Waking up at 3am is a surprisingly common experience – and there are plenty of reasons why it might happen.
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“During a typical night’s sleep, we go through multiple 90-minute cycles that include different stages of sleep, from light to deep and REM sleep,” the doctor said.
“Around 3am, most people are transitioning between cycles, and the sleep tends to be lighter at this point.”
This transition makes us “more susceptible to waking”, suggested the pro, especially if there are external disturbances such as noise, light, temperature changes or even the urge to use the toilet.
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But if you find yourself waking up multiple times throughout the night to pee, including a 3am dash to the loo, did you know it could signal an issue with your breathing?
Why your nighttime toilet trip and breathing could be linked
Nocturia, or nocturnal urinary frequency, is an issue characterised by needing to wee more than once throughout the night.
It can be caused by a range of factors, one of which is obstructed breathing.
Per the Sleep Foundation, “OSA affects the hormones that control urine production, leading to more frequent urination”.
In a post shared on Instagram, dentist Dr Mark Burhenne (@askthedentist) explained the mechanisms of this further: “When your airway collapses during sleep, you keep trying to breathe against a closed airway. This creates massive negative pressure in your chest that stretches your heart muscle.
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“Your heart responds by releasing a hormone called ANP (atrial natriuretic peptide) that tells your kidneys to dump sodium and water.
“Normally during sleep, your brain releases ADH (antidiuretic hormone) that tells your kidneys to CONSERVE water – so you can sleep through the night without peeing. But ANP actively SUPPRESSES that protective ADH signal. So you’re not just making more urine – your body’s brake system gets shut off too.”
He concluded that this means your body is “both actively MAKING more urine” and “blocking the signal that would conserve water”.
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What to do about it
Dr Burhenne recommended tracking your nighttime pee breaks, as once a night might be normal, but two or more times “is a red flag”.
If you are waking up two or more times to pee, he urges you to consider: “Do I snore? Wake up exhausted? Have a small/recessed jaw, crowded teeth, or a history of retractive orthodontics?”
And if this is the case, he recommends speaking to a professional.
Sleep apnoea can be serious if it’s not diagnosed and treated, warns the NHS.
Treatment typically involves wearing a CPAP machine to improve your breathing while you sleep.
Alternatively, you might be offered a mandibular advancement device (a gum shield-esque device to hold your airways open when you sleep) or surgery to help your breathing.
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Exercising regularly, sleeping on your side, losing weight if you’re overweight and adopting good sleep hygiene habits might also help.
We aren’t sure exactly why the two appear to be linked, though, and it can be very hard to unpick whether it’s an early symptom of Alzheimer’s vs an actual cause of it.
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New research, however, has found that turning off a circadian (related to the sleep-wake cycle) protein in mice reduced their levels of tau protein, the accumulation of which in the brain is linked to dementia.
It also seemed to raise their nicotinamide adenine dinucleotide, or NAD+, levels, associated with increased protection against dementia.
Why might your body clock be linked to dementia?
In the experiment, published in the journal Nature Ageing, scientists genetically removed a circadian protein called REV-ERBα in two groups of mice.
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REV-ERBα, which helps to regulate our metabolic cycle and inflammation levels, also appears to control our NAD+ levels (the coenzyme we mentioned earlier, which seems to counteract the changes linked to dementia).
In one of the groups of mice, they deleted REV-ERBα proteins across their entire body.
In another group, the deletion only happened in astrocytes – star-shaped cells which make up a large part of the nervous system and help to support our brains.
For both groups of mice, the change led to increased NAD+ levels.
Speaking to WashU Medicine about a separate paper published in Nature Neuroscience, Dr Erik S. Musiek, who was involved in both studies, said: “There are 82 genes that have been associated with Alzheimer’s disease risk, and we found that the circadian rhythm is controlling the activity of about half of those.
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“Knowing that a lot of these Alzheimer’s genes are being regulated by the circadian rhythm gives us the opportunity to find ways to identify therapeutic treatments to manipulate them and prevent the progression of the disease.”
