Donald Trump’s former vice-president has slammed his decision to waive sanctions against Russia as the war in Ukraine goes on.
Mike Pence said the move “is decidedly not in the national interests of the United States and should be reversed”.
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The US Senate passed the Lindsey O. Graham Sanctioning Russia and Iran Act last month, and it was then signed into law by Trump himself.
It gave the president the power to impose extensive new tariffs and sanctions on Russia and countries that buy energy products and other critical exports from the country as its war on Ukraine continues.
But Trump announced he was blocking the new sanctions just two days before they were due to come into force.
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In a post on X, Pence – who has become a fierce critic of Trump – condemned the move.
He said: “President Trump’s decision to waive sanctions against Russia as Putin continues his brutal war of aggression against Ukraine dishonors the legacy of the late Senator Lindsey Graham and is decidedly not in the national interests of the United States and should be reversed.
“Putin is a war criminal and only understands strength. Waiving Graham Act sanctions on Russia signals weakness at a moment that demands American strength.
“Now is the time to stand strong against Russian aggression, just as we did during the years of the first Trump Administration.”
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Pence said that if Ukraine won the war, it “would be a victory for freedom and is squarely in the national interests of the United States”.
He added: “If Putin overruns Ukraine, I have no doubt it will only be a matter of time until Russia’s military crosses a border that our troops will have to deal with him.
“For the cause of freedom, for America’s national security and that of our allies including Ukraine, President Trump should restore sanctions under the Graham Act immediately, rescind the diesel deal with Russia and rally our allies to ensure Ukraine has the military support it needs to repel and defeat this Russian invasion once and for all.”
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President Trump’s decision to waive sanctions against Russia as Putin continues his brutal war of aggression against Ukraine dishonors the legacy of the late Senator Lindsey Graham and is decidedly not in the national interests of the United States and should be reversed.
Trump has faced accusations that he limited Ukraine’s access to the Starshield network which helps to protect the country from Russian attacks.
The president has also called for Ukrainian president Volodymyr Zelenskyy to be replaced while agreeing a sanctions-busting deal with Vladimir Putin to buy Russian diesel.
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Critics have said that is a desperate attempt to bring down pump prices for American motorists ahead of next month’s midterm elections, which Trump’s Republican Party is expected to lose heavily.
Listen to Commons People, the podcast that makes politics easy. Every week, Kevin Schofield and Kate Nicholson unpack the week’s biggest stories to keep you informed. Join us for straightforward analysis of what’s going on at Westminster.
Physicists have uncovered a strange new form of quantum behavior in which particles organize themselves in ways that challenge established theories. Even more surprising, the particles maintain a remarkable hidden order despite being driven into an extremely energetic state.
In a study published in Physical Review Letters, researchers from the group led by Hanns-Christoph Nägerl, working with theoretical physicist Alvise Bastianello of the CNRS and Université Paris-Dauphine, describe how to engineer an exotic quantum state known as a “fractional Fermi sea.”
The breakthrough involves pushing ultracold cesium atoms far beyond their normal conditions by repeatedly changing how strongly they attract or repel one another. Rather than simply becoming disordered, the particles rearrange themselves into an unusual configuration that behaves differently from the quantum systems scientists have traditionally studied.
The theoretical findings provide the foundation for recent experimental research conducted by Nägerl’s team at the Department of Experimental Physics.
Pushing Quantum Particles Beyond Their Normal Limits
Under ordinary conditions, quantum particles follow well-established rules that determine how they arrange themselves, particularly at extremely low temperatures.
One important example involves fermions, a category of particles that includes electrons. These particles cannot all occupy the same quantum state, so they fill available energy levels according to specific restrictions. At very low temperatures, this arrangement produces what physicists call a Fermi sea.
But what happens when researchers deliberately disrupt the conditions that normally govern how particles behave?
As Alvise Bastianello explains: “Fermions, for instance, stack neatly into the available energy states to form the so-called ‘Fermi sea’. But what happens if one forces interacting atoms to continuously cycle through extreme conditions, smoothly shifting them from strongly repelling each other to strongly attracting each other?”
To investigate this possibility, the researchers studied ultracold cesium atoms confined to a one-dimensional system. This means the atoms are restricted to moving along a single direction, creating an environment in which their quantum interactions can be studied with exceptional control.
The team examined what happens when the interactions between these atoms are repeatedly adjusted, cycling between powerful repulsion and attraction.
Their calculations revealed something unexpected. Starting from the ground state, the lowest energy configuration available to the system, the atoms could be driven into a highly excited state without losing their underlying organization.
The researchers call this unusual arrangement a fractional Fermi sea because its particles appear to obey a modified rule governing how quantum states are occupied.
“Instead of simply heating the system, the interaction cycle reorganizes the atoms into a new many-body state,” says Yi Zeng, the leading author of this study. “This gives us a controlled way to explore quantum matter beyond the usual equilibrium paradigms.”
