New perspectives for wound healing and the treatment of chronic diseases

Fibroblasts are specialised connective tissue cells that play a key role in wound healing and tissue regeneration. The recent scientific publication from the University of Leipzig Medical Center shows that fibroblasts respond differently depending on the organ and disease context. Their functions are shaped by their embryonic origin, tissue-specific signals, and pathological stimuli. These specialised cells are not only involved in tissue repair and remodelling, but also influence the immune system and the development of diseases such as cancer, fibrosis and chronic inflammatory conditions.

“Until now, our understanding of fibroblast diversity has been based primarily on studies in animal models. This new review is the first to compare and integrate extensive human studies that have used modern single-cell technologies. This approach makes it possible to combine findings from different human studies, creating a comprehensive picture of the various origins and functions of human fibroblasts,” says Professor Sandra Franz, lead author of the study from the University of Leipzig Medical Center.

This deeper understanding of cellular heterogeneity opens up new avenues for the development of targeted therapies. In the future, it may be possible to specifically address certain fibroblast subtypes — for example, to promote tissue repair or to inhibit pathological processes such as tumour growth. This is particularly significant for regenerative medicine and the treatment of chronic diseases.

The authors of the study — Dr Marta Torregrossa, Professor Jan C. Simon, and Professor Sandra Franz (all from the University of Leipzig Medical Center), together with Dr Yuval Rinkevich (Helmholtz Munich) — are conducting joint research as part of the ZellTWund project. Their aim is to further characterise regeneration-promoting fibroblast subtypes and their roles in health and disease — thereby paving the way for new therapeutic approaches. Translating these findings into clinical applications remains a key challenge for the coming years, the Leipzig researchers conclude.

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Wild spinach offers path to breed disease resistance into cultivated varieties

Several varieties of wild spinach that originated in Central Asia show resistance to a destructive soil-borne pathogen that beleaguers growers of spinach seed in the Pacific Northwest — a finding that can be used to breed hardier crops.

Researchers at Washington State University’s Mount Vernon Northwestern Washington Research & Extension Center demonstrated in a new paper that some strains of wild spinach are resistant to Fusarium wilt, a fungal disease that is a persistent problem for growers of commercial spinach seed, and they identified regions of the plants’ genome associated with that resistance.

The findings are important for seed growers in western Washington and Oregon, where a significant portion of the world’s spinach seed is grown and where the pathogen has long been a problem due to the acidic soils.

“We were very, very pleased we found some excellent resistance when we did the screening and then we followed up with the DNA sequencing and looking at where that resistance might be lying,” said Lindsey du Toit, a plant pathologist who has worked on fighting disease in seed crops for 25 years at WSU’s Mount Vernon NWREC.

Though the new paper, published this month in Scientific Reports, identified several varieties of wild spinach associated with resistance to Fusarium wilt, more study is needed to understand the genetic nature of the resistance. However, seed companies don’t have to wait to apply the findings — they can begin breeding hybrids with the wild spinach varieties that showed resistance.

“You don’t necessarily have to understand the mechanism of resistance in order to use it,” du Toit said. “This is a tool that’s available immediately to breeding programs.”

Spinach consumption has been growing dramatically around the world. In the U.S., the per-capita consumption of the vitamin-rich vegetable has more than doubled in the past 20 years, with a particularly strong market for baby leaf spinach.

Most of the domestic crop is grown in hot, dry regions such as California, Texas and Florida. But growing spinach seed requires a rare combination of seasonal conditions — long, dry summers that aren’t too hot. As a result, around a fifth of the world’s spinach seed is grown in the Pacific Northwest.

But those crops have little resistance to Fusarium wilt, which afflicts spinach by entering through the roots and blocking their ability to take up water. Seed growers have tried to manage this problem by rotating spinach crops on long timeline — a decade or more between plantings — and taking other measures to treat the soil with calcium carbonate to reduce the acidity.

Even so, the prospect of an expensive “wipeout” of an entire crop has remained a continual threat.

In the current study, du Toit and a former post-doctoral researcher in her lab, Sanjaya Gyawali, screened 68 varieties of wild spinach from the region where the plant originated — Uzbekistan and Tajikistan — and compared them to 16 cultivated varieties. Researchers from the University of Arkansas also participated in the study.

