One of the most common reasons for bypassing the COVID vaccine is concern about side effects like tiredness, muscle and joint pain, chills, headache, fever, nausea and feeling generally unwell. But a new study, led by UC San Francisco, has found that the symptoms indicate a robust immune response that is likely to lessen the chances of infection.

The study, which appears online June 10 in Annals of Internal Medicine, is based on symptom reports and antibody responses from 363 people, who had the Pfizer-BioNTech or Moderna mRNA vaccines when they were first introduced.

After the second dose of the vaccine, the researchers found that those with seven or more symptoms had nearly double the antibody levels of those who did not have symptoms. The participants were mainly in their forties to sixties and had not had the virus.

About 40% of the people in the study also wore a device to monitor their temperature, breathing and heart rate. The researchers found that those whose skin temperature increased by 1 degree Celsius after the second dose had three times the antibody levels six months later, compared to those whose temperature did not increase.

An absence of side effects does not mean the vaccine is not working

“Generally, we found that the higher the number of side effects, the higher the level of antibodies,” said first author Ethan Dutcher, MD, PhD, a postdoctoral researcher in the UCSF Department of Psychiatry and Behavioral Sciences, and the Weill Institute for Neurosciences. “But this wasn’t a hard rule: some people without side effects had better antibodies than some people with side effects.”

As the virus has evolved and fatality rates have fallen, many people are underestimating its impact. “The toll of COVID is still high for some — sickness, lost work, lasting fatigue and the dreaded long COVID,” said co-senior author Elissa Epel, PhD, a vice chair in the UCSF Department of Psychiatry and Behavioral Sciences. “While the symptoms from vaccination can be very unpleasant, it’s important to remember that they don’t come close to the disease’s potential complications,” she said.

“With COVID-19 vaccines likely here to stay, identifying what predicts a strong antibody response will remain important,” said co-senior author Aric Prather, PhD, professor in the UCSF Department of Psychiatry and Behavioral Sciences.

The latest recommendations from the Centers for Disease Control and Prevention are that everyone 6 months and older should receive the updated vaccine, and those 65 and older should receive an additional dose.

Co-Authors: Ashley Mason, PhD, and Frederick Hecht, MD, of UCSF; James E. Robinson, MD, of Tulane University; and Stacy Drury, MD, PhD, of Tulane University and Boston Children’s Hospital.

Funding: National Institutes of Health (R24AG048024, 5U24AG066528 and U54CA260581).

Disclosures: Epel is on the scientific advisory boards of Meru Health and Oura Health. Mason has receiving consultancy fees from Oura Health. Prather is an advisor to NeuroGeneces and L-New Co.

Thanks to the efforts of a citizen science project called Backyard Worlds: Planet 9 and a team of astronomers from around the country, a rare hypervelocity L subdwarf star has been found racing through the Milky Way. More remarkably, this star may be on a trajectory that causes it to leave the Milky Way altogether. The research, led by University of California San Diego Professor of Astronomy and Astrophysics Adam Burgasser, was presented today at a press conference during the 244^th national meeting of the American Astronomical Society (AAS) in Madison, Wisconsin.

The star, charmingly named CWISE J124909+362116.0 (“J1249+36”), was first noticed by some of the over 80,000 citizen science volunteers participating in the Backyard Worlds: Planet 9 project, who comb through enormous reams of data collected over the past 14 years by NASA’s Wide-field Infrared Survey Explorer (WISE) mission. This project capitalizes on the keen ability of humans, who are evolutionarily programmed to look for patterns and spot anomalies in a way that is unmatched by computer technology. Volunteers tag moving objects in data files and when enough volunteers tag the same object, astronomers investigate.

J1249+36 immediately stood out because of the speed at which it is moving across the sky, initially estimated at about 600 kilometers per second (1.3 million miles per hour). At this speed, the star is fast enough to escape the gravity of the Milky Way, making it a potential “hypervelocity” star.