What might this mean?
In the Nature Ageing paper, the researchers ran further studies that involved a combination of both the genetic deletion of REV-ERBα and a promising new medicine. This appeared to increase NAD+ levels.
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The researchers suggest that inhibiting the protein may be more useful at certain stages of dementia, like early on when tau tangles are forming, than others.
“Our studies shed light on crucial neuroprotective mechanisms mediated by REV-ERBα in astrocytes and should help guide ongoing drug development efforts to target REV-ERBα function in AD and other neurodegenerative diseases,” the paper reads.
No wonder it feels like everyone, everywhere, is constantly exhausted.
But if we’re all so wiped out, how can we be expected to tell “normal” tiredness from more concerning fatigue?
Here, we asked Dr Suzanne Wylie, GP and medical adviser for IQdoctor, when to worry.
When should I see a doctor about fatigue?
Speaking to HuffPost UK, Dr Wylie explained that fatigue “is a very common complaint in general practice and, in most cases, is related to lifestyle factors such as lack of sleep, stress, or overwork”.
But sometimes, it can be linked to underlying health issues – and its persistence can be a red flag.
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“As a GP, I would suggest that you should start to worry about fatigue if it is persistent, lasting more than a few weeks, or if it is unexplained by your usual activities or recent events,” she said.
Aside from longer-lasting fatigue, exhaustion with other symptoms should be investigated, too.
“You should also seek medical advice if the tiredness is accompanied by other symptoms such as unintentional weight loss, night sweats, fevers, breathlessness, chest pain, persistent cough, or changes in bowel habit,” the GP said.
Meanwhile, fatigue linked to low mood, disrupted sleep, and a loss of interest in hobbies “may indicate depression or anxiety, which also warrants assessment”.
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She added, “Additionally, if you notice symptoms such as increased thirst or urination, palpitations, dizziness, or heavy menstrual bleeding, it could point towards conditions like diabetes, thyroid disease, or anaemia”.
Anything else?
Per the NHS, you should see your doctor if fatigue lasts longer than a few weeks, if it affects your day-to-day life, and/or if you’ve noticed other symptoms like unexplained weight loss or mood changes.
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And if your partner or someone else tells you you’ve been “making gasping, snorting or choking noises when you’re asleep,” visit your doctor as this could be a sign of sleep apnoea.
“In short,” Dr Wylie ended, “while occasional tiredness is normal, persistent or unexplained fatigue, especially when associated with other symptoms, should always prompt a review with your GP”.
And with the upcoming clock changes, some of us might feel even more tired than usual. Some research suggests that even though we technically “gain” an hour’s sleep, most of us don’t actually rest for an extra 60 minutes.
Instead, Harvard Health writes, we’re actually more likely to wake up in the middle of the night, get up earlier, and struggle to nod off in the first place.
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This makes the advice from Dr Deborah Lee, a sleep expert from Doctor Fox, more welcome.
Working alongside Comfybedss, the doctor shared five tips for waking up more refreshed in this exhausting period.
1) Exercise in the morning if you can
OK, Dr Lee admits, most of us don’t exactly crave an early morning gym session – especially in cold, dark winter.
But “research has shown that doing a 30-minute workout with a medium effort will help you wake up a lot quicker than if you weren’t to reduce sleepiness,” she wrote.
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It doesn’t have to be a HIIT session or anything intense: a walk will suffice, she said (plus, morning light is uniquely good at regulating our body clocks).
2) Protect your Circadian rhythm
Speaking of which, the doctor said keeping your Circadian rhythm (or body clock) regular is important in the winter months.
“A huge factor in this is routine, and ensuring you’re going to sleep at the same time each night and waking up at the same time each morning,” Dr Lee said.
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“It isn’t just your sleeping pattern that needs to be kept in routine, but your daily meals, your shower and bath routine and your technology ‘switch off’ time.”