A Strange New Quantum State With Hidden Order
One of the most intriguing features of the fractional Fermi sea is that its particles remain organized even though the system has been pushed far from equilibrium.
In physics, equilibrium describes a condition in which a system’s overall properties have settled into a stable balance. Systems driven far from equilibrium can behave in complicated and unexpected ways, making them particularly challenging to understand.
Yet the fractional Fermi sea is not simply a collection of excited particles behaving randomly. Instead, it contains distinctive mathematical patterns that reveal a deeper structure.
Among these patterns are pronounced ripples called Friedel oscillations. These are wave-like variations associated with the way quantum particles influence one another. The researchers also identified unusual patterns in how correlations between particles weaken with increasing distance, even when the repulsive interactions are relatively weak.
These signatures are important because they differ from predictions associated with Tomonaga-Luttinger liquid theory, a long-established framework for describing how interacting quantum particles behave in one-dimensional systems.
The findings therefore point toward a previously unexplored type of quantum behavior that cannot be fully described using this familiar theoretical picture.
“This state is highly excited, but it is not random,” says Hanns-Christoph Nägerl, the group leader. “It has a hidden order that becomes visible in its correlations.”
The strange behavior also raises questions about the effective particles that emerge within the system. Physicists call these collective excitations quasiparticles because they can behave like individual particles even though they arise from the coordinated motion of many interacting particles.
Nägerl suggests that the unusual excitations might eventually deserve a name of their own.
“We are not yet sure how we should name these new quasiparticles. Perhaps ‘super-Fermions’?”
Opening a New Frontier in Quantum Physics
The discovery suggests that fractional Fermi seas represent an exotic critical phase of quantum matter, with characteristic patterns of particle correlations that extend beyond existing descriptions of one-dimensional quantum systems.
It also demonstrates the growing power of quantum simulation, a technique that allows scientists to use carefully controlled quantum systems to investigate physical behavior that would otherwise be difficult to reproduce or study.
Ultracold atoms are particularly useful for this purpose because researchers can precisely adjust their interactions and observe how the resulting quantum states change.
Rather than limiting these experiments to recreating phenomena already understood through established theories, scientists can now explore deliberately engineered states that reveal entirely new possibilities.
As Hanns-Christoph Nägerl says: “The discovery of fractional Fermi seas shows how far we can push quantum simulation: not only reproducing known models, but creating and probing states that go beyond established paradigms.”
The current publication establishes the theoretical framework for fractional Fermi seas. A companion study describing their experimental realization through quantum simulation is undergoing peer review.
Together, the research points toward new ways of investigating the fundamental behavior of quantum matter, including unusual collective excitations and hidden forms of order that emerge only when particles are pushed far outside their normal conditions.
Psilocybin, the psychedelic substance found in more than 200 species of mushrooms, appears to have an unexpected effect on aggressive fish. Most mushrooms containing this compound belong to the gilled mushroom genus Psilocybe. In mammals, psilocybin interacts with serotonin receptors in the brain, influencing emotions and behaviors such as mood, appetite, and aggression. However, scientists still know relatively little about how the substance affects social interactions among animals.
To investigate this question, researchers in Canada examined the effects of psilocybin on the amphibious mangrove rivulus fish (Kryptolebias marmoratus). Their findings, published in Frontiers in Behavioral Neuroscience, suggest that even a brief exposure to a low dose can significantly reduce aggressive behavior without disrupting normal social interactions.
“We show that an acute, low dose of psilocybin significantly reduces activity and aggressive attack behavior during social interactions in adult mangrove rivulus fish, a species that is naturally highly aggressive,” said first author Dayna Forsyth, a research associate and former MSc student at Acadia University in Nova Scotia.
“These findings provide the first evidence that psilocybin can selectively reduce escalated aggression in a vertebrate model without suppressing social interaction,” added senior author Dr. Suzie Currie, a biologist at The University of British Columbia.
Why Scientists Studied Aggressive Mangrove Rivulus Fish
Mangrove rivulus fish are naturally combative, particularly when they encounter another member of their species. Their aggressive responses are easy to recognize and measure, allowing researchers to detect even small changes in behavior.
These fish also have an unusual reproductive ability. They can fertilize themselves, producing offspring that are genetically identical. This makes them especially useful for experiments because scientists can minimize genetic variation and more confidently attribute behavioral differences to psilocybin rather than inherited traits.
For the experiment, the researchers worked with three genetically distinct lines of fish bred in the laboratory. One group received psilocybin, another provided the fish used to provoke social interactions, and the third helped researchers measure how much psilocybin entered and accumulated in the animals’ bodies.
The researchers first established a baseline for each fish’s behavior. They placed a fish into a tank already occupied by another fish, with the two separated by a fiberglass mesh barrier and an opaque cover. The mesh prevented physical contact while allowing the fish to see and smell each other once the cover was removed.