To better understand the nature of this object, Burgasser turned to the W.M. Keck Observatory in Maunakea, Hawaii to measure its infrared spectrum. These data revealed that the object was a rare L subdwarf — a class of stars with very low mass and temperature. Subdwarfs represent the oldest stars in the Milky Way.

The insight into J1249+36’s composition was made possible by a new set of atmosphere models created by UC San Diego alumnus Roman Gerasimov, who worked with UC LEADS scholar Efrain Alvarado III to generate models specifically tuned to study L subdwarfs. “It was exciting to see that our models were able to accurately match the observed spectrum,” said Alvarado, who is presenting his modeling work at the AAS meeting.

The spectral data, along with imaging data from several ground-based telescopes, allowed the team to accurately measure J1249+36’s position and velocity in space, and thereby predict its orbit through the Milky Way. “This is where the source became very interesting, as its speed and trajectory showed that it was moving fast enough to potentially escape the Milky Way,” stated Burgasser.

What gave this star a kick?

Researchers focused on two possible scenarios to explain J1249+36’s unusual trajectory. In the first scenario, J1249+36 was originally the low-mass companion of a white dwarf. White dwarfs are the remnant cores of stars that have depleted their nuclear fuel and died out. When a stellar companion is in a very close orbit with a white dwarf, it can transfer mass, resulting in periodic outbursts called novae. If the white dwarf collects too much mass, it can collapse and explode as a supernova.

“In this kind of supernova, the white dwarf is completely destroyed, so its companion is released and flies off at whatever orbital speed it was originally moving, plus a little bit of a kick from the supernova explosion as well,” said Burgasser. “Our calculations show this scenario works. However, the white dwarf isn’t there anymore and the remnants of the explosion, which likely happened several million years ago, have already dissipated, so we don’t have definitive proof that this is its origin.”

In the second scenario, J1249+36 was originally a member of a globular cluster, a tightly bound cluster of stars, immediately recognizable by its distinct spherical shape. The centers of these clusters are predicted to contain black holes of a wide range of masses. These black holes can also form binaries, and such systems turn out to be great catapults for any stars that happen to wander too close to them.

“When a star encounters a black hole binary, the complex dynamics of this three-body interaction can toss that star right out of the globular cluster,” explained Kyle Kremer, an incoming Assistant Professor in UC San Diego’s Department of Astronomy and Astrophysics. Kremer ran a series of simulations and found that on rare occasions these kinds of interactions can kick a low-mass subdwarf out of a globular cluster and on a trajectory similar to that observed for J1249+36.

“It demonstrates a proof of concept,” said Kremer, “but we don’t actually know what globular cluster this star is from.” Tracing J1249+36 back in time puts it in a very crowded part of the sky that may hide undiscovered clusters.

To determine whether either of these scenarios, or some other mechanism, can explain J1249+36’s trajectory, Burgasser said the team hopes to look more closely at its elemental composition. For example, when a white dwarf explodes, it creates heavy elements that could have “polluted” the atmosphere of J1249+36 as it was escaping. The stars in globular clusters and satellite galaxies of the Milky Way also have distinct abundance patterns that may reveal the origin of J1249+36.

“We’re essentially looking for a chemical fingerprint that would pinpoint what system this star is from,” said Gerasimov, whose modeling work has enabled him to measure the element abundances of cool stars in several globular clusters, work he is also presenting at the AAS meeting.

Whether J1249+36’s speedy journey was because of a supernova, a chance encounter with a black hole binary, or some other scenario, its discovery provides a new opportunity for astronomers to learn more about the history and dynamics of the Milky Way.

“Webb is a supernova discovery machine,” said Christa DeCoursey, a third-year graduate student at the Steward Observatory and the University of Arizona in Tucson. “The sheer number of detections plus the great distances to these supernovae are the two most exciting outcomes from our survey.”

DeCoursey presented these findings at the 244th meeting of the American Astronomical Society in Madison, Wisconsin.

