Dogs can detect Parkinson’s years before symptoms—with 98% accuracy

People with Parkinson’s disease (PD) have an odour that can be reliably detected from skin swabs by trained dogs, a new study has shown.

The research, in collaboration with Medical Detection Dogs and the Universities of Bristol and Manchester, was published on July 15 in The Journal of Parkinson’s Disease.

Two dogs were trained by the charity, Medical Detection Dogs, to distinguish between sebum swabs from people with and without Parkinson’s disease.

In a double blind trial, they showed sensitivity of up to 80% and specificity of up to 98%.

Not only that, they detected it in samples from patients who also had other health conditions.

The dogs were trained over a number of weeks on over 200 odor samples from individuals that had tested positive for PD and control samples from people who did not have the disease. Samples were presented to the dogs on a stand system and the dogs were rewarded for correctly indicating a positive sample and for correctly ignoring a negative sample.

In the double-blind testing, meaning that only a computer knew where the correct samples were, each line was also presented in reverse order so that samples for which no decision was made were re-presented. Then any unsearched samples were collected together in new lines, until a decision had been made for all samples.

A definitive diagnostic test for Parkinson’s Disease (PD) remains elusive, so identification of potential biomarkers could help diagnosis and timely intervention.

Claire Guest, Medical Detection Dogs CEO and Chief Scientific Officer, says: “We are extremely proud to say that once again, dogs can very accurately detect disease.

“There is currently no early test for Parkinson’s disease and symptoms may start up to 20 years before they become visible and persistent leading to a confirmed diagnosis.

“Timely diagnosis is key as subsequent treatment could slow down the progression of the disease and reduce the intensity of symptoms.”

Nicola Rooney, Associate Professor at Bristol Veterinary School at the University of Bristol and lead author, says: “Identifying diagnostic biomarkers of PD, particularly those that may predict development or help diagnose disease earlier is the subject of much ongoing research. The dogs in this study achieved high sensitivity and specificity and showed there is an olfactory signature distinct to patients with the disease. Sensitivity levels of 70% and 80% are well above chance and I believe that dogs could help us to develop a quick non-invasive and cost-effective method to identify patients with Parkinson’s disease.”

Perdita Barran, Professor of Mass Spectrometry at The University of Manchester, said: “It’s wonderful to be part of this research inspired by Joy Milne and our Nose2Diagnose programme. This study adds to the growing body of evidence showing that simple, non-invasive skin swabs can be used to diagnose Parkinson’s disease, offering a faster and more accessible method for early detection.”

The two dogs in the study were Golden Retriever, Bumper and Black Labrador, Peanut.

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Can’t sleep, can’t focus, can’t thrive? ADHD and insomnia may be a vicious cycle

Insomnia could explain why adults with ADHD traits report having a lower quality of life, according to new research led by the University of Southampton and the Netherlands Institute of Neuroscience.

A study published on July 15 in BMJ Mental Health found that having higher ADHD traits was associated with a lower quality of life and that insomnia could be part of the reason why.

At least one in four people with attention deficit hyperactivity disorder (ADHD) report having a sleep disorder, with insomnia being the most common of these.

“Our findings show a link between ADHD traits, insomnia severity, and reduced life satisfaction,” says Dr Sarah L. Chellappa, Associate Professor in Psychology at the University of Southampton and senior author on the research paper.

“We know that sleep disruption can impact neurobehavioral and cognitive systems, including attention and emotional regulation. At the same time, sleep disruption may arise from ADHD-related impulsivity and hyperactivity, suggesting a reinforcing cycle between sleep disorders and ADHD.”

Researchers from the University of Southampton and the Netherlands Institute for Neuroscience (Prof Eus Van Someren) examined data from the Netherlands Sleep Registry, an online survey with more than ten thousand adult participants.

The team analysed responses from 1,364 participants who had answered questions about ADHD traits, sleep disturbances, circadian factors, depression, and quality of life.

They found ADHD traits were associated with worse depression, more severe insomnia, lower sleep quality, and a preference for going to bed and waking up later.

ADHD and insomnia severity both predicted a lower quality of life, with analysis suggesting insomnia was the potential link in this association.