After allowing five minutes for the fish to adjust to their shared environment, the team removed the opaque cover and recorded their interactions.
The following day, 24 hours after the initial observation, the researchers placed the same fish in water containing dissolved psilocybin. Following 20 minutes of exposure, they returned it to the tank with the same fish it had encountered previously. The opaque cover was then removed again so the researchers could observe any changes in behavior.
The results revealed a striking change. Fish exposed to psilocybin moved around less and displayed fewer bursts of aggressive swimming than fish that had not received the substance.
To assess these changes, the scientists measured overall activity (time spent moving) and several signs of aggression (including swimming bursts). These rapid bursts are particularly important because they indicate that an encounter is escalating toward an attack, even when the fish cannot make physical contact.
“Swimming bursts are high-energy attack behaviors that represent an escalation of aggression towards the stimulus fish without making physical contact,” explained Currie. “Other types of aggressive behaviors, like head-on displays, are more about communication and social assessment and require very little energy.”
Interestingly, psilocybin did not suppress every form of aggressive or social behavior. While the fish became less likely to engage in intense, energy-demanding attacks, their less physically demanding social displays remained largely unchanged.
“Psilocybin’s calming effect appears to selectively reduce energetically costly, escalated behaviors while lower-energy social display behaviors remained largely unchanged,” said Forsyth. “This suggests that this compound can selectively dampen escalated social conflict rather than shutting down behavior altogether.”
The compound also reduced general activity. When placed alongside another member of their species, fish treated with psilocybin spent less time swimming than untreated controls.
Together, these findings suggest that psilocybin may influence specific aspects of aggressive behavior rather than simply making animals less responsive to their surroundings.
What the Findings Could Mean for Psychedelic Research
The researchers believe animal studies like this one could eventually help scientists better understand how psychedelic compounds influence behavior and identify possible directions for therapeutic research.
By examining which social responses are most sensitive to psilocybin, researchers may be able to uncover biological mechanisms that are difficult to investigate directly in people. Such insights could ultimately inform studies of potential clinical applications.
However, the team emphasized that the findings should not be interpreted as evidence of a treatment for aggression in humans. The experiment involved fish, did not evaluate any clinical intervention, and cannot establish whether similar effects would occur in people.
There are also important questions about how long the calming effect lasts. The researchers examined only single doses and short exposure periods. They did not investigate repeated treatments, long-term behavioral changes, or whether the fish might adapt to the substance over time.
Additional experiments will be necessary to determine whether psilocybin’s ability to reduce aggressive attacks can persist beyond the brief period examined in this study.
“Future studies can build on this work to explore how psilocybin alters neural signaling, which serotonin pathways are involved, and why some aspects of social behavior are affected while others are not,” concluded Currie. “These are questions that are difficult or impossible to answer directly in humans.”
Scientists have uncovered a previously unknown form of magnetism, overturning an understanding of magnetic behavior that had stood for more than a century. The discovery, known as altermagnetism, has revealed a third fundamental category of collinear magnetism and opened new possibilities for quantum materials, advanced electronics, and future computing technologies.
Three physicists responsible for the breakthrough have been named recipients of the 2026 Europhysics Prize, one of Europe’s most prestigious honors in condensed matter physics. The European Physical Society (EPS) Condensed Matter Division selected Professor Jairo Sinova of Johannes Gutenberg University Mainz (JGU), Dr. Libor Šmejkal, and Professor Tomas Jungwirth for their work establishing altermagnetism as a distinct form of magnetic order alongside ferromagnetism and antiferromagnetism.
“This award recognizes a fundamental discovery that challenged one of the most established paradigms in condensed matter physics,” said Professor Jairo Sinova, Director of the Spin Phenomena Interdisciplinary Center (SPICE) at Mainz University. “Discovering that an entirely new magnetic phase had remained hidden for more than one hundred years demonstrates that even the most mature scientific fields can still hold fundamental surprises.”
The breakthrough emerged from years of collaboration between Sinova’s research group at Mainz University and Jungwirth’s team at the Institute of Physics of the Czech Academy of Sciences in Prague. Šmejkal, who also maintained an affiliation in Prague, spent eight years at Mainz between 2016 and 2024, first pursuing doctoral research and later working as a postdoctoral scientist in Sinova’s group.
During that period, Šmejkal played a leading role in developing the theoretical framework behind altermagnetism. By combining advanced mathematical approaches to symmetry with spintronics, which studies how electron spin can be used in electronic devices, the researchers identified a previously unrecognized pattern of magnetic behavior.
Their predictions soon attracted experimental teams around the world. Measurements of electronic properties and electrical transport in multiple materials provided evidence supporting the new magnetic classification. Altermagnetism has since grown into one of the most active areas of condensed matter physics, with research efforts expanding across Europe, North America, and Asia.