Sadly, the sleep expert said, that includes weekends too – tough, “but if you push through, then it will make your Monday wake-up a lot easier!”
3) Use natural light or a SAD lamp to wake up in the morning
If waking up to an inky sky is getting you down, Dr Lee says you’re not alone.
“When your eyes see light in the morning, it gives signals to your brain that it’s time to wake up,” she wrote, which can be “really confusing for the mind”.
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The best option, she advised, is to “utilise natural light by opening the curtains and getting outside as soon as possible”.
But if that’s not possible, “Invest in a night lamp so that you can put it on first thing in the morning. Or, a [SAD] lamp.
“These lamps will wake you, so it won’t be such a shock to the eyes when there’s a big, bright light next to you.”
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4) Be picky about your breakfast
Though you might be tempted to grab some toast or a cereal bar in a rushed weekday morning, “but a breakfast that is rich in both carbohydrates and protein should make you feel more alert quickly,” the doctor said.
5) Wait before grabbing that cup of morning coffee
It’s natural to reach for caffeine on a groggy morning. But per the sleep expert, the best results actually happen when you wait.
“You shouldn’t be reaching for the caffeine until at least 45 minutes after you wake up, as this is when the caffeine will give you the biggest fix,” she stated.
So why do I have 14 unread texts at the moment, and how come the idea of dragging my weary bones to an after-work event has made me sob in the past?
I love my friends, but if I’m honest, I am too exhausted by life and its endless admin to make plans as much as I’d like to.
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This is not fair of me, and I feel awful about it, but it seems to be a common concern: a 2024 study found that less than half of us spend as much time as we’d like with our mates, which makes sense since we hang out under half the amount we used to 10 years ago.
And, per Dating.com, Google searches for “don’t have time for friends” have jumped +163% this month.
If you’re in the same boat, what should you do? Here’s what Dr Uma Darji, a family doctor, and Lee Thompson, co-founder of Flash Pack (a travel company that brings solo adventurers together), told us.
Feeling too tired for friends is, sadly, all too common
Ironically, you are not alone in feeling too fatigued to hang out.
Dr Darji admitted, “When you’re juggling work, family, and the daily chaos of adult life, friendship can start to feel like another item on your to-do list. I see this all the time in my patients, and honestly, I’ve felt it too.
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“The truth is that mental and emotional exhaustion don’t just make us tired, but they also make us withdraw. Although catching up with a friend should feel energising, it can feel overwhelming when your brain is in survival mode.”
Thompson, meanwhile, said that he spent much of his 30s neglecting his friendships for the sake of his business.
“By the time I hit my 40s, the impact hit me hard – I felt long stretches of loneliness because I hadn’t nurtured the friendships that really mattered,” he shared.
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Interestingly, both told me that some degree of letting go is crucial if you want to rebuild your friendships.
Dr Darji said you should try as hard as you can to release any guilt you might feel. “You’re not a bad friend for being tired. Adult friendships don’t have to look like they did in college,” she said.
“What matters most is staying emotionally connected, not necessarily seeing each other constantly.”
Thompson stated, “I’ve learned that friendship doesn’t need to be complicated.” He began lowering the expectations he had for himself and his friends, and has been much happier since.
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How can I maintain friendships when I’m exhausted?
Like Thompson, Dr Darji said remodelling your social expectations to fit your adult life is key.
“I suggest adjusting expectations. If you aren’t up for a long dinner, try to engage with a short voice note or quick meme exchange to keep the lines of communication and connection alive without draining you,” she stated.
“Try to combine social time with activities you already do, such as walking with a friend while kids play or catching up while shopping for groceries, calling a friend when driving.
“Be honest with your friends, you don’t have to pretend that you can do it all.”
Thompson makes an important point, though; once you have adjusted your expectations to fit what is possible for you, stick to your new rules.
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The business co-founder says he puts “one dinner in the diary every month with my closest friends, and we never cancel.