They found strong resistance to the pathogen in several wild varieties. They then identified the chromosomal locations associated with the most powerful resistance. Those locations — known as quantitative trait loci — can be used by breeders to introduce more resistance to Fusarium wilt into commercial lines using marker-assisted selection, a technique that uses DNA markers to select for desirable traits.

The work was funded in part by the Specialty Crop Research Initiative of the U.S. Department of Agriculture’s National Institute of Food and Agriculture. The project was also supported by WSU CAHNRS Hatch Projects, and the Alfred Christianson Endowment in Vegetable Seed Science.

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Hannah Waddingham Reveals How She’s Really Feeling About Ted Lasso’s Surprise Return

Hannah Waddingham has opened up about the return of Ted Lasso.

The British actor won an Emmy for her performance as Rebecca Welton in the Apple TV+ sports comedy, and later made no secret of her disappointment when it looked as though it would not be returning for a fourth season.

Eventually, earlier this year, it was confirmed that new episodes of Ted Lasso were in the works after all, two years after it last aired.

Speaking on Tuesday’s edition of Capital Breakfast, the former Game Of Thrones star admitted she had complicated feelings about the prospect of Ted Lasso coming back, as she and her co-stars initially thought they’d “mourned the loss”.

“We were all a bit like, ‘Oh’,” Hannah admitted. “We thought we’d mourned the loss, and now it’s rising from the dead.”

Hannah Waddingham as Rebecca Welton in the most recent season of Ted Lasso
Hannah Waddingham as Rebecca Welton in the most recent season of Ted Lasso

However, she added that the news was “amazing”, while letting slip that shooting is due to begin in July.

Putting the show’s continued popularity down to the writing, she enthused: “Our writers are literally Jedi Knights. They’re just incredible. And we’ve got, like, a full room of real feminist men. So, we’ve got all the fabulous women in there – but the men that are in there, I think you really see [that they are feminists[ in the scripts.

“You could easily have a show that was so male-dominated, because, you know, myself and Juno Temple are like the two main women in it. So, it could really be out of control – but you’d never feel that. It’s just so beautifully drawn.”

Ted Lasso star and creator Jason Sudeikis revealed in March that season four would centre around the titular character taking over a women’s football team.

Jason explained: “It’s daunting, because we told the story we wanted to tell. But there’s more there. And it is a neat group of people to work with, it’s a wonderful group of people, and characters to write around and for. It’s such a great group.”

Seasons one to three of Ted Lasso are now streaming on Apple TV+.

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Gwyneth Paltrow Sets The Record Straight On Where Her Friendship Stands With Meghan Markle

Gwyneth Paltrow is setting the record straight on her relationship with Meghan Markle.

Over the weekend, People magazine published an interview with Gwyneth about the constant comparisons she and the Duchess of Sussex continue to face since the latter launched both her new lifestyle site and Netflix show.

“I don’t like that, when people try to pit women against each other,” the Oscar-winning actor told the outlet.

She said that the two, who both live in Montecito, California, have what she described as “a text friendship so far”.

Gwyneth seems open to collaborating with Meghan, though, and said she’d be down to make an appearance on the second season of the royal’s show, With Love, Meghan.

“Sure! Why not? You never know,” she said. “I don’t bake that well, but I can always try.”

The Goop founder previously spoke to Vanity Fair about feeling defensive of Meghan, without actually knowing her well.

“I was raised to see other women as friends, not foes,” she said at the time. “I think there’s always more than enough to go around. Everybody deserves an attempt at everything that they want to try.”

She said that when “there’s noise about certain women in the culture, I do have, always, a strong instinct to stand up for them”.

To make sure the masses knew that the Sliding Doors star and duchess were indeed on each other’s side, the two put out a memorable moment on Instagram in March.

In the Q&A video, Gwyneth read out an an enquiry saying: “Are you comprehending the Meghan Markle beef that social media says you two have?”

“I genuinely do not understand this at all, whatsoever,” she responded, at which point camera panned to a surprise cameo from Meghan, who was seen grinning and shrugging her shoulders as she ate a piece of pie.