A Third Form of Magnetism Rewrites Physics
For more than 100 years, physicists generally divided collinear magnets into two fundamental categories: ferromagnets and antiferromagnets.
Ferromagnets have an overall magnetic alignment that produces a net magnetization. These materials are essential to many magnetic memory technologies used today. In conventional antiferromagnets, opposing magnetic moments cancel one another, leaving no overall magnetization and producing electronic behavior very different from that of ferromagnets.
Altermagnetism introduces a surprising third possibility.
Like antiferromagnets, altermagnets have magnetic moments that cancel out, resulting in no net magnetization. However, their electrons can exhibit properties previously associated with ferromagnets.
This unusual combination allows altermagnets to support electrical currents with strongly polarized electron spins while also displaying extremely rapid magnetic dynamics. Those characteristics could make them valuable for a new generation of spintronic devices, potentially advancing the speed and capabilities of future information technologies.
The significance extends well beyond electronics. Altermagnetism represents a previously unrecognized symmetry class of matter and has revealed unexpected connections to several major areas of modern physics, including topological phenomena, unconventional superconductivity, and quantum materials with strong interactions between electrons.
How Scientists Discovered Altermagnetism
The path toward this discovery began with theoretical investigations into unusual ways that electricity moves through magnetic materials. Among the early advances was the prediction of the crystal anomalous Hall effect, a phenomenon involving electrical transport in certain crystal structures.
Initially, these unexpected behaviors might have appeared to be unusual features of individual materials. However, the researchers eventually recognized that they were connected by a broader principle involving symmetries of electron spins.
Rather than representing isolated exceptions to established magnetic behavior, these materials belonged to an entirely different magnetic category.
A major milestone came in 2022, when the team published a comprehensive symmetry classification of altermagnetism and identified hundreds of materials that could potentially exhibit it.
Experimental physicists subsequently tested these predictions using several complementary methods. These included angle-resolved photoemission spectroscopy (ARPES), which reveals how electrons behave inside materials, along with measurements of electrical transport.
The results confirmed altermagnetic behavior in several materials, helping establish the new classification experimentally.
Interest in the discovery has expanded rapidly. Hundreds of scientific papers have appeared within just a few years, and altermagnetism has become a prominent subject at international physics conferences. The growing research community is now investigating both its fundamental properties and its potential technological applications.
The Europhysics Prize recognizes major advances in condensed matter physics, a field concerned with the physical properties and behavior of materials. Established in 1975, the award honors discoveries that have significantly advanced scientific understanding, with a substantial share of the recognized research conducted in Europe.
The 2026 prize recognizes the theoretical and experimental advances that established altermagnetism as a new fundamental form of collinear magnetic order.
The award ceremony was scheduled for September 2026 at the 32nd General Conference of the European Physical Society Condensed Matter Division (CMD32) in Graz, Austria.
The Scientists Behind the Breakthrough
Professor Jairo Sinova is a physics professor at Johannes Gutenberg University Mainz in Germany and director of the university’s Spin Phenomena Interdisciplinary Center. His research investigates magnetism, spintronics, and quantum materials.
Dr. Libor Šmejkal conducted much of the crucial theoretical work that led to the identification of altermagnetism while working at Mainz University from 2016 to 2024. His current affiliations include the Max Planck Institute for the Physics of Complex Systems, the Max Planck Institute for Chemical Physics of Solids, and the Institute of Physics of the Czech Academy of Sciences.
Professor Tomas Jungwirth is affiliated with the Institute of Physics of the Czech Academy of Sciences and the University of Nottingham. He has collaborated extensively with Sinova’s Mainz research team and played a central role in establishing the theoretical foundations of altermagnetism.
Together, their work has revealed a fundamental property of magnetic matter that escaped recognition for more than a century, opening an entirely new direction for research into quantum physics and future electronic technologies.
Lena Dunham has confirmed that she’s currently working on five brand new episodes of the award-winning 2010s series, bringing Allison Williams, Jemima Kirke, Zosia Mamet and Andrew Rannells along for the ride, with production getting underway in the summer of 2027.
“We always said we would only return to Girls if there was a specific story we were burning to tell,” Lena said in a statement. “I’ve missed these characters, but for a long time I couldn’t quite picture them in the present day.
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“Then, right around my 40th birthday [in May 2026], they started talking to me in the shower. And, as you may remember, once this fivesome starts talking it’s pretty hard to get them to stop.”
The cast of Girls pictured in the show’s penultimate episode
Naturally, all this nostalgia for Girls has got fans speculating about where the characters will be a decade on from when we last saw them. But it’s also had us reflecting on what the series’ stellar cast have been up to in the last 10 years, too…
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Lena Dunham
Megan Stalter and Lena Dunham in the Netflix rom-com Too Much
Girls catapulted Lena Dunham to international fame as the show’s lead actor, creator, writer and director.
