Trial of blood tests to spot Alzheimer’s sooner

The long-term hope is that more people will be able to access new treatments at an earlier stage.

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Pig kidney transplant patient leaves hospital

The procedure was hailed as a historic step as doctors tackle a widespread organ donor shortage.

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Rishi Sunak Squirms As Cab Driver Tells Him To Deploy The Navy To ‘Stop The Boats’

Rishi Sunak said it was “not practical” to deploy the navy to the English Channel to deter migrant crossings as he was confronted by an angry voter.

The prime minister was faced with a question about tackling illegal migration from cab driver Grant Davis as he appeared on The Sun’s Never Mind The Ballots programme.

The Rwanda deportation plan, which is set to cost tens of millions of pounds, is key to Sunak’s pledge to “stop the boats” bringing unauthorised migrants to the UK.

Davis, who is part of The Sun’s “cabinet” as “transport secretary”, told Sunak to be more direct: “Why can’t you put the navy in the Channel so when the dinghies come over, you pull up, tow them back to Calais and say no thank you.

“If you want to send a message to the organised gangs bringing people over, that’s how you do it.”

Another member of The Sun’s “cabinet”, ex-Army captain Hugh Andree, said sending in the military would breach of France’s sovereignty.

Britain and Rwanda signed a deal almost two years ago that would see migrants who cross the English Channel in small boats sent to the East African country, where they would remain permanently. So far, no migrant has been sent to Rwanda under the agreement.

Elsewhere on the show, Sunak gave his strongest signal yet that he is willing to remove the UK from the European Convention on Human Rights amid the stalemate over the Rwanda policy.

The PM told The Sun that controlling immigration is more important than “membership of a foreign court”.

Critics have said the UK would be an international outlier along with Russia and Belarus if it left the convention, which is overseen by a court sitting in Strasbourg. The court’s president suggested in January the plan would breach international law.

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Are universities connected to local sustainability? A new study suggests yes…and no.

A new study finds that universities scoring strongly on measures of sustainability are associated with innovation and economic growth in their surrounding communities. However, the study did not find similar connections between university sustainability performance and environmental sustainability in their home communities.

“Society is facing a slew of global challenges, and we wanted to assess the extent to which higher education is contributing to the sort of transformative change needed to address these challenges,” says Christopher Galik, co-author of the study and a professor of public administration at North Carolina State University. “For this study, we started at the local level, exploring whether there was any association between university sustainability performance and sustainability in their surrounding communities.”

To explore the issue, researchers looked at data from 105 metropolitan areas in the United States, which are collectively home to 427 higher education institutions. Specifically, the researchers drew on data from two sources, the U.S. Cities Sustainable Development Goal (SDG) Index and the QS Sustainability Universities Ranking.

The SDG Index aggregates dozens of metrics related to a municipality’s sustainability efforts, covering issues such as climate action, energy efficiency and water use. The QS Sustainability Universities Ranking evaluates university efforts related to environmental sustainability as well as efforts aimed at addressing social concerns, such as global partnerships, community engagement and the health and well-being of students, faculty and staff.

The researchers wanted to see whether there was any relationship between universities that scored well on the QS Sustainability Universities Ranking and the municipalities that scored well on the SDGs.

“Sustainability is complicated — it has lots of different components,” says Ha Vien, first author of the paper and a Ph.D. student at North Carolina State University. “And we found that universities are associated with progress on some of those measures, but not others.”

The good news is that there was a very strong correlation between universities that score well on sustainability and communities that score well on innovation, reducing poverty, creating economic opportunities and reducing inequality.

“The bad news is that universities that perform strongly on sustainability measures are also associated with a decline in responsible consumption and production — measured here as increased air pollution and release of toxic chemicals — in their surrounding areas,” Vien says. “There was also little or no correlation between universities that scored well on environmental sustainability and the environmental sustainability scores of their communities.”

