The collection of microbes living in your digestive tract is known as the gut microbiome. While everyone has one, some people’s microbiomes produce large amounts of methane, whereas others produce very little.

Microbes and the Energy Hidden in Fiber

The study found that people whose microbiomes generate more methane tend to extract more energy from high-fiber foods. This may help explain why the same meal can provide different calorie counts for different individuals once it reaches the colon.

Researchers emphasized that high-fiber foods remain beneficial. People generally absorb more calories from a typical Western diet high in processed foods, regardless of methane levels. Even so, calorie absorption on a fiber-rich diet varies depending on how much methane a person’s gut produces.

These findings suggest that gut methane could become a key factor in personalized nutrition — a future where diets are tailored to the unique microbial activity in each person’s digestive system

“That difference has important implications for diet interventions. It shows people on the same diet can respond differently. Part of that is due to the composition of their gut microbiome,” says Blake Dirks, lead author of the study and graduate researcher at the Biodesign Center for Health Through Microbiomes. Dirks is also a PhD student in ASU’s School of Life Sciences.

Meet the Methane Makers

Published in The ISME Journal, the study identifies the key players: methane-producing microbes known as methanogens. These microorganisms appear to be linked with more efficient digestion and higher energy absorption.

A major job of the microbiome is breaking down food that the body cannot digest on its own. Microbes ferment fiber into short-chain fatty acids (SCFAs), which provide a valuable energy source. During this process, hydrogen gas is released. Too much hydrogen can slow fermentation, but other microbes prevent this by consuming hydrogen — keeping the digestive chemistry in balance.

Methanogens are the hydrogen consumers. As they feed on hydrogen, they release methane as a byproduct. They are the only microbes in the human gut that produce this gas.

“The human body itself doesn’t make methane, only the microbes do. So we suggested it can be a biomarker that signals efficient microbial production of short-chain fatty acids,” says Rosy Krajmalnik-Brown, corresponding author of the study and director of the Biodesign Center for Health Through Microbiomes.

How Microbes May Shape Metabolism

The ASU researchers found that the interactions between these microbes may directly affect metabolism. Participants who produced more methane also had higher levels of short-chain fatty acids, indicating that more energy was being created and absorbed in the gut.

To test these effects, each participant followed two different diets. One included highly processed, low-fiber foods, while the other emphasized whole foods and fiber. Both diets contained equal proportions of carbohydrates, proteins, and fats.

The research was conducted in collaboration with the AdventHealth Translational Research Institute, which provided access to a specialized facility. Each participant spent six days in a sealed, hotel-like room called a whole-room calorimeter. This environment allowed researchers to precisely measure metabolism and methane output.

Unlike traditional methods that rely on a single breath test, this setup continuously captured methane released through both breath and other emissions (ahem), providing a more accurate view of microbial activity.

“This work highlights the importance of the collaboration between clinical-translational scientists and microbial ecologists. The combination of precise measures of energy balance through whole-room calorimetry with ASU’s microbial ecology expertise made key innovations possible,” says Karen D. Corbin, a co-author and associate investigator at the institute.

Tracking Energy and Microbial Activity

Data collected from blood and stool samples revealed how much energy participants absorbed from their food and how active their gut microbes were. Researchers then compared people with high methane production to those with lower levels.

Almost all participants absorbed fewer calories while eating the high-fiber diet compared to the processed-food diet. However, those with higher methane production absorbed more calories from the fiber-rich foods than those with less methane in their systems.

A Step Toward Personalized Health

The findings lay important groundwork for future studies and medical applications.

This research creates a foundation for future studies and medical treatments.

“The participants in our study were relatively healthy. One thing that I think would be worthy to look at is how other populations respond to these types of diets — people with obesity, diabetes or other kinds of health states,” Dirks says.

Although the study did not aim to induce weight loss, some participants did lose a small amount while following the high-fiber diet. Future research may explore how methanogens influence weight-loss efforts or specialized nutrition programs.

“You can see how important it is that the microbiome is personalized,” Krajmalnik-Brown says. “Specifically, the diet that we designed so carefully to enhance the microbiome for this experiment had different effects on each person, in part because some people’s microbiomes produced more methane than others.”

