Eight countries added to methanol poisoning warning list

Japan, Mexico and Peru are among the nations included in the updated Foreign Office guidance.

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Scientists discover how a high-fat keto diet could keep your brain young

Protecting your brain’s energy and keeping your mind sharp might start with what’s on your plate. Foods such as fish and seafood, meat, non-starchy vegetables, berries, nuts, seeds, eggs, and even full-fat dairy may play a key role in maintaining cognitive health.

Exploring the Power of the Ketogenic Diet

At the University of Missouri, researchers are exploring how these foods influence brain function. Their work focuses on a high-fat, low-carbohydrate eating plan known as the ketogenic diet. Early results suggest that this approach could not only support long-term brain health but also slow or even prevent cognitive decline, especially among individuals who face a higher genetic risk of developing Alzheimer’s disease.

Inside the Roy Blunt NextGen Precision Health building, Ai-Ling Lin, a professor in the School of Medicine, and doctoral student Kira Ivanich are examining how the ketogenic diet may benefit people with the APOE4 gene, which is the strongest known genetic risk factor for late-onset Alzheimer’s disease.

In their recent study using mice, Lin and Ivanich found that females with the APOE4 gene developed healthier gut bacteria and showed higher brain energy levels when following a ketogenic diet compared to those on a high-carbohydrate diet. Males did not show the same improvement, suggesting that gender may influence who benefits most from this dietary approach.

How the Brain Uses Fuel

The key lies in how the brain produces its energy.

“When we eat carbs, our brains convert the glucose into fuel for our brains, but those with the APOE4 gene — particularly females — struggle to convert the glucose into brain energy, and this can lead to cognitive decline down the road,” Ivanich said. “By switching to a keto diet, ketones are produced and used as an alternative fuel source. This may decrease the chance of developing Alzheimer’s by preserving the health of brain cells.”

These findings highlight the potential of “precision nutrition,” an approach that adapts diets and interventions to fit a person’s unique biology.

“Instead of expecting one solution to work for everyone, it might be better to consider a variety of factors, including someone’s genotype, gut microbiome, gender and age,” Lin said. “Since the symptoms of Alzheimer’s — which tend to be irreversible once they start — usually appear after age 65, the time to be thinking about preserving brain health is well before then, so hopefully our research can offer hope to many people through early interventions.”

Advancing Research Through Collaboration

Lin joined Mizzou in part for its collaborative environment and advanced imaging facilities located in the NextGen Precision Health building and at the University of Missouri Research Reactor.

“We can do a lot of things in-house here that at other places we would have to outsource,” Lin said. “This is team science. The impact we make will be much better when we work together than by ourselves.”

With cutting-edge imaging equipment and both research and clinical spaces under the same roof, the NextGen Precision Health building allows Mizzou to move quickly from preclinical models to human trials.

For Ivanich, that real-world impact is personal.

“When my grandmother got Alzheimer’s, that sparked my interest in this topic, so being able to make an impact to help people preserve their brain health is very rewarding,” she said. “With Mizzou being a leading research university and having a tight-knit community feel, I know I’m at the right place.”

“Ketogenic diet modulates gut microbiota-brain metabolite axis in a sex-and genotype-specific manner in APOE4 mice” was published in the Journal of Neurochemistry.

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Boris Johnson left Inquiry in a hurry – he’ll be pleased not to come back

School closures seemed the only option but lockdowns probably went “too far” , former PM tells Covid Inquiry.

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‘What Is There To Regret?’: Bob Vylan Frontman Reflects On Glastonbury Chant Backlash

The frontman of the punk rap duo Bob Vylan has insisted he stands by the chant he performed at this year’s Glastonbury that landed the group at the centre of backlash.

Over the summer, the band provided Glastonbury with one of the year’s most talked-about sets, where they made headlines after leading the crowd in chants of “free Palestine” and “death to the IDF”, referring to Israel’s army.

At the time, the pair faced condemnation from Glastonbury’s organisers, the BBC – who broadcast the set live on its iPlayer service – and even the prime minister Keir Starmer.

Local police also said shortly afterwards that they were opening a criminal investigation based on both Bob Vylan and Kneecap’s Glastonbury sets, though this has since been confirmed to have been dropped.

During his first in-depth interview since the controversy arose, Bobby Vylan maintained on The Louis Theroux Podcast that he has no regrets about anything that transpired.

“If I was to go on Glastonbury again tomorrow, yes I would do it again,” Bobby insisted. “I’d do it again tomorrow, twice on Sundays. I’m not regretful of it at all.”

He continued: “The subsequent backlash that I’ve faced – it’s minimal compared to what people in Palestine are going through.

“If that can be my contribution and if I can have my Palestinian friends and people that I meet from Palestine, that have had to flee, that have lost members in double digits of their family and they can say, ‘yo, your chant, I love it. Or it gave me a breath of fresh air or whatever’ – and I don’t want to overstate the importance of the chant. That’s not what I’m trying to do – but if I have their support, they’re the people that I’m doing it for. They’re the people that I’m being vocal for.

“[In that case], what is there to regret? Because I’ve upset some right-wing politician, or some right-wing media?”

The vocalist and guitarist went on to say he didn’t anticipate the backlash Bob Vylan’s set would go on to receive, particularly as in the moment, even members of the BBC team said it had gone well.

“It wasn’t like we came off stage, and everybody was [appalled],” he claimed. “It [was] just normal. We [came] off stage, [it was] normal. Nobody thought anything. Nobody.

“Even staff at the BBC were like ‘That was fantastic! We loved that!’.”

Bobby also had choice words for Damon Albarn of Blur, who previously called Bob Vylan’s chant “one of the most spectacular misfires I’ve seen in my life”, alleging the frontman was “goose-stepping in tennis gear”.

“There’s no space to be hyperbolic in that. Especially given what we were accused of,” Bobby responded. “Being accused of being anti-Semitic, it was disappointing. Because it lacked self-awareness, I think, his response.

“I just want to say that categorising it as a ‘spectacular misfire’ implies that somehow the politics of the band or our stance on Palestinian liberation is not thought out. And as a more senior, experienced, veteran artist – he’s been in this industry for a long time – I think that there were other ways that he could have handled that question being fielded to him.”

He added: “I take great issue with the phrase ‘goose-stepping’ being used because it’s only used around Nazi Germany. That’s it. And for him to use that language, I think is disgusting. I think his response was disgusting.”

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Shortly after Glastonbury, the members of Bob Vylan said in a joint statement: “We are not for the death of Jews, Arabs or any other race or group of people. We are for the dismantling of a violent military machine. A machine whose own soldiers were told to use ‘unnecessary lethal force’ against innocent civilians waiting for aid. A machine that has destroyed much of Gaza.”

“The government doesn’t want us to ask why they remain silent in the face of this atrocity. To ask why they aren’t doing more to stop the killing. To feed the starving. The more they talk about Bob Vylan, the less they spend answering for their criminal inaction.”

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