Cognitive tests that rely on vision-dependent tasks could be skewing results in up to a quarter of people aged over 50 who have undiagnosed visual problems such as cataracts or age-related macular degeneration (AMD).

Age-related macular degeneration is a leading cause of vision loss for older people. It doesn’t cause complete vision loss, but severely impacts people’s ability to read, drive, cook, and even recognise faces. It has no bearing on cognition.

UniSA researchers recruited 24 participants with normal vision to complete two cognitive tests — one involving vision-dependent reactive tasks and the other based on verbal fluency.

Using a set of goggles to simulate AMD, the participants scored far lower on the cognitive test involving reaction time tasks than without the goggles. There was no statistical difference with verbal fluency tests when using the goggles.

The study has been published in Scientific Reports.

UniSA PhD candidate Anne Macnamara, who led the study, says the results are a stark reminder that visual impairments — which affect approximately 200 million people worldwide over the age of 50 — unfairly affect cognitive scores when tests involve visual abilities.

“A mistaken score in cognitive tests could have devastating ramifications, leading to unnecessary changes to a person’s living, working, financial or social circumstances,” Macnamara says.

“For example, if a mistaken score contributed to a diagnosis of mild cognitive impairment, it could trigger psychological problems including depression and anxiety.

“People with AMD are already experiencing multiple issues due to vision loss and an inaccurate cognitive assessment is an additional burden they don’t need.”

Visual impairments are often overlooked in research and clinical settings, the UniSA researchers say, with reduced vision underestimated in up to 50 per cent of older adults.

And with this figure expected to increase in line with an ageing population, it is critical that neuro-degenerative researchers control for vision when assessing people’s cognition.

“Mobile apps can now be used to overlay simulated visual impairments onto test materials when piloting their stimuli,” Macnamara says.

“Also, researchers can incorporate quick and simple screening tasks before getting people to do cognitive tests. Verbal tasks should always be part of the assessment, too.”

Story Source:

Materials provided by University of South Australia. Note: Content may be edited for style and length.

In a paper just published in the journal Advanced Materials, a team of scientists from Northwestern University and the U.S. Department of Energy’s Brookhaven National Laboratory describe the previously hidden sub-nanoscale origins of both the unusual shrinkage and the exceptional thermoelectric properties in this material, silver gallium telluride (AgGaTe₂). The discovery reveals a quantum mechanical twist on what drives the emergence of these properties — and opens up a completely new direction for searching for new high-performance thermoelectrics.

“Thermoelectric materials will be transformational in green and sustainable energy technologies for heat energy harvesting and cooling — but only if their performance can be improved,” said Hongyao Xie, a postdoctoral researcher at Northwestern and first author on the paper. “We want to find the underlying design principles that will allow us to optimize the performance of these materials,” Xie said.

Thermoelectric devices are currently used in limited, niche applications, including NASA’s Mars rover, where heat released by the radioactive decay of plutonium is converted into electricity. Future applications might include materials controlled by voltage to achieve very stable temperatures critical for operation of high-tech optical detectors and lasers.

The main barrier to wider adoption is the need for materials with just the right cocktail of properties, including good electrical conductivity but resistance to the flow of heat.

“The trouble is, these desirable properties tend to compete,” said Mercouri Kanadzidis, the Northwestern professor who initiated this study. “In most materials, electronic conductivity and thermal conductivity are coupled and both are either high or low. Very few materials have the special high-low combination.”

Under certain conditions, silver gallium telluride appears to have just the right stuff — highly mobile conducting electrons and ultra-low thermal conductivity. In fact, its thermal conductivity is significantly lower than theoretical calculations and comparisons with similar materials such as copper gallium telluride would suggest.

The Northwestern scientists turned to colleagues and tools at Brookhaven Lab to find out why.

“It took a meticulous x-ray examination at Brookhaven’s National Synchrotron Light Source II (NSLS-II) to reveal a previously hidden sub-nanoscale distortion in the positions of the silver atoms in this material,” said Brookhaven Lab physicist Emil Bozin, leader of the structural analysis.

Computational modeling revealed how those distortions trigger the one-axis crystal shrinkage — and how that structural shift scatters atomic vibrations, thus blocking the propagation of heat in the material.

But even with that understanding, there was no clear explanation of what was driving the sub-nanoscale distortions. Complementary computational modeling by Christopher Wolverton, a professor at Northwestern, indicated a novel and subtle quantum mechanical origin for the effect.

Together the findings point to a new mechanism for turning down thermal conductivity and a new guiding principle in the search for better thermoelectric materials.

Mapping atomic positions

The team used x-rays at NSLS-II’s Pair Distribution Function (PDF) beamline to map out the “large” scale arrangement of atoms in both copper gallium telluride and silver gallium telluride over a range of temperatures to see if they could discover why these two materials behave differently.

“A stream of hot air heats the sample with degree-by-degree precision,” said Milinda Abeykoon, who is the lead scientist of the PDF beamline. “At each temperature, as the x-rays bounce off the atoms, they produce patterns that can be translated into high spatial resolution measurements of the distances between each atom and its neighbors (each pair). Computers then assemble the measurements into the most likely 3D arrangements of the atoms.”

The team also did additional measurements over a wider range of temperatures but at lower resolution using the light source at the Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany. And they extrapolated their results down to a temperature of absolute zero, the coldest anything can get.