Other members of the ASU research team include Professor Bruce Rittmann and graduate researcher Taylor Davis.

This project was funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.

The work was led by Dr. Liv Tybjærg Nordestgaard during her time at the University of Bristol and at the Department of Clinical Biochemistry at Copenhagen University Hospital — Herlev and Gentofte. The findings were published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

Genetic Clues and Cholesterol-Lowering Effects

Some individuals are born with genetic variants that affect the same proteins targeted by cholesterol-lowering medications such as statins and ezetimibe. To explore whether these drugs might influence dementia risk, the team used a technique called Mendelian Randomization. This method allows scientists to study how specific genetic variants mimic the effects of a treatment while minimizing the influence of outside factors like weight, diet, or lifestyle.

By comparing people with and without these cholesterol-lowering genetic variants, the researchers observed a clear difference in dementia risk. A small decrease in cholesterol levels (about one millimole per liter) was associated with up to an 80% reduction in dementia risk for certain drug-related genetic targets.

Lower Cholesterol, Lower Dementia Risk

“What our study indicates is that if you have these variants that lower your cholesterol, it looks like you have a significantly lower risk of developing dementia,” said Dr. Nordestgaard, who now works in the Department of Clinical Biochemistry at Copenhagen University Hospital — Bispebjerg and Frederiksberg hospital.

The results suggest that keeping cholesterol levels low — whether through genetics or medical treatment — may protect against dementia. However, the research does not yet confirm that cholesterol-lowering drugs themselves directly prevent the disease.

Why Studying Dementia Is So Challenging

Because dementia often develops late in life, studying its causes requires tracking participants for decades. This makes it difficult to establish cause and effect in traditional clinical trials.

It also remains unclear why high cholesterol raises dementia risk. One explanation, according to Dr. Nordestgaard, is that high cholesterol contributes to atherosclerosis — the buildup of fatty deposits in blood vessels.

How Cholesterol May Harm the Brain

“Atherosclerosis is a result of the accumulation of cholesterol in your blood vessels,” Dr. Nordestgaard said. “It can be in both the body and the brain and increases the risk of forming small blood clots — one of the causes of dementia.

“It would be a really good next step to carry out randomised clinical trials over 10 or 30 years, for example, where you give the participants cholesterol-lowering medication and then look at the risk of developing dementia,” Dr. Nordestgaard added.

Global Collaboration and Funding

The study used data from the UK Biobank, the Copenhagen General Population Study, the Copenhagen City Heart Study, the FinnGen study, and the Global Lipids Genetics Consortium.

Funding was provided by the Medical Research Council, Independent Research Fund Denmark, and Research Council at the Capital Region of Denmark (LTN).

Voris, a PhD candidate in the Department of Earth, Energy, and Environment, explains that this newly identified Tyrannosaur lived about 86 million years ago. It was a medium-sized, fast-moving predator that evolved after the extinction of other large carnivorous dinosaurs.

A Glimpse Into Tyrannosaur Evolution

According to Voris, “This new species provides us the window into the ascent stage of Tyrannosaur evolution; right when they’re transitioning from small predators to their apex predator form.” Khankhuuluu is regarded as the nearest known ancestor of the colossal Tyrannosaurs popularized by films like Jurassic Park.

The name Khankhuuluu comes from Mongolian and translates to “prince of dragons” or “the dragon prince.” The name reflects its position in the Tyrannosaur family tree — standing as the “prince” before the “king,” Tyrannosaurus rex. At roughly 750 kilograms (about the size of a horse), it was two to three times smaller than its enormous descendants but shared many of their defining traits.

Physical Traits and Hunting Style

Khankhuuluu displayed small horn-like structures on its head, features that later became more pronounced in later Tyrannosaur species such as Albertosaurus and Gorgosaurus, likely used for mating displays or intimidation. Its long, shallow skull indicates it lacked the bone-crushing bite strength of T. rex. Instead, scientists describe Khankhuuluu as a mesopredator, similar to modern coyotes, relying on speed and agility to hunt.