Since the show’s final episode in 2017, her on-screen work has included playing the radical feminist Valerie Solanas in American Horror Story and Catherine “Gypsy” Share, a member of Charles Manson’s cult, in the film Once Upon A Time In Hollywood.
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As for her behind-the-scenes work, Lena has directed the movies Catherine Called Birdy and Sharp Stick, as well as the first ever episode of the British financial drama Industry.
In 2025, she also helmed the romantic comedy series Too Much for Netflix, in which she played a supporting character, alongside Megan Stalter and Will Sharpe as the the series’ leads.
The year that Girls came to an end, Allison played a key role in Jordan Peele’s game-changing and Oscar-winning horror movie Get Out, portraying Daniel Kaluuya’s on-screen girlfriend whose parents have a sinister secret.
You may have also seen her in series like The Mindy Project, Netflix’s reimagining of A Series Of Unfortunate Events and the romantic drama Fellow Travellers, playing the childhood friend of Matt Bomer’s Hawk.
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Jemima Kirke
Jemima Kirke as Hope Haddon in Sex Education
Jemima Kirke has been involved in an eclectic mix of projects since the Girls finale.
In addition to all of that, she has made a one-off appearance in Law & Order: Special Victims Unit, played Zayn Malik’s love interest in his Dusk Till Dawn music video and shared the screen with Jamie Dornan in the romantic drama Untogether.
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We also have to take a moment to celebrate Jemima as the meme queen that she is, inspiring not onebut two of our go-to reaction posts.
Zosia Mamet
Zosia Mamet in The Flight Attendant
Jennifer Rose Clasen/HBO
Since saying goodbye to Shoshanna, Zosia Mamet has continued to work on both the big and small screen.
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Already known thanks to her work in Mad Men, she later landed major roles in series like Unbreakable Kimmy Schmidt, Tales Of The City and Dickinson, in which she played Little Women author Louisa May Alcott.
Zosia and her co-stars in The Flight Attendant were nominated for a SAG Award for their performance in season one, and just this year, she played Nina Adler in Girls, which has already been compared favourably to Girls.
It’s fair to say Adam Driver‘s career has gone from strength to strength since Girls’ run.
Having already landed the role of Kylo Ren in Star Wars while the show was still on the air, he’s now a two-time Oscar nominee thanks to his work in the movies BlacKkKlansman and Marriage Story.
Adam went on to play Lady Gaga’s on-screen husband in House Of Gucci, Enzo Ferrari in Ferrari and the lead in Francis Ford Coppola’s ill-fated opus Megalopolis.
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Up next, he’s set to make his long-awaited MCU debut as the villainous Mister Sinister in the upcoming X-Men reboot.
Christopher Abbott
Christopher Abbott in Netflix’s East Of Eden
Shortly after Girls’ finale, Christopher Abbott landed roles in First Man, Vox Lux and Black Bear, which is where he met his future partner, Aubrey Plaza, with whom he now has a daughter.
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His other stand-out film work includes Poor Things, Kraven The Hunter, Wolf Man and The Testament Of Ann Lee, as well as the Apple TV+ drama The Crowded Room, which also featured Tom Holland and Amanda Seyfried.
Andrew Rannells
Andrew Rannells in the Great American Baking Show tent
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Already a Tony nominee by the time Girls came along, Andrew Rannells has continued his career in musical theatre, originating the role of Jim Bakker in the London production of Tammy Faye, as well as starring in a revival of The Boys In The Band on Broadway.
He has also racked up a string of impressive TV credits, voicing Matthew in the teen comedy Big Mouth, portraying Blair Pfaff in Black Monday, Kevin in Girls5Eva and Bradford Barton in Welcome to Chippendales.
Besides that, he’s popped up in the Will & Grace reboot, The Boys and Too Much, which reunited him with Lena, while his film work has included A Simple Favor, Ryan Murphy’s The Prom and Miss You, Love You.
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Outside of his acting work, Andrew is also now a co-host on the American version of The Great British Bake Off, known as The Great American Baking Show.
Alex Karpovsky
Alex Karpovsky as Rabbi Big Noah in Nobody Wants This
ERIN SIMKIN/NETFLIX
Following his time as the straight-talking Ray in Girls, Alex Karpovsky took a total 180 when he landed a role in the psychological thriller Homecoming.
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He later appeared in Curb Your Enthusiasm and Angelyn, and can currently be seen as Big Noah in the Netflix rom-com Nobody Wants This.
Next year, Alex’s film Allow Me To Destroy You, which he both wrote and directed, is also slated for release.
Ebon Moss-Bachrach
Ebon Moss-Bachrach as The Thing in The Fantastic Four: First Steps
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Long before he was winning Emmys for his performance as Richie in The Bear, Ebon Moss-Bachrach was probably best known as Marnie’s on-off husband Desi in Girls.
From there, he was cast in The Punisher and The Dropout, before being cast in The Bear, for which he’s now won two Emmys.