“It’s the most important meeting I have all month because it energises me, helps me feel seen, inspires me and gives me space to breathe outside work and family life.”
While it might sound exhausting, the two experts told me, the payoff is definitely worth it.
“Connecting with others is essential to our emotional well-being,” Dr Darji explained.
“A short interaction can refill our cups in ways that only rest can’t… always remember that.”
Thompson, meanwhile, called it a “small investment that pays off massively for your mental health and happiness”.
Turns out that while some of us have different “chronotypes,” or natural predispositions towards being either night owls or early birds, some research suggests we should all try to nod off before a certain point anyway.
“To age healthily, individuals should start sleeping before 1am, despite chronobiological preferences,” the 2024 paper read.
The cohort study, which looked at 88,000 UK Biobank participants who were aged between 43 and 74, monitored participants’ sleep for a week before monitoring their heart health status over an average of 5.7 years.
They found that those who fell asleep between 10-11pm seemed the least likely to develop heart issues in that time.
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What may be the best and worst sleep times for heart health?
Those who fell asleep between 11pm and midnight were 12% more likely to develop heart health and circulatory issues during the study.
For those who fell asleep after midnight, that rose to 25%. Those who kipped before 10pm had a 24% increased likelihood of developing heart health issues, too, though the number of people who had this earlier bedtime was small in the study.
And as we shared, 10-11pm seemed to be the bedtime linked to the lowest risk.
Women seemed to be more affected by the discrepancies than men, too.
This, however, was only an observational study. That means that the scientists couldn’t prove that differences in bedtime definitely caused the changes in heart health outcomes – it only showed an association, or link, between the two.
According to Harvard Health, “nontraditional sleep times may disrupt the body’s 24-hour internal clock, or circadian rhythm, which plays a key role in regulating physical functioning”.
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And Regina Giblin, a senior cardiac nurse at the British Heart Foundation (BHF) said, “This large study suggests that going to sleep between 10 and 11pm could be the sweet spot for most people to keep their heart healthy long-term.
“Getting enough sleep is important for our general wellbeing as well as our heart and circulatory health, and most adults should aim for seven to nine hours of sleep per night.”
But, both warn, this study can’t prove that bedtime itself is definitely the cause of heart issues.
“More research is needed into sleep timing and duration as a risk factor for heart and circulatory diseases,” Giblin said.
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Sleep is not the only factor that can impact heart health either, she added.
“It’s also important to look at your lifestyle… knowing your numbers such as blood pressure and cholesterol levels, maintaining a healthy weight and exercising regularly, cutting down on salt and alcohol intake, and eating a balanced diet can also help to keep your heart healthy.”
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As you will have noticed stepping out your door this morning – it is now bloody cold! The Autumnal equinox has come and gone and summer is well and truly over.
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I look forward to spending the next month simultaneously boiling and freezing at various points during the day. (Layering clothing is more complicated than you’d think.) For many of us, the colder weather also prompts a new bedding dilemma.
For some of us this means wondering if now is the time to swap our duvet for a heavier tog, or turning our mattresses over to let them breathe a bit as we enter central heating season.
As an American who has lived in the UK for nearly 20 years, it has taken me a very long time to get used to sleeping without a top sheet. (I tried again recently, and decided I think I actually hate it.)
I could never really get on with the idea of sleeping with a duvet in the warm, late summer months until I started using this duvet. Basically, it does what it says on the tin.
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There are two parts to the duvet – one layer for the warmer months that’s only 3.5 tog, and another for the cooler months that’s 7 tog. If you’re terrible at fast maths, that’s a total of 10.5 tog if you’re wanting the warmest option available. Together, the layers become one fluffy, warm, cloud of a duvet. And on their own, still delightful.
The layers simply snap together with the little poppers on the edges of the duvet. This week I swapped the 3.5 tog for the 7 tog, and it’s the perfect weight and warmth for these funny months where it’s still warm in the day, and then brisk in the evenings and early mornings.