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‘We can’t stay silent over endometriosis struggle’

Roya Rasouli, 27, promised herself on her hospital bed to share her story and is urging others to also.

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The Lampard Inquiry: What has happened so far?

Eight months into England’s first public inquiry into mental health deaths, what have we learnt?

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Can AI therapists really be an alternative to human help?

With NHS mental health waitlists at record highs, are chatbots a possible solution?

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JD Vance Uses Biden’s Cancer Diagnosis To Criticize His Job As President

Vice President JD Vance responded on Monday to Joe Biden’s new cancer diagnosis by criticising the former president’s performance in the White House and furthering claims that those close to the Democrat hid his poor health from the public.

Speaking to reporters on Air Force 2, the vice president first wished for Biden to make “the right recovery,” saying the 82-year-old’s diagnosis “sounds pretty serious.”

Vance essentially ended his empathy there, accusing Biden of doing a bad job leading the country and pinning his capacity to serve as president on his poor health.

“I will say, whether the right time to have this conversation is now or at some point in the future, we really do need to be honest about whether the former president was capable of doing the job,” Vance said.

“You can separate the desire for him to have the right health outcome with a recognition that, whether it was doctors or whether there were staffers around the former president, I don’t think he was able to do a good job for the American people.”

“And that’s not politics. That’s not because I disagreed with him on policy,” he continued. “That’s because I don’t think that he was in good enough health.”

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.@VP JD Vance on former President Biden’s cancer diagnosis: \"We really do need to be honest about whether the former president was capable of doing the job…I don’t think that he was in good enough health. In some ways, I blame him less than I blame the people around him.\" pic.twitter.com/0DYOd2mu4G

— CSPAN (@cspan) May 19, 2025

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.@VP JD Vance on former President Biden’s cancer diagnosis: “We really do need to be honest about whether the former president was capable of doing the job…I don’t think that he was in good enough health. In some ways, I blame him less than I blame the people around him.” pic.twitter.com/0DYOd2mu4G

— CSPAN (@cspan) May 19, 2025

Biden was diagnosed on Friday with an aggressive form of prostate cancer, which his office said has metastasised to his bones. Doctors diagnosed him after finding a prostate nodule while looking into the former president’s urinary issues earlier this year.

The Democrat’s age and health came front and centre last year after his concerning presidential debate performance while seeking re-election. Biden eventually stepped down to allow Vice President Kamala Harris to run in his place with just months until the election. Harris lost to Donald Trump, leading many Democrats to blame Biden’s initial persistence for their party’s loss.

Biden recently faced renewed bipartisan concerns regarding his health amid the upcoming release of “Original Sin,” a book by CNN’s Jake Tapper and Axios’ Alex Thompson that claims Biden aides intentionally hid the extent of his physical and cognitive decline from the public.

The allegations have led Republicans like Donald Trump Jr. — and apparently Vance — to baselessly accuse Biden and those close to him of hiding his cancer while he was still president. Trump Jr. faced backlash earlier on Monday for spreading, without evidence, a conspiracy that Biden was likely diagnosed while in the White House and that his wife, Jill Biden, helped keep it from the public.

“In some ways I blame him less than I blame the people around him. And why didn’t the American people have a better sense of his health picture? Why didn’t the American people have more accurate information about what he was actually dealing with?” said Vance, who serves as vice president to the man whose cognitive health has repeatedly come into question due to the 78-year-old’s frequent and incoherent ramblings, his memory issues and his impulsivity with respect to major political decisions.

“This is serious stuff. This is the guy who carries around the nuclear football for the world’s largest nuclear arsenal,” Vance continued. “This is not child’s play, and we can pray for good health, but also recognise that if you’re not in good enough health to do the job, you shouldn’t be doing the job.”

Cancers that have spread to other parts of the body are normally difficult to treat — but because Biden’s cancer appears hormone-sensitive, according to his office, he may be able to treat it by depriving the tumors of hormones. Doctors have said that, while metastasised prostate cancer is incurable, men receiving such treatment can expect to live for an average of five more years.

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