“Adults with ADHD traits may be more likely to have low sleep quality, insomnia complaints, and low mood levels, all of which lead to reduced life satisfaction,” says Professor Samuele Cortese, a co-author on the paper, also from the University of Southampton.

“There needs to be more research to understand this complex interplay. By improving our understanding, we could uncover treatment options that improve the quality of life of people with ADHD. For instance, targeting insomnia complaints in individuals with higher ADHD traits, with Cognitive Behavioural Therapy for Insomnia or Sleep Restriction therapy may help improve their quality of life.”

The paper Associations of ADHD symptom severity, sleep/circadian factors, depression, and quality of life is published in BMJ Mental Health and is available online.

The research was supported by the Netherlands Organisation for Scientific Research and the European Research Council.

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This Blinking Trick Could Help You Fall Asleep In Just 60 Seconds

I struggle to get to sleep at the best of times, an issue the recent onslaught of heatwaves hasn’t helped.

All the ‘pink noise’, delayed bedtimes, and even electricity changes have helped somewhat. But I’m always on the lookout for new tips – especially those that involve minimal effort.

Luckily, TikToker Helena Kennedy shared one of those in a recent clip, in which she revealed tips from her psychiatrist that helped her to defeat insomnia.

One of them involved blinking for a solid minute. So, we thought we’d find out whether it works.

How can blinking help you get to sleep?

Kennedy claimed blinking fast for 60 seconds means your eyes “get tired and trick your brain into sleep mode”.

A 2013 study found that blinking gives your brain a temporary “reset”, while 2017 research suggests blinking is treated “like a tiny nap” by your brain. It can decrease time perception by as much as 50-70%, researchers found.

But does that mean blinking will serve as a fast pass to the land of nod?

Well, speaking to Bustle, Livvi DiCicco, a sleep science coach with Sleepopolis, said it might, mostly because it serves as a distraction, which can be helpful if you’re lying in bed awake for more than 30 minutes.

Additionally, the expert said it can help to mimic your body’s natural sleeping cues, which may help your brain to realise it’s time to switch off.

How else can I get to sleep?

Morning light is uniquely helpful for orienting your body clock, which some researchers suggest is more important than actual sleeping hours for feeling reset. Therefore, going on a morning walk may help to get your Circadian rhythm in order.

Some studies suggest there could be some serious benefits to “clock blocking”, or refusing to look at the time when you get up in the middle of the night (I also swear by this trick).

And in a previous interview, sleep expert Dr Nerina Ramlakhan from Oak Tree Mobility told me “there’s a form of insomnia… called ‘orthosomia’, a term for the obsession with getting a good night’s sleep”.

In other words, try not to panic too much about your kip; it might paradoxically hurt you more than it helps.

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Scholars just solved a 130-year literary mystery—and it all hinged on one word

A medieval literary puzzle which has stumped scholars including M.R. James for 130 years has finally been solved. Cambridge scholars now believe the Song of Wade, a long lost treasure of English culture, was a chivalric romance not a monster-filled epic. The discovery solves the most famous mystery in Chaucer’s writings and provides rare evidence of a medieval preacher referencing pop culture in a sermon.

The breakthrough, detailed on July 15 in The Review of English Studies, involved working out that the manuscript refers to ‘wolves’ not ‘elves’, as scholars previously assumed.

Dr James Wade and Dr Seb Falk, colleagues at Girton College, Cambridge, argue that the only surviving fragment of the Song of Wade, first discovered by M.R. James in Cambridge in 1896, has been “radically misunderstood” for the last 130 years.

“Changing elves to wolves makes a massive difference,” Seb Falk said. “It shifts this legend away from monsters and giants into the human battles of chivalric rivals.”

James Wade said: “It wasn’t clear why Chaucer mentioned Wade in the context of courtly intrigue. Our discovery makes much more sense of this.”

“Here we have a late-12th-century sermon deploying a meme from the hit romantic story of the day,” Seb Falk said. “This is very early evidence of a preacher weaving pop culture into a sermon to keep his audience hooked.”

“Many church leaders worried about the themes of chivalric romances – adultery, bloodshed, and other scandalous topics – so it’s surprising to see a preacher dropping such “adult content” into a sermon,”said James Wade.

For the first time, the researchers have identified the great late-medieval writer Alexander Neckam (1157-1217) as the most likely author of the Humiliamini sermon. The 800-year-old document is part of MS 255, a Peterhouse Cambridge collection of medieval sermons.