Fossils From Mongolia Tell a New Story

The fossils were unearthed from the Bayanshiree Formation in southeastern Mongolia and were first studied in the 1970s by paleontologist Altangerel Perle, who initially compared them to a similar species known as Alectrosaurus from China. When Voris examined the fossils in 2023 at the Institute of Paleontology in Mongolia, he noticed subtle but key differences that distinguished them from Alectrosaurus.

The Journey of Tyrannosaurs Between Continents

Dr. Zelenitsky explains that Khankhuuluu or a closely related species likely migrated from Asia to North America around 85 million years ago.”Our study provides solid evidence that large Tyrannosaurs first evolved in North America as a result of this immigration event,” she says.

The research suggests these migrations between Asia and North America were rarer and more limited than previously believed. Khankhuuluu appears to be the last known Asian ancestor of the Tyrannosaurs before their diversification in North America.

From the “Dragon Prince” to the Tyrant King

Scientists believe that Khankhuuluu, or one of its relatives, crossed a land bridge into North America, where it evolved into the formidable apex predator Tyrannosaurs. Fossil evidence shows that Tyrannosaurs thrived in North America for several million years before returning to Asia, where their lineage split into two branches: one evolved into massive predators like T. rex, while the other produced more slender, long-snouted types nicknamed “Pinocchio rexes.”

What Comes Next in the Research

Looking ahead, the team plans to study earlier and less-understood ancestors of these apex predators to fill in the remaining gaps of the Tyrannosaur evolutionary story.

It might sound like science fiction, yet this breakthrough is real. A team of physicists at the University of Konstanz, led by Davide Bossini, has developed an experimental technique that makes it possible. By using laser pulses to coherently excite pairs of magnons (quanta of spin waves), the researchers achieved remarkable effects that could influence both information technology and quantum research. Their findings were published in Science Advances.

Technology based on magnons

Before diving deeper, it helps to understand what magnons are and why they matter. The modern world generates enormous amounts of data through artificial intelligence and the “Internet of Things.” Our current information systems are already straining under the pressure, and a data bottleneck threatens to slow technological progress.

One proposed solution is to use electron spins — or even better, waves of many spins moving together — to carry information. These collective spin oscillations are called magnons. They behave like waves and can be manipulated by lasers, potentially allowing data transmission and storage at terahertz frequencies.

So far, however, scientists have only been able to excite magnons at their lowest frequencies using light, which limits their potential. To harness magnons for future technologies, researchers must be able to tune their frequency, amplitude, and lifetime. The team at Konstanz has now found a way to do exactly that. By directly exciting pairs of magnons — the highest-frequency magnetic resonances in a material — they discovered a powerful new form of control.

A huge surprise

“The result was a huge surprise for us. No theory has ever predicted it,” says Davide Bossini. Not only does the process work — it also has spectacular effects. By driving high-frequency magnon pairs via laser pulses, the physicists succeeded in changing the frequencies and amplitudes of other magnons — and thus the magnetic properties of the material — in a non-thermal way. “Every solid has its own set of frequencies: electronic transitions, lattice vibrations, magnetic excitations. Every material resonates in its own way,” explains Bossini. It is precisely this set of frequencies that can be influenced through the new process. “It changes the nature of the material, the ‘magnetic DNA of the material’, so to speak, its ‘fingerprint’. It has practically become a different material with new properties for the time being,” says Bossini.

“The effects are not caused by laser excitation. The cause is light, not temperature,” confirms Bossini: “We can change the frequencies and properties of the material in a non-thermal way.” The advantages are obvious: The method could be used for future data storage and for fast data transmission at terahertz rates without the systems being slowed down by the pileup of heat.

No spectacular high-tech materials or rare earths are required as the basis for the process, but rather naturally grown crystals — namely the iron ore haematite. “Haematite is widespread. Centuries ago, it was already used for compasses in seafaring,” explains Bossini. It is perfectly possible that haematite will now also be used for quantum research in the future. The results of the Konstanz team suggest that, using the new method, researchers will be able to produce light-induced Bose-Einstein condensates of high-energy magnons at room temperature. This would pave the way to researching quantum effects without the need for extensive cooling. Sounds like magic, but it is just technology and cutting-edge research.

The project was carried out in the context of the Collaborative Research Centre SFB 1432 “Fluctuations and Nonlinearities in Classical and Quantum Matter beyond Equilibrium.”