The data show that both materials have a diamond-like tetragonal structure of corner-connected tetrahedra, one with a single copper atom and the other with silver at the center of the 3D object’s tetrahedral cavity. Describing what happened as these diamondlike crystals were heated, Bozin said, “Immediately we saw a big difference between the silver and copper versions of the material.”

The crystal with copper at its core expanded in every direction, but the one containing silver expanded along one axis while shrinking along another.

“This strange behavior turned out to have its origin in the silver atoms in this material having very large amplitude and disorderly vibrations within structural layers,” said Simon Billinge, a professor at Columbia University with a joint appointment as a physicist at Brookhaven. “Those vibrations cause the linked tetrahedra to jiggle and jump with large amplitude,” he said.

This was a clue that the symmetry — the regular arrangement of atoms — might be “broken” or disrupted at a more “local” (smaller) scale.

The team turned to computational modeling to see how various local symmetry distortions of the silver atoms would match with their data.

“The one that worked the best showed that the silver atom goes off center in the tetrahedron in one of four directions, toward the edge of the crystal formed by two of the tellurium atoms,” Bozin said. On average, the random, off-center shifts cancel out, so the overall tetragonal symmetry is retained.

“But we know the larger scale structure changes too, by shrinking in one direction,” he noted. “As it turns out the local and larger scale distortions are linked.”

Twisting tetrahedrons

“The local distortions are not completely random,” Bozin explained. “They are correlated among adjacent silver atoms — those connected to the same tellurium atom. These local distortions cause adjacent tetrahedra to rotate with respect to one another, and that twisting causes the crystal lattice to shrink in one direction.”

As the shifting silver atoms twist the crystal, they also scatter certain wavelike vibrations, called phonons, that allow heat to propagate through the lattice. Scattering AgGaTe₂‘s energy-carrying phonons keeps heat from propagating, dramatically lowering the material’s thermal conductivity.

But why do the silver atoms shift in the first place?

The Brookhaven scientists had seen similar behavior a decade earlier, in a rock-salt like lead-telluride material. In that case, as the material was heated, “lone pairs” of electrons formed, generating tiny areas of split electric charge, called dipoles. Those dipoles pulled centrally located lead atoms off center and scattered phonons.

“But in silver gallium telluride there are no lone pairs. So, there must be something else in this material — and probably other ‘diamondoid’ structures as well,” Bozin said.

Bending bonding behavior

Christopher Wolverton’s calculations at Northwestern revealed that “something else” to be the bonding characteristics of the electrons orbiting the silver atoms.

“Those calculations compared the silver and copper atoms and found that there is a difference in the arrangement of electrons in the orbitals such that silver has a tendency to form weaker bonds than copper,” said Northwestern’s Xie. “Silver wants to bond with fewer neighboring tellurium atoms; it wants a simpler bonding environment.”

So instead of binding equally with all four surrounding tellurium atoms, as copper does, silver tends to preferentially (but randomly) move closer to two of the four. Those bonding electrons are what pull the silver atom off center, triggering the twisting, shrinkage, and vibrational changes that ultimately lower thermal conductivity in AgGaTe_2.

“We’ve stumbled upon a new mechanism by which lattice thermal conductivity can be reduced,” Northwestern’s Mercouri Kanadzidis said. “Perhaps this mechanism can be used to engineer, or look for, other new materials that have this type of behavior for future high-performance thermoelectrics.”

This research was primarily supported by the DOE Office of Science. NSLS-II is a DOE Office of Science user facility.

By studying the tendency of fish to return to their place of birth to reproduce — a concept known as philopatry that is often, and falsely, thought to apply only to salmon species — and pairing such knowledge with catch distribution maps and tagging and genetic sequencing studies, researchers at UBC’s Sea Around Us initiative identified the tentative migration routes of 11 tuna and other large pelagic fish in the Pacific Ocean and determined that certain areas should be considered as of ‘high’ and ‘very high’ priority when it comes to maintaining their populations.

“We applied the concept of philopatry to the movements extracted from tagging studies of species such as the near-threatened Pacific bluefin tuna and the heavily-fished yellowfin tuna, and we also combined this information with the links between populations inferred from genetic studies. This allowed us to identify tentative annual migration cycles,” said Veronica Relano, a doctoral candidate with the Sea Around Us and lead author of thestudy that presents these findings.

“The interesting thing is that when we compared our proposed migration routes and the mapped catch data from 1950 to 2016 available on the Sea Around Us website, we found many coincidences. Clearly, the accuracy of these routes is reinforced by considering philopatry, although they are still tentative,” she said.

After analyzing the seasonal migration paths of each of the 11 fish species individually, the researchers superposed them and noticed that several species and populations of these large pelagic fishes use the same migration routes.

“Those high-traffic areas, two of which are in northeastern and central sections of the Pacific Ocean and two in the southwestern and central sections, should become parts of blue corridors, which are routes where strict fisheries management measures or partial bans of industrial fishing ought to be enforced to allow for increased connectivity of habitats and thus allow populations of marine species to maintain themselves,” said Dr. Daniel Pauly, co-author of the study and the Sea Around Us principal investigator.

“But before setting up any protected area to support the rebuilding of diminished fish populations, it is important to consider the entire body of knowledge available on the migrations and movements of different species. This is what we set out to do with this study. Our findings suggest in which areas such efforts would be more effective, but as stated in our title, the closed migration cycles we propose are tentative, and thus it would be nice if other researchers set out to test their validity,” he said.

Story Source:

Materials provided by University of British Columbia. Note: Content may be edited for style and length.