Maisie Williams Unveils Major Hair Transformation After Shaving Head

The Game Of Thrones star has undergone a major hair transformation, debuting her new look on Instagram.

Maisie is now sporting a close buzzcut after shearing off her long locks.

The Ayra Stark actor has been slowly cutting her hair shorter over the last few months, revealing the result of her latest trip to the hairdressers on over the weekend, appearing to be on holiday.

Sharing a snap of her new ’do, Maisie said she was now “washing [her] head with facewash”, adding the hashtag #3in1girlie” on her post.

It is unclear if Maisie’s new look is for an upcoming film role.

She can currently be seen in new biographical drama Pistol – airing on Disney+ in the UK – which follows Sex Pistols guitarist Steve Jones and the band’s rise to prominence.

Maisie has recently been filming new AppleTV+ series The New Look, which charts the rise of fashion designer Christian Dior against the backdrop of World War II Nazi occupation of Paris.

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Rishi Sunak’s Latest Plan To Punish Those Who ‘Vilify’ UK Is Being Completely Torn Apart

Rishi Sunak has unveiled another new policy as part of his bid to become the next prime minister, but it has almost definitely backfired already.

The former chancellor, who has fallen behind his rival Liz Truss in the polls, says he intends to widen the definition of extremism to include those who “vilify” the UK.

These people, including those who have an “extreme hatred of Britain” will then be referred to the government’s de-radicalisation Prevent programme, according to Sunak, although this is a voluntary scheme.

This could include law-abiding citizens who criticise Britain, but Sunak’s campaign claim it would not include government criticism and was not legally binding.

He said these proposals would “refocus” Prevent on Islamic extremism, rather than right-wing militants, claiming: “We must never let those who seek to undermine and destroy our way of life to succeed.”

Sources also told The Telegraph that Sunak believed extremists wanted to attack the UK’s existence, not just its values.

Sunak said: “There is no more important duty for a prime minister than keeping our country and our people safe. Whether redoubling our efforts to tackle Islamist extremism or rooting out those who are vocal in their hatred of our country, I will do whatever it takes to fulfil that duty.

“Britain is a beacon of freedom, tolerance and diversity.”

Unfortunately, not everyone seemed to agree that this new policy echoed that.

Some people thought it was indicative of how the campaign was actually going for him – he is 34 points behind Truss according to the latest YouGov poll of Tory Party members.

Others pointed out that the policy announcement overlooked some key elements of the Prevent programme itself:

Then there were the people who just feared the idea altogether.

And it wasn’t long until the jokes started to get out of hand…

Truss’ camp also criticised the announcement for being “thin”, adding: “Mostly it’s a restatement of government policy. The few new proposals are superficial and unfunded with a risk of letting serious terrorists slip through the net by creating arbitrary targets.”

It comes the day after Truss’ huge U-turn on her proposed policy to cut public sector pay for workers outside of London. She has since claimed that her campaign was “misrepresented” when she said that.

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How to Win Against Your Favorite Distractions

What can you do when you realize that you’ve been wasting a lot of time succumbing to distractions, like endless social media or consumption-based activities, and it’s making you feel empty, hollow, disappointed, or even ashamed of yourself? How can you reboot and get your life (and your character development) back on track?

A key here is to raise your awareness of how this behavior pattern is punishing you and what you’re missing out on. And that’s the truth – you’re missing out on tons that life has to offer when you stick with the low-hanging fruit of repetitive but unfulfilling actions.

One way I like to do this is to maintain a clear line of sight to goals that are compelling. The goals have to be a lot more fascinating and stimulating than the distractions, and my goals need to provide emotional endurance that won’t easily fade. Otherwise the distractions will win. Limp goals won’t work.

Keeping long-term goals in our awareness requires a lot of refreshing. For many people this means looking at our goals and thinking about them every day or even multiple times per day. That’s a good test to see if the goals remain interesting or compelling or if they only look good on paper but don’t actually motivate action consistently.