I’m also a big fan of sleeping with the window open – what’s more pleasant than a cool room and snuggling under a warm duvet? – so this is ideal for me.
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The best mattress for hot sleepers
I usually find mattress shopping to be a stressful event. How do you choose without laying on a hundred different mattresses? How do you really know which ones are comfortable? How can you ever be sure?
This is where honest reviews come in handy, so when I say that I absolutely LOVE the Simba Hybrid Pro Mattress, I genuinely mean it.
This is the first mattress I’ve been able to decide on as a newly single person, and it felt like a very big deal. I got to choose the firmness and size that I wanted – and I have to say I feel like a genius for deciding on this one. I went for a King, and what I love about this mattress is that it has a breathable layer and I don’t feel like I’m being boiled alive by a hot hob when I’m sleeping (which some mattresses genuinely feel like).
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It’s hard to believe when you first pull a rolled-up mattress out of a box that it’s going to actually unfurl into something that’s both comfortable and also thick enough to support you in your slumber – but it truly is. Because of how my move into my flat happened, I only had a few hours of the mattress being out of the box before I slept on it, and it was absolutely fine. By the next night, it was heavenly.
I continually find the height of this mattress to be really impressive. It has several fancy layers that I can’t exactly pretend to explain or understand all that they do, but crucially I know I can take off the top layer to have it washed, and that there’s a breathable wool layer, as well.
Firmness wise, this is excellent. As an elder millennial who just turned 40 – and spends a lot of money on physiotherapy – I can confirm that this is neither too hard, nor too soft. It’s comfortable and sturdy for all manner of nocturnal activities, and it doesn’t leave you with new cricks in your neck or kinks in your back when you wake. Ideal.
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The combination of the Simba Hybrid 3-in-1 Duvet and Simba Hybrid Pro Mattress really have helped give me the most comfortable and supported sleep I’ve had in months. I can’t recommend either enough – particularly if you run hot overnight or like to have options when it comes to your duvet tog.
You might already know that sleep experts have preferred dinner times, because eating less than two to four hours before your bedtime can mess up your kip.
But speaking to HuffPost UK, sleep psychologist Dr Katherine Hall (who has paired with Comfybedss) shared that the type of food you eat matters, too.
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“If you can’t fall asleep or struggle to stay asleep,” she advised, your diet might be at least partly to blame.
Here are three foods she skips before bedtime:
1) Salty food
“Sodium-rich meals result in fluid retention and increased blood pressure, making it hard for the body to switch off completely after eating snacks like crisps or salted nuts,” Dr Hall told us.
A 2006 paper found that salt can lead to delayed bedtimes, increased awakenings in the middle of the night, and less satisfying sleep.
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That’s because, the sleep expert said, a salt overload leads to “superficial sleep, where the sleep isn’t very deep and can often involve disturbances like going to the toilet more”.
She recommends avoiding foods like gammon and bacon, as well as other salty snacks, before bed.
2) Acidic food
Though many associate these with heartburn, Dr Hall says not all acidic foods are created equal.
“If we take a deep dive into certain acidic foods, those struggling to sleep will want to avoid some more than others. Tyramine is an amino acid that is normally a great addition to anyone’s diet as it stimulates natural brain activity,” she said.
“Foods that are high in tyramine include tomatoes, aubergines, soy sauce, red wine and cheeses,” the psychiatrist shared.
3) Spicy food
“For anyone struggling to sleep, avoid spicy foods altogether,” Dr Hall said.
That’s because “Digesting the various spices and chillies you have in your curries or other hot dishes can severely disrupt our body’s ability to thermoregulate, which essentially means managing our temperature”.
And anyone who’s suffered through a sleepless hot night will know how important temperature is to our sleep.
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“Capsaicin is the chemical in spicy food that causes our temperature to skyrocket, so combine this with the energy your body needs to digest the remainder of the meal, and you can really struggle getting some solid sleep,” the expert ended.