“This is an observational study, so it’s impossible to determine causation,” Galik says. “However, the evidence suggests two things. First, universities continue to be strongly associated with innovation and economic development. But second, the idea that universities can contribute to broader sustainable transformations doesn’t seem to be realized yet, at least on a large scale.”

“It took significant time and effort for universities to become the economic drivers that we see today,” Vien says. “Looking into the future, climate change will continue to be a defining challenge for the foreseeable future. Our findings highlight that there are still a lot of opportunities for higher education to make more of a difference in surrounding communities.”

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Intelligent liquid

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a programmable metafluid with tunable springiness, optical properties, viscosity and even the ability to transition between a Newtonian and non-Newtonian fluid.

The first-of-its-kind metafluid uses a suspension of small, elastomer spheres — between 50 to 500 microns — that buckle under pressure, radically changing the characteristics of the fluid. The metafluid could be used in everything from hydraulic actuators to program robots, to intelligent shock absorbers that can dissipate energy depending on the intensity of the impact, to optical devices that can transition from clear to opaque.

The research is published in Nature.

“We are just scratching the surface of what is possible with this new class of fluid,” said Adel Djellouli, a Research Associate in Materials Science and Mechanical Engineering at SEAS and first author of the paper. “With this one platform, you could do so many different things in so many different fields.”

Metamaterials — artificially engineered materials whose properties are determined by their structure rather than composition — have been widely used in a range of applications for years. But most of the materials — such as the metalenses pioneered in the lab of Federico Capasso, Robert L. Wallace Professor of Applied Physics and Vinton Hayes Senior Research Fellow in Electrical Engineering at SEAS — are solid.

“Unlike solid metamaterials, metafluids have the unique ability to flow and adapt to the shape of their container,” said Katia Bertoldi, William and Ami Kuan Danoff Professor of Applied Mechanics at SEAS and senior author of the paper. “Our goal was to create a metafluid that not only possesses these remarkable attributes but also provides a platform for programmable viscosity, compressibility and optical properties.”

Using a highly scalable fabrication technique developed in the lab of David A. Weitz, Mallinckrodt Professor of Physics and of Applied Physics at SEAS, the research team produced hundreds of thousands of these highly-deformable spherical capsules filled with air and suspended them in silicon oil. When the pressure inside the liquid increases, the capsules collapse, forming a lens-like half sphere. When that pressure is removed, the capsules pop back into their spherical shape.

That transition changes many of the liquid’s properties, including its viscosity and opacity. Those properties can be tuned by changing the number, thickness and size of the capsules in the liquid.

The researchers demonstrated the programmability of the liquid by loading the metafluid into a hydraulic robotic gripper and having the gripper pick up a glass bottle, an egg and a blueberry. In a traditional hydraulic system powered by simple air or water, the robot would need some kind of sensing or external control to be able to adjust its grip and pick up all three objects without crushing them.

But with the metafluid, no sensing is needed. The liquid itself responds to different pressures, changing its compliance to adjust the force of the gripper to be able to pick up a heavy bottle, a delicate egg and a small blueberry, with no additional programming.

“We show that we can use this fluid to endow intelligence into a simple robot,” said Djellouli.

The team also demonstrated a fluidic logic gate that can be reprogrammed by changing the metafluid.

The metafluid also changes its optical properties when exposed to changing pressures.

When the capsules are round, they scatter light, making the liquid opaque, much like air bubbles make aerated water appear white. But when pressure is applied and the capsules collapse, they act like microlenses, focusing light and making the liquid transparent. These optical properties could be used for a range of applications, such as e-inks that change color based on pressure.

The researchers also showed that when the capsules are spherical, the metafluid behaves like a Newtonian fluid, meaning its viscosity only changes in response to temperature. However, when the capsules are collapsed, the suspension transforms into a non-Newtonian fluid, meaning that its viscosity will change in response to shear force — the greater the shear force, the more fluid it becomes. This is the first metafluid that has been shown to transition between Newtonian and non-Newtonian states.