I like to engage with my goals every day, and I’m constantly tweaking, refactoring, and refreshing them to keep them aligned with strong and persistent motivation. When I feel a goal becoming too mental and not thrilling enough, I know it’s dying and that I won’t likely achieve it till I pull it back into the emotional space. This is where reframing skills are a godsend.

Then comes the realization that with enough action and persistence and learning from mistakes, those goals can actually be achieved. Those experiences can be had. Are they better than Facebooking and video games? If not then the goals are no good and ought to be changed because those services are competing for your attention these days.

The future will introduce even more compelling distraction invitations, so your future goals will need to be even more competitive with those other services. If your goals can’t even out-compete today’s offers, you’re really have no chance in the years ahead. So you’d better learn how to pull ahead – and stay ahead – of those distractions today.

For some this may seem disheartening. I actually see it as exciting though. Why is reality providing so much temptation? Is it to pull you away from your goals and make you feel like a loser? No! It’s to invite you to up your goal-setting game. Stop setting such bland and wimpy goals. Set goals that scare you, that will radically transform your life, that will sculpt your character beautifully. Leap into spaces that you’re never explored before.

Most importantly, your goals must be personal. You can’t just rip them off from other people and expect them to have much motivating power. My best goals feel like goals that no one would set but me because they fit me and my personality in such a unique way. If your goals are generic and other people could just as easily set them, they probably won’t motivate you consistently.

A good goal is like a personal mission. It’s for you and you alone. Even if a goal involves a team project, your contribution is uniquely personal. A good goal dives deep into your private space of personal meaning. It’s part of your story, not someone else’s.

So please please please dump those lame-ass goals that you could read anywhere else online, like the ones to lose weight, make a certain amount of money, etc. Video games provide way more compelling goals than those.

You can still do some of those distracting activities for variety if you truly value them. Rachelle and I love watching TV shows and movies together, and sometimes we play video games. But those are filler activities around other goals, and they do provide value in a way that doesn’t feel empty or hollow. I often find inspiration in fictional worlds. I probably wouldn’t even be doing what I’m doing today if not for Star Trek, for instance, since that inspired many of my lifestyle decisions. Watching certain shows together is a fun bonding experience for us too; we often discuss them afterwards, even pausing to discuss while we watch.

I don’t have Facebook, Instagram, Twitter, or many other social media accounts since I don’t feel those services add enough value to my life today. I did find it interesting to explore them, but not to the extent of having them pull me away from more interesting goals. I do have Netflix, Apple TV+, Audible, YouTube, and other accounts that I appreciate. This is guilt-free. This kind of engagement actually builds enthusiasm for other goals if done right.

A good question to ask is: Would I appreciate having this account for another year (or five)? If not, that’s a good reason to cancel it.

When you compare your goals to your distractions, do your goals rise above your distractions enough that you’re going to feel a sting if you don’t work on your goals for a month or so? Do your goals compel you to take action? Do you find it necessary to put off non-goal actions, so you can advance your goals?

It’s one thing to feel disappointed if you wasting some of your life spinning in circles, but that isn’t enough by itself. It’s vital to be aware of what specifically you’re sacrificing if you don’t invest in something more meaningful. With a vague feeling of disappointment, going back to the distractions will remain the go-to treatment.

With a more specific feeling of disappointment where you develop high awareness of the progress you could have made but didn’t, it will be harder to return to distractions and not work on your goals. You’ll see that you’re delaying experiences that matter to you. You’ll see that you’re holding your character back from what you could become. You’ll see more of the specifics that you’re missing.

Your challenge is to create a vision of how you want your life to be, and then keep evolving that vision to make it personal, meaningful, and incredibly compelling. Arnold Schwarzenegger used to put up pics of bodybuilders on his bedroom wall, so he’d stay connected to the vision of how he wanted his body to be. While other people inspired him, he evolved those socially inherited goals into his own personal vision that mattered to him, and he infused a lot of his own personality into his goals. When he tried to pursue goals that other people set for him, like while he was in the military in Austria, he failed miserably.