Recently, my kids started teasing me about snoring. I didn’t realise I was snoring, so I headed down a Google rabbit hole.
I searched through the reasons why people snore, and soon I discovered that lifelong habits that I thought were normal were actually warning signs for obstructive sleep apnoea.
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Obstructive sleep apnoea is a condition that involves a person’s airway closing when they sleep. It might close partially or completely.
Of the nearly 30 million Americans who live with obstructive sleep apnoea, up to 80% have never been diagnosed, according to a report from the American Academy of Sleep Medicine.
How are so many people missing the signs of sleep apnoea? I asked experts to break down the symptoms and explain why they can be easily overlooked.
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Snoring is the biggest red flag ― but it’s not always consistent.
Snoring is a well-known sleep apnoea sign, but many people don’t realise they’re doing it. I missed this sign for years because I was asleep, my husband was asleep, and I wasn’t doing it consistently. Sleep apnoea can look a little different for women, and snoring isn’t always the No. 1 sign.
Snoring can also get easily overlooked by a person who lives alone. Eventually, they might move in with a significant other or share a room while traveling with friends who will point out their noisy sleep habits.
Once the person’s snoring becomes bothersome, they might decide to get checked by a specialist.
“The most common reason why people end up in my clinic is because they have what we like to call ‘unacceptable snoring,’” said Dr. Robson Capasso, chief of sleep surgery at Stanford Medicine in California.
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While most snoring tends to feel unacceptable, it’s not always caused by sleep apnoea, and it’s not always a health risk. When you breathe, air passes the tissues at the back of your throat, causing them to vibrate and make noise. This is called primary snoring, and there’s no disruption to airflow. It might be annoying to others, but it’s not dangerous.
With sleep apnoea, those tissues can relax and collapse, causing your airway to become fully or partially blocked. Snoring is the sound of air working its way through the tissues. It can also cause pauses in breathing, choking or gasping, depending on the severity of the blockage.
“I would say that for almost everybody who has received complaints about their snoring, it really doesn’t hurt to have a further evaluation and see if this is primary snoring versus sleep apnoea,” Capasso said.
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A sleep assessment will show if you are having drops in oxygen frequency, which point to sleep apnoea. It’s important to get treated since the condition can lead to health issues like heart disease, stroke, or accidents.
If you’re curious about whether you snore, Capasso recommended the SnoreLab app, which helps you track the frequency and intensity of your snoring. While it can’t diagnose sleep apnoea, it can give you a clearer picture of your habits, like whether you’re snoring for five minutes or several hours.
Maria Korneeva via Getty Images
Don’t ignore these three major indicators of sleep apnoea.
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Feeling tired during the day is also a sign (even more so if you believe you’ve had a full night’s rest).
We live in a rise-and-grind culture in which it’s easy to tie our exhaustion to a full-time job, a busy schedule or parenthood. But if you’re getting less oxygen and experiencing breathing disruptions all night long, you’re not just going to be tired. You’re going to be sleepy to the point of passing out at inappropriate times.
Ever since I started driving at age 16, I’ve had trouble staying awake on trips that take more than 20 minutes. It’s grown worse as I’ve aged, and I always thought this “highway hypnosis” was normal. Now, I’ve learned that it’s a warning sign.
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In addition to getting sleepy while driving, sleep apnoea sufferers might drift off in situations in which a well-rested person wouldn’t be struggling to stay awake.
“You’re allowed to be bored, but dozing off or falling asleep whenever you are sedentary — watching TV, reading a book, sitting in the theatre —those are not normal things,” said Dr. R. Nisha Aurora, a sleep clinician and AASM spokesperson.
Of course, the key here is determining whether you’re still falling asleep in these situations despite getting consistent, lengthy sleep most nights.
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“If you’re having a good number of hours of sleep … and the sleep schedule is regular … you shouldn’t be sleepy; if you are, you should see a sleep specialist,” Capasso said.