Next, the researchers aim to explore the acoustic and thermodynamic properties of the metafluid.

“The application space for these scalable, easy-to-produce metafluids is huge,” said Bertoldi.

Harvard’s Office of Technology Development has protected the intellectual property associated with this research and is exploring commercialization opportunities.

The research was supported in part by the NSF through the Harvard University Materials Research Science and Engineering Center grant number DMR-2011754.

It was co-authored by Bert Van Raemdonck, Yang Wang, Yi Yang, Anthony Caillaud, David Weitz, Shmuel Rubinstein and Benjamin Gorissen.

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Scientists further our understanding of how a foodborne bacterium can survive in food preparation environments

Scientists from the Quadram Institute and UK Health Security Agency have discovered that bacterial populations remain stable on factory floor despite cleaning efforts in ready-to-eat food production facilities.

In 2019, six people died from a listeria outbreak caused by contaminated ready-to-eat foods served in a number of hospitals across the UK. In light of this, scientists are now performing vital research which helps to understand how these pathogens can persist in ready-to-eat food preparation environments.

Listeria monocytogenes is a foodborne bacterium that causes an illness called listeriosis. Symptoms for healthy individuals include a high temperature, aches and pains, feeling or being sick; but infection in those who are pregnant, elderly or immunocompromised, can lead to death.

The safety of foods is therefore paramount within the food industry. However, even in the face of well-implemented strategies to disinfect facilities and control for microbial risks, microbes such as listeria can occasionally breach food safety barriers and cross-contaminate food products. This is particularly dangerous in ready-to-eat foods where consumers will not kill contaminating bacteria by heating the food before eating it. Despite this danger, very little research has been done to understand the bacteria in ready-to-eat food production environments.

Researchers wanted to understand the potential sources of cross contamination and the factors that contribute to the survival of L. monocytogenes in these environments,particularly the communities of other microbes that support and protect it.

They began by sampling the floor of a ready-to-eat food factory that had recurrently detected L. monocytogenes in specific non-food contact areas of the factory. They sampled different sites: a preparation area, where ingredients were kept at 4°C, and a production area where they assembled and packaged the food, kept at 10°C. They aimed to measure the changes of bacterial communities over time, so they sampled the sites over ten weeks, before and after cleaning. They then cultured and performed genetic analysis on the samples to identify which bacteria were present and in what proportions.

The results showed that the populations of bacteria that coexist with L. monocytogenes were stable over time and have adapted to the conditions on the factory floor, including food safety controls. Maria Diaz from the Quadram Institute and lead of the study explains, “as L. monocytogenes is supported by a stable community of other bacteria, we may now need to develop new strategies to alter the whole bacterial population to effectively eliminate the pathogen.”

While the overall bacterial populations, and proportions of bacteria were stable before and after cleaning, Maria explains that we cannot assume cleaning efforts do not work. “The populations are very stable, and cleaning is not shifting the composition — it’s not letting one bacterium grow over another. After cleaning, the bacteria reduce in numbers and the bacterial load is lower, making cross contamination less likely.”

There was a marked difference, however, between the different areas of the factory at different temperatures; suggesting that the bacterial populations are highly adapted to the different environments within the factory. It also suggests that the bacteria present in the factory are established populations rather than bacteria introduced from outside sources — as despite movement of personnel between them, the populations remained stable.

While the factory had listeria under control at the time of sampling, this new research is important for understanding the different communities of microbes in different environments across ready-to eat-food facilities. Researchers hope that understanding how listeria survives in these environments could inform more accurate laboratory testing of cleaning methods. Maria adds, “thanks to this research, we can better understand the lifestyle of this pathogen and start to develop laboratory models that allow us to investigate new ways of killing listeria.”

Maria Diaz will present her data at this year’s Microbiology Society Annual Conference which will take place at Edinburgh International Convention Centre. Her talk “Deciphering microbial dynamics in a Ready-to-Eat Food production facility: Insights into Listeria monocytogenes persistence” will take place on 11 April.