I really love setting and achieving interesting goals. It’s hard as hell sometimes, and there are occasional setbacks to deal with, but in the long run that just makes the journey more rewarding. I especially love the long-term character sculpting effects. Even for goals I didn’t achieve (or that took longer than I expected), I still appreciate the character gains. I love the creative challenge of figuring out what to do next with my life.

When your goals become compelling enough, distractions become boring by comparison. You can still engage with side hobbies and entertainment if you want – I definitely do – but let those pursuits serve the big picture of where you want to take your life and character. I love the added stimulation and inspiration that comes from a variety of input, but if I overdo that, I’m really going to feel the sting of not making progress on my goals. I’ll be very aware of what else I’m not experiencing.

You have a lot of power to sculpt your experience of life. You can let other people direct your experience, and that’s okay for a while, but the long-term invitation is to do your own conscious sculpting and directing. I really enjoy helping people with those efforts since it’s so rewarding to see people take charge of their lives and create the kinds of experiences they truly appreciate.

Mutual appreciation is what this game is all about. Consider that even those services that you denigrate as distractions were probably created by people who hoped you’d appreciate their efforts. What you call a distraction was someone else’s life’s work. I like this framing because it helps me see that when I’m ready to let go of a service that has run its course for me, I can let go with some appreciation and respect for the value it did provide. I can even thank those services for how they helped me discover what other kinds of experiences I really want to have.

So realize that your distractions are actually trying to help you. If your distractions are more compelling than your goals, look to your distractions for insights about how you could set goals that are more engaging and meaningful for you. Clarify what you don’t like about those distractions, and challenge yourself to design experiences that are better than what they offer. If you can’t beat what those services provide, then you know you have more to learn about how to consciously create better experiences. And then you can actually engage with those services on that basis. You can use them as learning tools and stepping stones to discover how to set better goals and to create better experiences.

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Pig organs partially revived hour after death

Study could transform access to organs for transplant by reversing some of the damage caused after death.

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England’s Lionesses Ask Liz Truss And Rishi Sunak To Let Every Girl Play Football At School

England’s victorious Euro 2022 player have demanded Liz Truss and Rishi Sunak commit to ensuring every young girl is able to play football at school.

In an open letter to both Tory leadership candidates, signed by all 23 members of the squad which beat Germany 2-1 after extra time in Sunday’s final, the Lionesses have called on the government “to make a huge difference”.

“On Sunday evening history was made. The dreams of 23 women came true. England became European Champions for the first time in history,” the players said.

“We are looking to the future. We want to create real change in this country and we are asking you, if you were to become Prime Minister on 5 September, to help us achieve that change.

“We want every young girl in the nation to be able to play football at school. Currently only 63% of girls can play football in PE lessons.”

The players also asked that all girls be given access to a minimum of two hours a week PE.

“Not only should we be offering football to all girls, we also need to invest in and support female PE teachers too. Their role is crucial and we need to give them the resources to provide girls’ football sessions,” they added.

Both Truss and Sunak have committed to hosting a reception for the victorious Lionesses at No.10 if they are chosen to be the next prime minister.

Unlike other successful sporting teams, the winning England squad will not be honoured with a visit to Downing Street this week.

Boris Johnson was at the funeral of Northern Ireland peace process architect Lord Trimble on Monday and is now on holiday until Sunday.

The England men’s cricket team were invited to Downing Street following their win in the Ashes in 2005, as were the men’s Rugby World Cup victors in 2003.

The women’s national rugby and cricket teams have also previously been honoured with receptions at No 10.

In addition to calling for the Lionesses to receive honours for their Euros win, Labour has urged the Government to capitalise on England’s success to ensure young girls who are now inspired to get playing can go on to become stars.

Lucy Powell, Labour’s shadow secretary of state for digital, culture, media and sport, accused the Tories of having a “terrible record of building on our sports stars’ success with a real and lasting legacy”.