‘A Supernova Discovery Machine’

To make these discoveries, the team analyzed imaging data obtained as part of the JWST Advanced Deep Extragalactic Survey (JADES) program. Webb is ideal for finding extremely distant supernovae because their light is stretched into longer wavelengths — a phenomenon known as cosmological redshift.

Prior to Webb’s launch, only a handful of supernovae had been found above a redshift of 2, which corresponds to when the universe was only 3.3 billion years old — just 25% of its current age. The JADES sample contains many supernovae that exploded even further in the past, when the universe was less than 2 billion years old.

Previously, researchers used NASA’s Hubble Space Telescope to view supernovae from when the universe was in the “young adult” stage. With JADES, scientists are seeing supernovae when the universe was in its “teens” or “pre-teens.” In the future, they hope to look back to the “toddler” or “infant” phase of the universe.

To discover the supernovae, the team compared multiple images taken up to one year apart and looked for sources that disappeared or appeared in those images. These objects that vary in observed brightness over time are called transients, and supernovae are a type of transient. In all, the JADES Transient Survey Sample team uncovered about 80 supernovae in a patch of sky only about the thickness of a grain of rice held at arm’s length.

“This is really our first sample of what the high-redshift universe looks like for transient science,” said teammate Justin Pierel, a NASA Einstein Fellow at the Space Telescope Science Institute (STScI) in Baltimore, Maryland. “We are trying to identify whether distant supernovae are fundamentally different from or very much like what we see in the nearby universe.”

Pierel and other STScI researchers provided expert analysis to determine which transients were actually supernovae and which were not, because often they looked very similar.

The team identified a number of high-redshift supernovae, including the farthest one ever spectroscopically confirmed, at a redshift of 3.6. Its progenitor star exploded when the universe was only 1.8 billion years old. It is a so-called core-collapse supernova, an explosion of a massive star.

Uncovering Distant Type Ia Supernovae

Of particular interest to astrophysicists are Type Ia supernovae. These exploding stars are so predictably bright that they are used to measure far-off cosmic distances and help scientists to calculate the universe’s expansion rate. The team identified at least one Type Ia supernova at a redshift of 2.9. The light from this explosion began traveling to us 11.5 billion years ago when the universe was just 2.3 billion years old. The previous distance record for a spectroscopically confirmed Type Ia supernova was a redshift of 1.95, when the universe was 3.4 billion years old.

Scientists are eager to analyze Type Ia supernovae at high redshifts to see if they all have the same intrinsic brightness, regardless of distance. This is critically important, because if their brightness varies with redshift, they would not be reliable markers for measuring the expansion rate of the universe.

Pierel analyzed this Type Ia supernova found at redshift 2.9 to determine if its intrinsic brightness was different than expected. While this is just the first such object, the results indicate no evidence that Type Ia brightness changes with redshift. More data is needed, but for now, Type Ia supernova-based theories about the universe’s expansion rate and its ultimate fate remain intact. Pierel also presented his findings at the 244th meeting of the American Astronomical Society.

Looking Toward the Future

The early universe was a very different place with extreme environments. Scientists expect to see ancient supernovae that come from stars that contain far fewer heavy chemical elements than stars like our Sun. Comparing these supernovae with those in the local universe will help astrophysicists understand star formation and supernova explosion mechanisms at these early times.

“We’re essentially opening a new window on the transient universe,” said STScI Fellow Matthew Siebert, who is leading the spectroscopic analysis of the JADES supernovae. “Historically, whenever we’ve done that, we’ve found extremely exciting things — things that we didn’t expect.”

“Because Webb is so sensitive, it’s finding supernovae and other transients almost everywhere it’s pointed,” said JADES team member Eiichi Egami, a research professor at the University of Arizona in Tucson. “This is the first significant step toward more extensive surveys of supernovae with Webb.”

The James Webb Space Telescope is the world’s premier space science observatory. Webb is solving mysteries in our solar system, looking beyond to distant worlds around other stars, and probing the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).