was more. Britain’s measure of underlying inflation that excludes volatile items, such as energy and food, took investors by surprise by accelerating for a second month in a row in May, hitting 7.1 per cent, up from 6.8 per cent in April. Higher core inflation is seen as a sign that price growth is more likely to remain persistently high.

<img class="img-sized__img landscape" loading="lazy" alt="UK inflation remains unchanged at 8.7% in May.” width=”720″ height=”693″ src=”https://www.wellnessmaster.com/wp-content/uploads/2023/06/so-why-exactly-is-inflation-higher-in-britain-than-in-the-us-and-europe-2.jpg”>
UK inflation remains unchanged at 8.7% in May.

Anadolu Agency via Getty Images

It looks certain that the independent Bank of England will raise the cost of borrowing again on Thursday for the 13th month in a row – the only question is whether it’s by 0.25 percentage points, or a symbolic half percentage point to 5%.

Don’t other countries have inflation under control?

Britain’s inflation rate has stayed far above price growth in the US and elsewhere in Europe. Although 8.7% is down from a peak of 11.1% last October, it leaves the UK with the highest inflation rate among the G7 advanced economies. By comparison, inflation stood at 4% in the US and 6.1% across the 20 EU countries that use the euro currency.

Last week, the Federal Reserve – America’s equivalent of the Bank of England – ended a 15-month streak of hiking interest rates, a pause that currently seems highly unlikely in the UK.

The surging cost of food

Britain has had western Europe’s highest rate of inflation for food, with prices up more than 18 per cent over the past year, down only slightly from a recent peak of more than 19 per cent, the highest since 1977.

Freak weather has affected crops around the world, pushing up prices for many countries. But Britain is the world’s third largest net importer of food and drink, according to the Food and Agriculture Organisation of the United Nations – behind only China and Japan – leaving it particularly exposed.

Industry data published on Tuesday showed British grocery inflation eased slightly for the third month in a row in June.

Bank of England governor Andrew Bailey said last month that British food producers may have locked in higher costs than the central bank had anticipated, explaining some of its underestimate of inflation.

Heavy reliance on natural gas

Britain is highly reliant on imported gas to generate electricity, exposing it to the full force of the surge in gas prices last year after Russia’s invasion of Ukraine.

The way Britain regulates energy prices for domestic and business users – it announces changes to maximum tariffs on a quarterly basis – means that international price rises are slower to push up inflation than in many other countries but falls are also slower to feed through into bills for users.

Brexit

Exiting the European Union and its single market at the start of 2021 has started to have an impact. Although an agreement between the UK and the bloc allows largely tariff-free trade in goods, there are barriers to exports and imports in the form of paperwork which have caused delays and higher costs.

Meanwhile, the end of free movement of workers from EU countries has contributed to an acute shortage of staff for many employers, pushing up wages and ultimately prices for consumers.

Bank of England decision-making

Some economists think the Bank, which is tasked with keeping inflation at around 2%, was too slow in starting to raise interest rates and is now playing catch-up.

Its own monetary policy committee rate-setter member, Chaterine Mann, said in February that the Bank should have started raising interest rates earlier (“a greater degree of front-loading” was needed) and is now paying the price.

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Helping ‘good’ gut bacteria and clearing out the ‘bad’ — all in one treatment

Probiotics can help maintain a healthy gut microbiome or restore populations of “good bacteria” after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn’s disease. Researchers reporting in ACS Central Science have developed a microgel delivery system for probiotics that keeps “good” bacteria safe while actively clearing out “bad” ones. In mice, the system treated intestinal inflammation without side effects.

In the digestive system, there’s a delicate balance of bacterial populations. When this balance is disrupted, bad bacteria can take over the colon, causing it to swell, resulting in colitis. Certain diseases, including inflammatory bowel disease and Crohn’s disease, involve chronic colitis and currently require immunosuppressants to treat them. These drugs are expensive and non-specific, sometimes giving rise to antibiotic-resistant bacteria.

An alternative strategy is to deliver beneficial bacteria, or probiotics, to help restore balance. But to reach the colon, a treatment must first pass through stomach acid, withstand being cleared out by the intestine, then fight for space alongside the numerous invading bacteria. Pairing probiotics with a drug delivery system could make this strategy feasible, though most current approaches simply protect the probiotics from digestion without affecting the microbes responsible for the condition. So, Zhenzhong Zhang, Junjie Liu, Jinjin Shi and colleagues wanted to combine probiotics with specialized microgel spheres that could not only protect the good bacteria, but also actively help clear out the bad.

To create their system, the researchers combined sodium alginate, tungsten and calcium-containing nanoparticles into small, spherical microgels, then coated them with beneficial, probiotic bacteria. The gels protected the bacteria as they made their way through the stomach and increased their retention time in the colon. Once there, calprotectin proteins — highly expressed during colitis — bound to the calcium and disassembled the gels, allowing the tungsten to escape. By displacing molybdenum in a key enzyme substrate of the bad bacterium Enterobacteriaceae, tungsten inhibited the microbe’s growth while leaving the probiotics unaffected. In experiments using a colitis mouse model, the system allowed probiotics to proliferate in the intestine without any side effects. Additionally, mice with the microgel spheres did not exhibit many of the hallmarks of colitis, such as shortened colons or damaged intestinal barriers, showing that the delivery system could be a viable treatment strategy. Though the researchers also want to prove its utility in more advanced preclinical models, they say that this work provides a new perspective into treatments using colonizing probiotics.

The authors acknowledge funding from the National Natural Science Foundation of China, the Outstanding Youth Foundation of Henan Province and the China Postdoctoral Science Foundation.

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