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This is how highly resistant strains of fungi emerge

An international research team has deciphered the mechanism by which the fungus Cryptococcus neoformans is resistant to fungus-specific drugs. It is a yeast-like fungus that can infect humans. Specific drugs, named antifungals, are available for treatment, but they don’t always work — a phenomenon similar to antibiotic resistance. A team from Duke University in the USA and Ruhr-Universität Bochum (RUB) has used genetic, bioinformatic and microbiological techniques to decipher the mechanism underlying this resistance. They describe it in the journal Nature Microbiology, published online on 2 August 2022.

“The results are highly relevant for combating fungal infections in clinical practice, veterinary medicine and agriculture,” says Professor Ulrich Kück, Senior Professor in General and Molecular Botany at RUB. He cooperated for the project with the Bochum researcher Dr. Tim Dahlmann and the team headed by Professor Dr. Joe Heitman, who is currently based at Duke University in North Carolina and has been a visiting professor at RUB on several occasions.

Number of fungal infections on the rise

“In the western hemisphere, the number of people with a lowered immune defence is increasing, because life expectancies are rising rapidly and treatment with immunosuppressants after organ transplants is becoming more common,” explains Ulrich Kück. “This is associated with an increase in fungal infections.” Cryptococcus neoformans is one of the most significant human pathogenic fungi responsible for so-called cryptococcosis. It triggers acute infections in immunocompromised patients; and the mortality rate may be as high as 70 per cent. This is because fungal strains that are resistant to the drugs often evolve in hospitals, which makes treatment more difficult. So far, it was unclear which cellular and genetic mechanisms lead to this resistance.

So-called transposons, however, were known to play a role in the resistances. Transposons are jumping genes, i.e. DNA segments that can change their position in the genome and thus affect the function of genes. If a transposon jumps into a gene that’s critical for susceptibility to a drug, it’s possible for resistance to emerge. The mobility of the transposons is controlled by regulatory RNAs, so-called small interfering RNA, or siRNA for short.

RNA mechanism causes resistance

In their current study, the researchers discovered gene mutations in resistant isolates that led to siRNA control being switched off. By introducing an intact copy of the gene, it was possible to restore siRNA control; as a result, the researchers were able to prevent the transposons from jumping and shed light on the cause of resistance. Due to their small size, the gene segments that code for siRNAs are not easy to find in the genome. Tim Dahlmann managed to locate them with special bioinformatic analyses. By identifying the resistance mechanisms, it will be possible to use them for the treatment of mycoses in humans in the future.

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Materials provided by Ruhr-University Bochum. Original written by Julia Weiler. Note: Content may be edited for style and length.

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Mechanism of bacterial toxins in deadly attacks

Only one thousandth of a milligram of the bacterial botulinum toxin is necessary to kill a living organism. The toxin unfolds its lethal effect by preventing the release of neurotransmitters at the point where nerve cells attach to muscles, thereby paralyzing them. As simple as it may seem, this process is in fact a sophisticated and multi-staged procedure. No less complex and in fact very effective is the intoxication process of toxin complexes (Tc), virulence factors of many bacteria, including insect and human pathogens.

A bacterial syringe delivers a deadly enzyme

The mechanism of action of Tc toxins has only recently been uncovered to a greater extent by the work of Stefan Raunser’s team in structural biology at the MPI Dortmund. “Unraveling the structure of the Tc toxin subunits and their assembly by cryo electron microscopy (cryo-EM) enabled us to understand the key steps of toxin activation and membrane penetration,” says Raunser. The scientists showed that the subunits of the Tc toxin complex work together like a syringe: once the subunits are assembled, structural changes in the complex trigger the opening of a cocoon which contains a toxic enzyme, which is then secreted in a unique injection mechanism via a channel into the host cell. There, it unfolds its deadly effect by disturbing the regulation of the cell’s cytoskeleton, which consists of a network of polymerized actin (F-actin) filaments involved in many essential cellular processes.