Before ordering a sleep test, physicians will typically evaluate environmental factors: Does the person work overnight shifts? Do they drink or smoke? Do they stay up late bingeing movies?
The first step is fixing those issues. Once good sleep hygiene is established, if problems persist, a provider might recommend a sleep test.
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Sleep apnoea can also be confused with normal signs of aging or stress.
Beyond snoring and sleepiness, I was surprised to discover that insomnia, nighttime awakening, and certain daytime problems like mood changes and cognitive issues can be connected to sleep apnoea. These are symptoms that can easily be attributed to other conditions like aging, stress, menopause, or, in my case, the challenges of being a parent.
Aurora said that there’s a “glaring issue with underdiagnosis in women who really tend to present differently, especially once they’re post-menopausal.”
Many post-menopausal women experience insomnia, and physicians might focus on that rather than testing for sleep apnoea. Other markers of sleep apnoea in women can include headaches, depression, brain fog, and frequently waking up to urinate.
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Research shows that the prevalence of obstructive sleep apnoea increases as women experience menopause, which can disguise the symptoms and make diagnosis even more difficult.
“We can’t just say, ‘this is normal, this is part of aging,’” said Aurora. “It could be just menopause alone … but they still should get checked out.”
So… what should you do?
Report any symptoms to your doctor, even if they seem “normal.” As awareness has increased, physicians are more likely to proactively evaluate a person with symptoms that look a little different.
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“You’re always going to find that one paper that’s going to link sleep apnoea to almost everything… golf scores, hair loss, skin health,” Capasso said.
While sleep apnoea can affect various aspects of a person’s life, it’s important to avoid obsessing over sleep perfection or less-established symptoms.
“You hear sleep apnoea is underdiagnosed, and therefore, untreated,” Capasso said.
“My feelings are actually kind of mixed about this, as I believe there is a significant dichotomy. On one side, there is a community that’s super tuned to their health, longevity-oriented, wellness-oriented … I jokingly say there is almost hyperawareness of sleep apnoea, as sleep tests are positive in a significant percentage of adults.
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“On the other hand, perimenopausal women, underserved communities, people with cardiovascular diseases – this is the population where we should work harder to increase awareness. This is a population that needs to be more proactively investigated.”
Scientists already think that regular poor sleep, especially in midlife, might increase your odds of developing dementia (less than five hours a night has been associated with double the risk).
The researchers involved in the study found that those with “chronic insomnia” could face an increased dementia risk.
How much bad sleep does it take to raise my dementia risk?
In this paper, “chronic insomnia” was defined as having trouble sleeping for at least three nights a week for at least three months.
Some 2,750 participants with an average age of 70 were tracked for 5.6 years. They were all dementia-free at the start of the study, and 16% had chronic insomnia.
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After conducting memory and thinking tests as well as brain scans, the scientists found that those who reported insomniac sleep patterns had more amyloid plaque formation, which is linked to dementia development.
Of those who self-reported chronic insomnia at the start of the study, 14% went on to develop insomnia, compared to 10% among those who didn’t have sleep issues.
People with insomnia were 40% more likely to develop mild cognitive impairment or dementia than those without insomnia.
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Speaking to MedicalNewsToday, the study’s lead author, Dr Diego Z Carvalho, said: “In our models, the impact of insomnia on the risk of mild cognitive impairment/dementia was higher than having two cardiometabolic conditions like hypertension and diabetes, or being 3.5 years older than your actual age, which are known risk factors.”
Why might insomnia affect dementia risk?
We still can’t say for sure, but Dr Carvalho suggested this research has given him some ideas.
“We found that insomnia with reduced sleep was not only associated with Alzheimer’s disease biomarkers like amyloid, but also with poorer cerebrovascular health with greater evidence for small vessel disease as shown by white matter hyperintensities,” he said.
This matters because both the buildup of amyloid plaque proteins and poorer heart and vessel health are independently linked to increased dementia risk.
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The lead researcher also recommended that more doctors include sleep tests in their regular screenings, especially with older patients.