In Girls, Jake Lacy played Fran, a short-lived boyfriend of Lena Dunham’s Hannah.
After that, he landed roles in I’m Dying Up Here, Fosse/Verdon, High Fidelity and Mrs America, before the series he’s now probably best known for, The White Lotus.
For his work in the inaugural series of the sun-soaked anthology series, Jake was nominated for an Emmy, and he’s also since starred in Furious and All Her Fault.
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Jon Glaser
Jon Glaser as Jeremy in the American version of Ghosts
During his stint as Hannah’s neighbour Laird in Girls, Jon Glaser was also starring as Leslie Nope’s nemesis, Jeremy Jamm, in Parks And Recreation.
He later landed his own mockumentary show, Jon Glaser Loves Gear, before more recent roles in Single Drunk Female, Life & Beth, the animated series Wylde Pak and the US remake of Ghosts.
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Over the last decade, Jon has also appeared in films like Wine Country, Hustlers and the Oscar-nominated Don’t Look Up.
Gaby Hoffman
Gaby Hoffman in C’Mon C’Mon
Besides her work as Adam’s chaotic sister Caroline in Girls, Gaby Hoffman is perhaps most well-known for her performance in Transparent, as Ali Pfefferman.
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Her subsequent TV roles have included the sports drama Winning Time, the Netflix drama Eric and Rian Johnson’s murder mystery Poker Face.
In 2021, Gaby played Joaquin Phoenix’s on-screen sister in the film C’Mon, C’Mon, and more recently starred opposite Josh O’Connor in The Mastermind and Jeremy Allen White in Deliver Me From Nowhere, appearing as the mum of Bruce Springsteen.
Riz Ahmed
Riz Ahmed in Sound Of Metal
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Towards the end of Girls’ run, Riz Ahmed made two pivotal appearances as Paul-Louis, the father of Hannah’s son Grover.
He was also nominated for an Oscar for his performance in the film Sound Of Metal, a year before winning in the Best Live Action Short category.
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Riz’s other more recent film roles have included the superhero drama Venom, the star-studded disaster movie Digger and the 2025 adaptation of Hamlet, in which he took on the iconic title role.
Richard E Grant
Richard E Grant pictured during his brief stint on The Celebrity Traitors
In the last decade, his profile has only continued to grow, notably landing his first Oscar nomination for his performance in 2018’s Can You Ever Forgive Me?, before joining the Star Wars universe as Allegiant General Pryde.
His 2020s film credits have included the musical Everybody’s Talking About Jamie, Emerald Fennell’s class satire Saltburn, the action comedy Argylle and the Jane Austen adaptation Persuasion.
If social media is anything to go by, autumn is a time for ‘spooky vibes’ and leaning into Halloween aesthetics. For some of us, though, it is about getting real bloody cosy.
This means walks in the park to enjoy the natural autumn hues of the outdoors before coming home, snuggling under a blanket and tuning into films and tvs with warm tones and autumn ‘vibes’.
If this sounds like your preferred autumn experience, we have just the shows and films for you…
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Set against the backdrop of fall in Boston, Massachusetts, Good Will Hunting is the story of mathematics genius Will Hunting and his experiences working as a janitor in MIT. It’s inspiring, emotional and has stellar performances from Matt Damon and Robin Williams.
Good Will Hunting is available on Prime Video, Paramount and Netflix UK.
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The crème de la crème of romcoms, When Harry Met Sally stars Meg Ryan and Billy Crystal as Harry Burns and Sally Albright as they find out whether men and women really can be “just friends”. It’s set in autumnal New York City and the fashion still inspires the best of autumn looks to this day.
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If you want cosy AND vintage vibes, You’ve Got Mail is the place to go. Written and directed by Nora Ephron who also wrote and directed When Harry Met Sally, You’ve Got Mail is a real enemies-to-lovers film and, yes, it’s fall in New York City. Delicious.
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You’ve Got Mail is available to stream on HBO Max.
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Wes Anderson’s adaptation of the Roald Dahl classic is gorgeous autumn vibes, especially if you are a fan of stop-motion animation. It’s a warm family adventure and one that you can enjoy with the kids, too.
The Fantastic Mr Fox is available to stream on Prime Video.
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If you are looking for a little more whimsical Wes Anderson fun, look no further than Moonrise Kingdom. This coming-of-age story is fun, cosy and sweet as anything.
Moonrise Kingdom is available to rent on Prime Video from £3.49.
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Oh captain, my captain! Dead Poet’s Society offers one of Robin Williams’ best performances. It’s a coming-of-age story set in Vermont and celebrates embracing the moment, being yourself and the love of arts.
Advertisement
Dead Poet’s Society is available to stream on Disney Plus.