Discoveries made 130 years apart

In 1896, M. R. James was looking through Latin sermons from Peterhouse’s library in Cambridge when he was surprised to find passages written in English. He consulted another Cambridge scholar, Israel Gollancz, and together they announced that these were verses from a lost 12th-century romantic poem which they called the Song of Wade. M. R. James promised further comment but this never came.

Nearly 130 years passed with no new evidence coming to light. Several scholars have attempted to work out the meaning of the sermon’s Wade quotation and speculated on what the full legend might have been like.

“Lots of very smart people have torn their hair out over the spelling, punctuation, literal translation, meaning, and context of a few lines of text,” said James Wade.

James Wade and Seb Falk argue that three words have been misread by scholars, because of misleading errors made by a scribe who transcribed the sermon. Most problematically, the letters ‘y’ and ‘w’ became muddled. Correcting these and other errors transforms the translated text from:

‘Some are elves and some are adders; some are sprites that dwell by waters: there is no man, but Hildebrand only.’

to:

‘Thus they can say, with Wade: ‘Some are wolves and some are adders; some are sea-snakes that dwell by the water. There is no man at all but Hildebrand.’

Hildebrand was Wade’s supposed father. While some folk-legends and epics refer to Hildebrand as a giant, if the Wade legend was a chivalric romance, as this study argues, Hildebrand was probably understood to be a normal man.

Chaucer and Wade

The Song of Wade was hugely popular throughout the Middle Ages. For several centuries, its central character remained a major romance hero, among other famous knights such as Lancelot and Gawain. Chaucer twice evoked Wade in the middle of this period, in the late 1300s, but these references have baffled generations of Chaucer scholars.

At a crucial moment in Troilus and Criseyde, Pandarus tells the ‘tale of Wade’ to Criseyde after supper. Today’s study argues that the Wade legend served Pandarus because he not only needed to keep Criseyde around late, but also to stir her passions. By showing that Wade was a chivalric romance, Chaucer’s reference makes much more sense.

In ‘The Merchant’s Tale’, Chaucer’s main character, January, a 60-year-old knight, refers to Wade’s boat when arguing that it is better to marry young women than old. The fact that his audience would have understood the reference in the context of chivalric romance, rather than folk tales or epics, is significant, the researchers argue.

“This reveals a characteristically Chaucerian irony at the heart of his allusion to Wade’s boat,” said James Wade.

The sermon

To make sense of the fragment, the researchers gave more attention to the Humiliamini sermon in its entirety than scholars have previously.

“The sermon itself is really interesting,” said Seb Falk. “It’s a creative experiment at a critical moment when preachers were trying to make their sermons more accessible and captivating.”

“I once went to a wedding where the vicar, hoping to appeal to an audience who he figured didn’t often go to church, quoted the Black Eyed Peas’ song ‘Where is the Love?’ in an obvious attempt to seem cool. Our medieval preacher was trying something similar to grab attention and sound relevant.”

The sermon offers a lesson in humility, a central concern of medieval theologians, but does so in unusual ways. It focuses on a debased Adam and compares human behaviours to animal traits. It presents powerful men who become like wolves because they plunder what doesn’t belong to them. And it compares the actions of cunning, deceitful and rapacious people to those of adders or water-snakes.

“This sermon still resonates today,” James Wade says. “It warns that it’s us, humans, who pose the biggest threat, not monsters.”

The preacher brings in a second topical reference to underline this point, telling the story of a real-life knight and crusader named Hugh of Gournay, who switched sides four times between England and France. The story doesn’t appear in any other surviving source, but the way the preacher tells it, he must have known his listeners would recognise it.

“It’s a bold image,” said Seb Falk: “the repentant Hugh wrapping a noose around his neck and throwing himself on the mercy of the French king is a powerful and really fresh symbol of chivalric humility.”

The researchers noticed multiple similarities in the arguments and writing style of Alexander Neckam, leading them to believe that he probably wrote the sermon.

But whether Neckam himself or an acolyte, the author must have been familiar with Wade and confident that his intended audience would get the reference.