Setting up the opponent by reducing the striking distance

“For a long time, we struggled with obtaining a complete picture of the intoxication process, since we lacked the structural data of the secreted enzymes, one of which is TccC3,” reflects Raunser. Until recently, it was only known that TccC3 transfers an ADP-ribose group to actin promoting its aberrant polymerization, which leads to actin filament clumping. “TccC3 is what we call a “difficult” system for structural investigations due to its size and high flexibility,” says Hartmut Oschkinat. “Only by applying solution NMR, could we overcome this challenge and visualize the protein’s 3D structure for the first time.” By fusing two further cryo-EM snapshots of TccC3 bound to F-actin and of the modified F-actin alone, the scientists have uncovered the enzyme’s unique mechanism of action. “TccC3 acts like a boxer who sets up his opponent to make him vulnerable to the attack” says Stefan Raunser. In the first step, the enzyme binds to a region between two consecutive actin subunits of F-actin. TccC3 then opens a gate, which brings the molecule NAD+ that contains the ADP-ribose group within striking distance to a reactive site on actin. Once the bulky ADP-ribose group is transferred to F-actin, it is no longer accessible for its depolymerizing factors, whereby F-actin can no longer be broken down and thus clumps.

In addition to this discovery, the scientists’ findings have helped formulate an explanation for the strikingly high efficiency of the enzyme. When the enzyme detaches from F-actin, its gate mechanism prevents a futile rebinding to the already modified actin as preparation for the next attack. “It is amazing how all these mechanisms evolved to increase the toxins potency to the max. And nature did quite a good job since botulinum toxins, ricin and other biotoxins are still considered the most toxic substances known,” Raunser concludes.

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Materials provided by Max Planck Institute of Molecular Physiology. Note: Content may be edited for style and length.

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Stickers and a smartphone for easy nitrite detection on foods

Nitrates and nitrites give processed meats their characteristic pink color and robust flavor. Although many consumers want to limit consumption of these preservatives because the substances can form potentially cancer-causing compounds, knowing how much is in a food has been difficult to determine. Now, researchers reporting in ACS Applied Materials & Interfaces have developed a color-changing film that consumers can stick onto foods and easily analyze nitrite levels by snapping a picture with a smartphone.

Cured and processed meats, such as salami and bacon, are often treated with nitrite or nitrate salts to keep them looking and tasting fresh. Though nitrate is relatively stable, it can be converted to the more reactive nitrite ion in the body. When in the acidic environment of the stomach or under the high heat of a frying pan, nitrite can undergo a reaction to form nitrosamines, which have been linked to the development of various cancers. Some methods to determine nitrite levels in foods already exist, but they are not very consumer-friendly and often require expensive and laborious techniques and instruments. To help consumers make more informed decisions, Saúl Vallejos, José M. García and colleagues wanted to develop an easy-to-use nitrite quantification system.

To accomplish this, the researchers developed a film they called “POLYSEN,” which stands for “polymeric sensor,” made of four monomers and hydrochloric acid. Disks punched from the material were placed on meat samples for 15 minutes, allowing the monomer units and acid in the film to react with nitrite in a four-step azo coupling reaction. The disks were then removed and dipped in a sodium hydroxide solution for one minute to develop the color. When nitrite was present, the film’s yellowish hue deepened with higher nitrite levels in the food. To quantitate the color change, the researchers created a smartphone app that self-calibrates when a chart of reference disks is photographed in the same image as the sample disks.

The team tested the film on meats they prepared and treated with nitrite, in addition to store-bought meats, and found that the POLYSEN-based method produced results similar to those obtained with a traditional and more complex nitrite detection method. In addition, POLYSEN complied with a European regulation for migration of substances from the film to the food. The researchers say the new approach could be a user-friendly and inexpensive way for consumers to determine nitrite levels in foods.

The authors acknowledge funding from La Caixa Foundation and the Spanish Agencia Estatal de Investigación. They also acknowledge the support and collaboration of the company Inforapps.

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Materials provided by American Chemical Society. Note: Content may be edited for style and length.

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Archie Battersbee: Parents take case to European Court of Human Rights

The 12-year-old’s life support was due to be withdrawn on Wednesday morning.

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Drug deaths: Record number of fatalities in Wales

A record number of drug misuse deaths are reported in Wales for 2021, with a 41% rise.

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