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Following the lives of sisters Jo, Beth, Amy and Meg, Greta Gerwig’s adaptation of Little Women is the epitome of cosy. The film watches the sisters grow up in Massachusetts with stunning fall landscapes. Warning: you will very likely cry but you will still feel warm and fuzzy inside.
Little Women is available to stream on Netflix UK.
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Does it get more autumnal than Gilmore Girls? Probably not. It follows the lives of Lorelai Gilmore and her daughter Rory as they navigate life and love in the small town Stars Hollow. It is seemingly permanently autumn in this town and you know what? I’m not complaining.
Advertisement
Gilmore Girls is available to stream on Disney Plus.
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A coming-of-age TV show based in the UK, Heartstopper follows the lives of Nick and Charlie as they slowly fall in love and face teenage hardships together. Heartstopper is real queer joy and in terms of autumn vibes? Well, there are animated falling leaves that appear throughout the show.
Over The Garden Wall is a cosy, slightly (SLIGHTLY) spooky animated show following brothers Wirt, voiced by Elijah Wood and Greg, who get lost in a timeless forest and must find their way home.
Over The Garden Wall is available to stream on Paramount.
","type":"video","meta":{"author":"Rotten Tomatoes TV","author_url":"https://www.youtube.com/channel/UCz1GPotHecuLngiLuY739QQ","cache_age":86400,"description":"Check out the new Only Murders in the Building Season 1 Trailer starring Selena Gomez! Let us know what you think in the comments below.\n► Learn more about this show on Rotten Tomatoes: https://www.rottentomatoes.com/tv/only_murders_in_the_building/s01?cmp=RTTV_YouTube_Desc\n\nWant to be notified of all the latest TV shows? Subscribe to the channel and click the bell icon to stay up to date.\n\nUS Air Date: August 31, 2021\nStarring: Selena Gomez, Steve Martin, Martin Short\nNetwork: Hulu\nSynopsis: Only Murders in the Building is a comedy that surrounds three strangers who share an obsession with true crime and suddenly find themselves wrapped up in one. 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More of a cosy crime kind of person? Look no further than Only Murders in The Building. The show follows three kooky strangers who are obsessed with true crime and start a podcast together to solve a murder, yes you guessed it, in their building.
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The show has guest stars such as Paul Rudd, Meryl Streep and Kumail Nanjiani and some real hijinks fun.
Only Murders In The Building is available to stream on Disney Plus.
An experimental drug developed at Michigan Medicine has reversed a serious form of fatty liver disease in animal studies by targeting an unexpected source of liver damage: the gut.
The compound, known as DT-109, works by reducing harmful gut bacteria, protecting the intestinal lining, and preventing inflammatory substances from reaching the liver. According to findings published in The Journal of Clinical Investigation, this approach successfully reversed metabolic dysfunction-associated steatohepatitis (MASH) in animal models, offering a promising new strategy for treating a disease that remains difficult to manage.
MASH affects approximately 7% of the world’s population. It is a severe form of fatty liver disease in which excess fat accumulates in the liver, causing inflammation and cellular damage. Over time, the condition can progress to cirrhosis, which involves extensive liver scarring, as well as liver cancer and liver failure. Although treatment options have improved in recent years, effective therapies remain limited.
“We see clear evidence that DT-109 protects the gut epithelial barrier, reducing the systemic influx of harmful microbial products that are thought to contribute to MASH development and progression,” said Eugene Chen, M.D., Ph.D., senior author of the study and Frederick G. L. Huetwell Professor of Cardiovascular Medicine at the University of Michigan Medical School.
“This compound shows benefits to the gastrointestinal system and has great potential as a treatment for MASH.”
How Harmful Gut Bacteria Can Trigger Liver Damage
Chen’s research team had previously demonstrated that DT-109, a glycine-based tripeptide, could improve MASH in animal studies. A tripeptide is a small molecule made from three amino acids, which are the building blocks of proteins. What remained unclear was exactly how the compound produced its protective effects.
The latest research provides an explanation, revealing how changes in gut bacteria can set off a chain reaction that damages the liver and how DT-109 can interrupt that process.
Before examining the drug’s effects, the scientists confirmed an important contributor to MASH: excessive growth of Clostridium perfringens, a bacterium that produces ammonia inside the intestines.
When ammonia levels rise, they can damage the gut’s protective inner lining. Normally, this intestinal barrier helps prevent potentially harmful substances from escaping the digestive tract and entering the bloodstream.
As the barrier weakens, however, toxins and other products generated by gut microbes can travel to the liver. Once there, they can provoke inflammation and activate immune defenses in ways that worsen liver damage.
One response involves the excessive activation of CD8+ T cells, immune cells that normally help the body destroy infected or abnormal cells. When these cells become overactive, they can contribute to the inflammatory processes associated with MASH.
The findings help explain why a disease centered in the liver can be strongly influenced by events occurring elsewhere in the digestive system.