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One in five waiting for hospital care – survey

A new poll by the Office for National Statistics suggests waits in England are worse than feared.

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Katie Price low-calorie diet advert banned

The social media post irresponsibly promoted a diet that fell below 800 calories a day, a watchdog says.

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Gwyneth Paltrow Gives A 2-Word Answer On If She Would Try Polyamory

From becoming the spokesperson for the so-called benefits of vaginal steaming to concocting a viral vagina-scented candle, Gwyneth Paltrow hasn’t been one to shy away from branching out from the norm.

However, there’s one thing the Oscar-winning actor isn’t willing to delve into.

While hosting a Q&A session on her Instagram story last Friday, Gwyneth was asked by a fan if she would ever consider being in a polyamorous relationship, according to People.

“No thanks!” she wrote in response.

The Avengers star clarified that although she’s not a fan of the practice of having romantic relationships with more than one partner at the same time, she’s not side-eyeing anyone who wants to double up on spouses.

“Not for me but [I] have no judgment. I’m a one man kinda gal,” she said.

Gwyneth is married to TV writer Brad Falchuk. They tied the knot in 2018.

She is the stepmother to her husband’s two children, Isabella and Brody Falchuk, whom he shares with his ex-wife, Suzanne Bukinik.

Prior to Brad, Gwyneth was married to Coldplay singer Chris Martin, with whom she shares two children: Apple and Moses Martin.

In October of last year, Gwyneth gushed about her husband in an interview with Bustle.

“I love my husband so much, so that’s really shifted things for me,” she said when asked if she feels freed of the male gaze the older she’s gotten.

“I probably don’t walk into a room the way I used to walk into a room because of that.”

“I feel really lucky. He’s a great guy, and he’s my best friend,” the Shakespeare In Love star added.

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Sunak Tells Netanyahu He’s ‘Appalled’ By Killing Of Aid Workers In Gaza

UK prime minister Rishi Sunak has told Israeli leader Benjamin Netanyahu that he is “appalled” by the killing of aid workers in an Israeli strike in a sign of a growing split between the two allies.

The leaders spoke after it was confirmed three UK citizens were among seven workers for the World Central Kitchen food charity killed in Gaza.

Downing Street said Sunak “demanded a thorough and transparent independent investigation into what happened” and described the situation in Gaza as “increasingly intolerable”.

Britain is a staunch ally of Israeli, but Sunak has become increasingly critical of the conduct of the war. He is under pressure to suspend UK arms exports to Israel.

He told Netanyahu that “Israel’s rightful aim of defeating Hamas would not be achieved by allowing a humanitarian catastrophe in Gaza”.

The UN says at least 180 humanitarian workers have been killed in the war so far.

James Henderson, 33, and John Chapman, 57, were named as two of the Brits who had died in the bombing. On Tuesday night, a third was named as James Kirby by the BBC.

People inspect the site where World Central Kitchen workers were killed in Deir al-Balah, Gaza Strip.
People inspect the site where World Central Kitchen workers were killed in Deir al-Balah, Gaza Strip.

via Associated Press

A Downing Street spokesperson said: “The prime minister spoke to Israel’s prime minister Benjamin Netanyahu this evening.

“He said he was appalled by the killing of aid workers, including three British nationals, in an airstrike in Gaza yesterday and demanded a thorough and transparent independent investigation into what happened.

“The prime minister said far too many aid workers and ordinary civilians have lost their lives in Gaza and the situation is increasingly intolerable.”

Netanyahu has acknowledged that the country’s forces had carried out the “unintended strike” on “innocent people in the Gaza Strip”. He says officials are “checking this thoroughly” and “will do everything for this not to happen again”.

Footage showed the bodies, several wearing protective gear with the charity’s logo, at a hospital in the central Gaza town of Deir al-Balah. Those killed also included an Australian, a Polish national, an American-Canadian dual citizen and a Palestinian, according to hospital records.

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