Seb Falk said: “This sermon demonstrates new scholarship, rhetorical sophistication, and inventiveness, and it has strategic aims. It’s the ideal vehicle for the Wade quotation which served an important purpose.”

Seb Falk is a scholar of medieval history and history of science. James Wade is a scholar of English literature from the Middle Ages forward. Both are Fellows at Girton College, Cambridge.

Extract from the new translation of the sermon referring to Wade:

‘Dear [brothers], as to the fact that he says, ‘humble yourselves’, etc. – it could be considered that humility which is against the mighty hand of God is of a particular kind. For there are three kinds of humility: the humility of guilt; the humility of punishment; and the humility of penance.

Now, by the humility of guilt our first parent [Adam] was so humbled that, although he was made master of the whole world before his sins and ruled over everything that was in the world, after his sin, on the other hand, he could not even defend himself from a worthless worm, that is, from a flea or louse. He who was similar to God before sin, was made dissimilar through sin; since ‘by this poison a rose is sometimes turned into spikenard.’

Thus Adam was, from a human, made as if he was non-human; not only Adam, but almost everyone becomes as if non-humans. Thus they can say, with Wade: ‘Some are wolves and some are adders; Some are sea-snakes that dwell by the water. There is no man at all but Hildebrand.’

Similarly, today some are wolves, such as powerful tyrants, who if they can justly take the things of those subject to them, take them; but if not, [do so] by any means. Some imitate serpents, of which there are three kinds. Others become lions, like the proud ones whom God opposes; enough has been said of pride in the art of preaching. Others are foxes, such as cunning detractors and flatterers who speak with a double heart, who have honey in their mouth but bile in their heart. Others are gluttons like pigs, of whom the prophet says ‘their throats are open graves’; and thus each is judged similarly. Indeed, this humility is bad and perverse.’

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Is there a healthy way to tan?

Chris and Xand van Tulleken weigh up the pros and cons of being in direct sunshine.

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Physician associates need new job title, says review

It also recommends PAs and AAs wear standardised clothing and badges to distinguish them from doctors.

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Why are measles cases rising in the UK?

What are the symptoms of measles and how dangerous is the disease?

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Netflix Finally Gave Fans A Huge Stranger Things Season 5 Update — Here’s What We Know

Great news for fans of Netflix’s smash hit Stranger Things; the streaming giant has officially shared the release date for the new series of the show, whose last new episode aired in 2022.

They have also shared a poster and much-anticipated “teaser” for the upcoming season.

Here’s everything we know so far:

When will Stranger Things Season 5 come out on Netflix in the UK?

The first four episodes of the season, which Netflix calls “Volume 1”, are set to come out on November 26, 2025.

This will be followed by Volume 2, or episodes 5-7, which launches on Christmas Day (December 25, 2025).

The Finale, or episode 8, will come out on New Year’s Eve (January 1 2026).

“Each volume releases at 5pm PT,” or 1am GMT winter time, Netflix adds.

What’s the new Stranger Things season 5 poster?

The streaming network has described it as a depiction of “one big, ominous threat in Vecna.”

It has been shared on the show’s Instagram with the words “one last adventure” at its top.

Who is in the Stranger Things season 5 cast?

Netflix has shared that the upcoming season’s cast will include:

When is Stranger Things Season 5 set?

It’s set in 1987, a year after season 4 was set.

What do we know about the plot of Stranger Things Season 5?

Netflix’s official synopsis reads: “Hawkins is scarred by the opening of the Rifts, and our heroes are united by a single goal: find and kill Vecna. But he has vanished – his whereabouts and plans unknown.”

“Complicating their mission, the government has placed the town under military quarantine and intensified its hunt for Eleven, forcing her back into hiding. As the anniversary of Will’s disappearance approaches, so does a heavy, familiar dread.

“The final battle is looming – and with it, a darkness more powerful and more deadly than anything they’ve faced before. To end this nightmare, they’ll need everyone – the full party – standing together, one last time.”

Where can I watch the Stranger Things Season 5 trailer?

The ominous video has been praised by fans on YouTube for showing the “vibe” of the upcoming season without giving too many spoilers or plot details away.

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Will Stranger Things Season 5 be the show’s last season?

Yes – Netflix called it their “fifth and final” season.

Here’s hoping the upcoming episodes give the beloved franchise a worthy send-off.

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