Experimental Drug Repairs the Gut and Protects the Liver
Through a series of experiments, researchers discovered that DT-109 disrupts this damaging cycle by improving the intestinal environment and reinforcing the gut’s protective barrier.
In both mice and nonhuman primates, the compound reduced levels of Clostridium perfringens and lowered ammonia production in the intestines. These changes helped strengthen the intestinal lining, limiting the movement of harmful microbial substances into the body and reducing their potential to damage the liver.
The results were particularly encouraging in nonhuman primates, whose liver biology and gut microbial communities more closely resemble those of humans than those of mice. In these animals, DT-109 reduced liver inflammation and lessened the severity of MASH.
Together, the findings show how targeting harmful processes in the gut can produce beneficial effects in the liver, even though the drug acts primarily within the gastrointestinal system.
“DT-109 connects microbiota modulation with liver protection by restoring gut barrier integrity and limiting the systemic translocation of ammonia and other pro-inflammatory microbial products within the gut-liver axis,” said Jifeng Zhang, Ph.D., co-author and research professor of cardiovascular medicine at U-M Medical School.
“We also found that DT-109 primarily acts in the gastrointestinal tract, but its reach stretches much further.”
The gut-liver axis refers to the close biological relationship between the digestive tract and the liver. Substances absorbed from the intestines travel to the liver through the bloodstream, making liver health particularly sensitive to changes in gut bacteria and intestinal barrier function.
By targeting this connection, DT-109 may offer a way to address some of the processes driving liver inflammation rather than focusing exclusively on damage that has already occurred.
Potential Benefits Beyond Fatty Liver Disease
Researchers believe the compound’s ability to protect the intestinal barrier could make it useful against other conditions involving inflammation and metabolic dysfunction.
Previous research has shown that DT-109 can reduce the formation of atherosclerotic plaques and prevent vascular calcification in nonhuman primates.
Atherosclerotic plaques are deposits of fat and other substances that accumulate inside artery walls, potentially restricting blood flow and increasing the risk of cardiovascular problems. Vascular calcification occurs when calcium builds up in blood vessel walls, making them less flexible and contributing to cardiovascular disease.
These findings suggest that DT-109 could eventually have applications in treating both liver and cardiovascular conditions, an important possibility because metabolic disorders often affect multiple organs.
The researchers are also interested in whether the compound could help people with inflammatory bowel disease (IBD), a group of chronic conditions that includes Crohn’s disease and ulcerative colitis.
Because problems with the intestinal barrier are associated with several gastrointestinal disorders, a treatment that strengthens this barrier might have benefits beyond protecting the liver. However, additional research will be needed to determine whether DT-109 is effective against these conditions.
A Promising Treatment That Still Needs Human Trials
Despite the encouraging results, DT-109 remains an experimental treatment. Its ability to reverse MASH has been demonstrated in animal models, but researchers have not yet established whether it can safely and effectively produce similar benefits in humans.
The next phase of research will involve further evaluation of the compound, with the goal of advancing it toward clinical trials. Those studies will be essential for determining its safety, appropriate use, and potential effectiveness in patients.
“This study presents novel evidence about the pathogenesis of MASH and provides excitement about a therapeutic avenue to explore for a condition that remains difficult to treat,” said Elliot Tapper, M.D., Academic Director of Hepatology at Michigan Medicine.
“What patients with MASH need is a safe and effective therapy capable of improving their liver and heart health – of course we are excited about these developments.”
The discovery highlights an important shift in how scientists are approaching fatty liver disease. By addressing harmful gut bacteria and restoring the intestinal barrier, researchers may be able to protect the liver through a treatment that acts primarily outside the organ itself.
If future human studies confirm the benefits seen in animals, DT-109 could offer a new therapeutic option for patients with severe fatty liver disease while potentially addressing cardiovascular complications as well.
Funding and Disclosures
Ying Zhao, Oren Rom, Jifeng Zhang, and Y. Eugene Chen are listed as inventors on a patent application (Tripeptides and treatment of metabolic, cardiovascular, and inflammatory disorders).
Chen is also an inventor of DT-109. The University of Michigan holds the patent for the compound and has licensed it to Diapin Therapeutics. Both Chen and the university have an ownership interest in Diapin, which supplied DT-109 for the research and is continuing its development.
The human study protocol, all amendments, and the informed consent form received approval from the Institutional Review Boards at the participating sites. These included the First Affiliated Hospital of Xi’an Jiaotong University (approval number: XJTU1AF2023LSK330), the Institutional Review Board of Jinan University (approval number: 2016-017), and the University of Hong Kong/Hospital Authority Hong Kong West Cluster (approval number: UW 20-700).
All experimental procedures involving nonhuman primates were approved by the Laboratory Animal Care Committee of Xi’an Jiaotong University (approval number: 20191278) and the Institutional Animal Care and Use Committee of Spring Biological Technology Development Co., Ltd. (approval number: 201901). The study was conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.